DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and LPO

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_006142.1	Gene:	LPO / 4025	HGNCID:	6678	Length:	712	Species:	Homo sapiens

Alignment Length:	747	Identity:	222/747 - (29%)
Similarity:	359/747 - (48%)	Gaps:	101/747 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LPDEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEEGLQPNEVNTPSFRHYRSL--STNPE 161
            ||...|:...||.||    ...:|.:....|:.| .:.:..:|.|:....|....::.  |..|.
Human     7 LPALLASLILLQAAA----STTRAQTTRTSAISD-TVSQAKVQVNKAFLDSRTRLKTAMSSETPT 66

  Fly   162 ARKLA--------------RRGYVENQATIDIAKRFNYTKQPGRS--------NIGWGPKIVLPD 204
            :|:|:              |.|.|..::...:.::.:.|.....|        .:|.|    .|.
Human    67 SRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCG----APA 127

  Fly   205 PTVLRLECDFNARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAP------RVSHHGR 263
            |.|   .||..:.||..||.|||::.| ..||:.....|.:..:|.||::.|      :..:...
Human   128 PVV---RCDPCSPYRTITGDCNNRRKP-ALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFP 188

  Fly   264 LPPARQVSLKIHRSSYE---TDSNFTVMLAVFGQFMDHDI---TATSLTTSQ--EGESIDCCVAA 320
            ||.||:||.||.....|   .|.|.:::...:||.:|||:   ..|.|.:|:  :.:..:.|:
Human   189 LPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCI-- 251

  Fly   321 TREQHPECYPVDILPDDPYYKQYNISCMNFVRS---APAPTGRFGPRMQLNQATAFIDASVVYGN 382
               |...|:|:...|:||...... .||.|.|:   .|.|..:...|.|:|..|:|:|||.||.:
Human   252 ---QGDNCFPIMFPPNDPKAGTQG-KCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSS 312

  Fly   383 LEQRQNQLRSFING----SLRMFVTDDGRQLLPISSNPADGCNRVQMT-RLGKYCFESGDDRANE 442
            .....::||:..:.    ::...|:|.|...||..|.....|..:..| |:.  ||.:||.||:|
Human   313 EPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVP--CFLAGDSRASE 375

  Fly   443 NLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISE 507
            ::||.:.|.|:.|.||.|||:|:..||.|:.|:|||||||||||.:..||:.::||:|||.::.
Human   376 HILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQ- 439

  Fly   508 AKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLLP-GLFNISRD----NSTPEAIELH 567
             |.:.|.:       .|...|||.|:|.| ..||||.|..:| .:|.:..:    ...|| :.||
Human   440 -KWIPPYQ-------GYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENYQPWGPEPE-LPLH 494

  Fly   568 KMLFNPFSLWAEHGIDHAL--MTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNI 630
            .:.||.:.:..:.|||..:  :.|..:.:|:.::..:.|:..|||:.|..    :.|.||.::|.
Human   495 TLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHR----IHGFDLAAINT 555

  Fly   631 QRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATL-DSIRQIYESPQDVDVYTGALSEPPLD 694
            ||.||||.|.|..:|..|.|....|.||::..:.:..| ..:..:|.:|.::|::.||::||.::
Human   556 QRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVE 620

  Fly   695 GAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVRE 759
            ....||||:|::..||.:::.||..|:|   .|..||..|...:.|.|.:.::|.|    ||:.:
Human   621 RGRVGPLLACLLGKQFQQIRDGDRFWWE---NPGVFTNEQKDSLQKMSFSRLVCDN----TRITK 678

  Fly   760 HVMQRLRDGGNPH--VDCQDLEGFHFNFEPWS 789
            ...........|:  |||..::  ..:..||:
Human   679 VPRDPFWANSYPYDFVDCSAID--KLDLSPWA 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	185/566 (33%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	137/398 (34%)
LPO	NP_006142.1	An_peroxidase	138..674	CDD:281139	185/566 (33%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	143/434 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820