Protein Alignment cd and LPO

DIOPT Version :10

• Sequence 1: NP_651081.1
• Gene: cd / 42681
• FlyBaseID: FBgn0263986
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: NP_006142.1
• Gene: LPO / 4025
• HGNCID: 6678
• Length: 712
• Species: Homo sapiens
• Alignment Length: 747
• Identity: 222/747 - (29%)
• Similarity: 359/747 - (48%)
• Gaps: 101/747 - (13%)

  Fly    99 LPDEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEEGLQPNEVNTPSFRHYRSL--STNPE 161
            ||...|:...||.||    ...:|.:....|:.| .:.:..:|.|:....|....::.  |..|.
Human     7 LPALLASLILLQAAA----STTRAQTTRTSAISD-TVSQAKVQVNKAFLDSRTRLKTAMSSETPT 66

  Fly   162 ARKLA--------------RRGYVENQATIDIAKRFNYTKQPGRS--------NIGWGPKIVLPD 204
            :|:|:              |.|.|..::...:.::.:.|.....|        .:|.|    .|.
Human    67 SRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCG----APA 127

  Fly   205 PTVLRLECDFNARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAP------RVSHHGR 263
            |.|   .||..:.||..||.|||::.| ..||:.....|.:..:|.||::.|      :..:...
Human   128 PVV---RCDPCSPYRTITGDCNNRRKP-ALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFP 188

  Fly   264 LPPARQVSLKIHRSSYE---TDSNFTVMLAVFGQFMDHDI---TATSLTTSQ--EGESIDCCVAA 320
            ||.||:||.||.....|   .|.|.:::...:||.:|||:   ..|.|.:|:  :.:..:.|:
Human   189 LPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCI-- 251

  Fly   321 TREQHPECYPVDILPDDPYYKQYNISCMNFVRS---APAPTGRFGPRMQLNQATAFIDASVVYGN 382
               |...|:|:...|:||...... .||.|.|:   .|.|..:...|.|:|..|:|:|||.||.:
Human   252 ---QGDNCFPIMFPPNDPKAGTQG-KCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSS 312

  Fly   383 LEQRQNQLRSFING----SLRMFVTDDGRQLLPISSNPADGCNRVQMT-RLGKYCFESGDDRANE 442
            .....::||:..:.    ::...|:|.|...||..|.....|..:..| |:.  ||.:||.||:|
Human   313 EPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVP--CFLAGDSRASE 375

  Fly   443 NLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISE 507
            ::||.:.|.|:.|.||.|||:|:..||.|:.|:|||||||||||.:..||:.::||:|||.::.
Human   376 HILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQ- 439

  Fly   508 AKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLLP-GLFNISRD----NSTPEAIELH 567
             |.:.|.:       .|...|||.|:|.| ..||||.|..:| .:|.:..:    ...|| :.||
Human   440 -KWIPPYQ-------GYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENYQPWGPEPE-LPLH 494

  Fly   568 KMLFNPFSLWAEHGIDHAL--MTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNI 630
            .:.||.:.:..:.|||..:  :.|..:.:|:.::..:.|:..|||:.|..    :.|.||.::|.
Human   495 TLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHR----IHGFDLAAINT 555

  Fly   631 QRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATL-DSIRQIYESPQDVDVYTGALSEPPLD 694
            ||.||||.|.|..:|..|.|....|.||::..:.:..| ..:..:|.:|.::|::.||::||.::
Human   556 QRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVE 620

  Fly   695 GAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVRE 759
            ....||||:|::..||.:::.||..|:|   .|..||..|...:.|.|.:.::|.|    ||:.:
Human   621 RGRVGPLLACLLGKQFQQIRDGDRFWWE---NPGVFTNEQKDSLQKMSFSRLVCDN----TRITK 678

  Fly   760 HVMQRLRDGGNPH--VDCQDLEGFHFNFEPWS 789
            ...........|:  |||..::  ..:..||:
Human   679 VPRDPFWANSYPYDFVDCSAID--KLDLSPWA 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..762	CDD:460804	187/573 (33%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	143/434 (33%)