DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and TPO

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	XP_024308853.1	Gene:	TPO / 7173	HGNCID:	12015	Length:	947	Species:	Homo sapiens

Alignment Length:	787	Identity:	243/787 - (30%)
Similarity:	365/787 - (46%)	Gaps:	136/787 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SFF-FVVNGSDSELAPNRPLPDEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEEG-LQPN 143
            :|| |:..|  .||...:  |:|......|:::       .:.|...:.|...|.:.:.| |.|.
Human    30 AFFPFISRG--KELLWGK--PEESRVSSVLEES-------KRLVDTAMYATMQRNLKKRGILSPA 83

  Fly   144 EVNTPSFRHYRSLSTNPEARK--LARRGYVENQATIDIAKRFNYTKQPGRSNIGWGPKIVLPD-- 204
            ::        .|.|..||...  :||...:...:...:.::.|...|..:.     |...|.:
Human    84 QL--------LSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQH-----PTDALSEDL 135

  Fly   205 -----------PTVLRLECDFNA---RYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAA 255
                       |.:|..:|....   :||..||.|||:.||| :|||.....|.:.|.|.||.:.
Human   136 LSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPR-WGASNTALARWLPPVYEDGFSQ 199

  Fly   256 PRVSHHG------RLPPARQVSLKIHRSSYET---DSNFTVMLAVFGQFMDHDITATSLTTSQE- 310
            ||..:.|      .|||.|:|:..:.:.|.|.   |..::.:|..:||::||||..|..:||:.
Human   200 PRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAA 264

  Fly   311 -GESIDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAPA-PTGRFG----------P 363
             |...||  ..|.|....|:|:. ||::. ......:|:.|.||:.| .||..|          |
Human   265 FGGGADC--QMTCENQNPCFPIQ-LPEEA-RPAAGTACLPFYRSSAACGTGDQGALFGNLSTANP 325

  Fly   364 RMQLNQATAFIDASVVYGNLEQRQNQLRSFIN--GSLRMF--VTDDGRQLLPISSNPADGCNRVQ 424
            |.|:|..|:|:|||.|||:....:.|||::.:  |.||:.  :.|.||..||.....|......:
Human   326 RQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPE 390

  Fly   425 MTRLGKY---CFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGA 486
            ....|:.   ||.:||.||:|...||::|.||.|.||.||..|:..|.||..:.:||||||::||
Human   391 PGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGA 455

  Fly   487 QMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTL---- 547
            ....||..:::|.:||....:        ..:...:.||...:|:::|.|:.|||||.|..
Human   456 LHQIITLRDYIPRILGPEAFQ--------QYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPL 512

  Fly   548 -------------LPGLFNISRDNSTPEAIELHKMLFNPFSLWAEHGIDHALMTAANTPV-MQV- 597
                         ||||:             ||:..|:|::|....|:|..:......|. :||
Human   513 VRRLDASFQEHPDLPGLW-------------LHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQ 564

  Fly   598 DRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQA 662
            |:..:.|:|::||..:....     |||.|:|:|||||||:|.|..:|..|.||.::|..::|.|
Human   565 DQLMNEELTERLFVLSNSST-----LDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTA 624

  Fly   663 I-DNATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMG 726
            | ..:..|.|..:|:.|.::||:.|.|:|..|..|..|||.:|::..|...|:.||..|:|..
Human   625 IASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENS-- 687

  Fly   727 PQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPH--VDCQDLEGFHFNFEPWS 789
             ..||.||..|:.|.||:.:||.|: |:|||   .|...:.|..|.  ..|..:.|  .|.|.|.
Human   688 -HVFTDAQRRELEKHSLSRVICDNT-GLTRV---PMDAFQVGKFPEDFESCDSITG--MNLEAWR 745

  Fly   790 EKQQPQD 796
            | ..|||
Human   746 E-TFPQD 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	200/585 (34%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	141/412 (34%)
TPO	XP_024308853.1	thyroid_peroxidase	179..746	CDD:188657	201/605 (33%)
TPO	XP_024308853.1	CCP	754..807	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2660
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870