DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and Duox

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	194/707 - (27%)
Similarity:	305/707 - (43%)	Gaps:	154/707 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 VNTPSFRHYRSLSTNPEARKLARRGYVENQATIDIAKRFNYTKQPGRSN-------IGW------ 196
            ::.||..|.|:.|.|...|                         ||:.|       :.|
  Fly     1 MSVPSAPHQRAESKNRVPR-------------------------PGQKNRKLPKLRLHWPGATYG 40

  Fly   197 GPKIVLPDPTVLRL---ECDFNARY-----RRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGI 253
            |..::|.....|.|   .| :...|     :|..|..||..|| .:|:......|...|.|:||:
  Fly    41 GALLLLLISYGLELGSVHC-YEKMYSQTEKQRYDGWYNNLAHP-DWGSVDSHLVRKAPPSYSDGV 103

  Fly   254 AAPRVSHHGRLPPARQVSLKIHRSSYETDSNF--TVMLAVFGQFMDHDITATSLTTSQEGESIDC 316
            .|...::.   |..|::|....|......|.|  |.:||.|||.:.::|    :..|:.|    |
  Fly   104 YAMAGANR---PSTRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEI----VMASESG----C 157

  Fly   317 CVAATREQHPECYPVDILPDDPYYKQYNISC-----MNFVRSA-PAPTGRF--GPRMQLNQATAF 373
            .:...|.:..:|       |:.|.::    |     :.|.|:| ...||:.  .||.|:||.||:
  Fly   158 PIEMHRIEIEKC-------DEMYDRE----CRGDKYIPFHRAAYDRDTGQSPNAPREQINQMTAW 211

  Fly   374 IDASVVYGNLEQRQNQLRSFINGSLRMFVTDDGR------QLLPISSNPADGCNR-VQMTRLGKY 431
            ||.|.:|...|...|.:|||.||:|  ....||:      ..:|:.:||.....: :...||
  Fly   212 IDGSFIYSTSEAWLNAMRSFHNGTL--LTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERL--- 271

  Fly   432 CFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEF 496
             |..||.|.|:|..:.|..:|:.|.||.||::::..:|.|.||.:||.||..:.|.:.::...|:
  Fly   272 -FLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEY 335

  Fly   497 LPVLLGKNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLL-PGLFNISRD--- 557
            ||..||.::...:|             |..::.|.|.:.|.||||||.||:: ||::.  ||
  Fly   336 LPAFLGTSLPPYEG-------------YKQDIHPGIGHIFQAAAFRFGHTMIPPGIYR--RDGQC 385

  Fly   558 --NSTP---EAIELHKMLFNPFSLWAEHGIDHALMTAANTPVMQVDRFFSLEVTQKLFEGTAEDR 617
              ..||   .|:.|....::....:|:..::..||..|:....:.|.....:|..||| |..|
  Fly   386 NFKETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLF-GPME-- 447

  Fly   618 VPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAI---DNATLDSIRQIYESP- 678
              ....||.:|||.||||:|:|.|...|....|....||.:::..:   ....||.:::.|::.
  Fly   448 --FTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKL 510

  Fly   679 QDVDVYTGALSE---PPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYK 740
            .|||||.|.:.|   .|      |...:.::.:||.||:..|..|:|.:.. ..||..::||:.|
  Fly   511 DDVDVYVGGMLESYGQP------GEFFTAVIKEQFQRLRDADRFWFENERN-GIFTPEEIAELRK 568

  Fly   741 TSLAAIICRNSDGITRVREHVMQR---LRDGGNPHVD-----------CQDLEGFHF 783
            .:|..||..::|    |:|..:|:   :...|:|...           |..|||:.:
  Fly   569 ITLWDIIVNSTD----VKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDY 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	169/574 (29%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	127/408 (31%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	167/565 (30%)
		dual_peroxidase_like	72..625	CDD:188652	176/610 (29%)
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910