DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cd and DUOX2

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001350640.1	Gene:	DUOX2 / 50506	HGNCID:	13273	Length:	1548	Species:	Homo sapiens

Alignment Length:	570	Identity:	167/570 - (29%)
Similarity:	245/570 - (42%)	Gaps:	102/570 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 RRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAPRVSHHGRLPPARQVSLKIHRSSYETDS 283
            :|..|..||.:| ...||.....:|.|..:||||:.  :.....:||..|::|....|......|
Human    36 QRYDGWFNNLRH-HERGAVGCRLQRRVPANYADGVY--QALEEPQLPNPRRLSNAATRGIAGLPS 97

  Fly   284 --NFTVMLAVFGQFMDHDITATSLTTSQEGESIDCCVAATREQHPECYPVDIL-----PDDPYY- 340
              |.||:...||..:..|:.:.                    :.|.| |.:.|     |.||.:
Human    98 LHNRTVLGVFFGYHVLSDVVSV--------------------ETPGC-PAEFLNIRIPPGDPVFD 141

  Fly   341 -KQYNISCMNFVRSAPAP-TGR--FGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLR-- 399
             .|.....:.|.||...| |||  ..||...||.|.::|.|.:||:.....:.||||..|.|.
Human   142 PDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASG 206

  Fly   400 ---MFVTDDGRQLLP-ISSNPADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYL 460
               .|..|....||. .:.:||.|.|..:    |.|.|  |.:|.|....|.::.|||.|:||..
Human   207 PDPAFPRDSQNPLLMWAAPDPATGQNGPR----GLYAF--GAERGNREPFLQALGLLWFRYHNLW 265

  Fly   461 ARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTYD 525
            |::|..|:|.||||.|:|.|||.:.|...:|...|:||..|.|.:.|..|             |.
Human   266 AQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTG-------------YR 317

  Fly   526 PEVDPSIANCFAAAAFRFAHTLL-PGLFNISRDNSTPEAIELHKMLFNPFSLWAEHGIDHALMTA 589
            |.:||||:..|..|:.:|..|:: ||::  .|:.|    ....|:|...|.      ...||...
Human   318 PFLDPSISPEFVVASEQFFSTMVPPGVY--MRNAS----CHFRKVLNKGFQ------SSQALRVC 370

  Fly   590 ANTPVMQVDRFFSLEVTQKLFEGTA------EDRVPLCGL-------------DLVSLNIQRGRD 635
            .|..:.:.....|.:...:|..|.|      ||.:.:..|             |.|:.:||||||
Human   371 NNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRD 435

  Fly   636 HGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATLDSIRQIYESPQD---VDVYTGALSEPPLDGAI 697
            .|:|||........|.....|.:::..:|...|::...:|.  ||   :::..|.|.|...|.
Human   436 MGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYN--QDLSQLELLLGGLLESHGDP-- 496

  Fly   698 FGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAII 747
             |||.|.:|.|||:||:.||.:|:|.... ..|:|.::.:|..|:|..::
Human   497 -GPLFSAIVLDQFVRLRDGDRYWFENTRN-GLFSKKEIEDIRNTTLRDVL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	167/570 (29%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	126/413 (31%)
DUOX2	NP_001350640.1	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		167/570 (29%)
		dual_peroxidase_like	38..594	CDD:188652	166/568 (29%)
		EFh_PEF	<764..858	CDD:330173
		EFh	824..885	CDD:238008
		EF-hand_7	857..929	CDD:316058
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1245
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..991
		Ferric_reduct	1088..1223	CDD:307763
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910