Protein Alignment cd and Tpo

DIOPT Version :10

• Sequence 1: NP_651081.1
• Gene: cd / 42681
• FlyBaseID: FBgn0263986
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: XP_011242158.1
• Gene: Tpo / 22018
• MGIID: 98813
• Length: 915
• Species: Mus musculus
• Alignment Length: 622
• Identity: 212/622 - (34%)
• Similarity: 318/622 - (51%)
• Gaps: 80/622 - (12%)

  Fly   217 RYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAPR-----VSHHG-RLPPARQVS---L 272
            :||..||.|||:.||| :|||.....|.:.|.|.||.:.|:     ..:|| .|||.|:|:   :
Mouse   144 KYRPITGACNNRDHPR-WGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLI 207

  Fly   273 KIHRSSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEG--ESIDCCVAATREQHPECYPVDILP 335
            ::...:...|..::..|.|:||::||||..|..:||...  ..:||  ..|.|....|:|:.:
Mouse   208 QVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDC--QLTCENQNPCFPIQL-- 268

  Fly   336 DDPYYKQYNISCMNFVRSAPA-PTGRFG----------PRMQLNQATAFIDASVVYGNLEQRQNQ 389
              |.......:|:.|.||:.| .||..|          ||.|:|..|:|:|||.|||:....:.|
Mouse   269 --PSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQ 331

  Fly   390 LRSFIN--GSLRM--FVTDDGRQLLPISS---NPADGCNRVQMTRLGKYCFESGDDRANENLLLT 447
            ||::.:  |.||:  ...|.||..||.::   .|..|..|...|.    ||.:||.||:|...|.
Mouse   332 LRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTP----CFLAGDGRASEVPALA 392

  Fly   448 SMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLL 512
            ::|.||.|.||.||...:..|.||.....||||||::||....||..:::|.:||.:
Mouse   393 AVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPD-------- 449

  Fly   513 PAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAH-TLLPGLFNISRD---NSTPEAIELHKMLFNP 573
            ..:..:...:.|:|.|:|:::|.|:.|||||.| |:.|.:..::.|   ::....::|..:.|.|
Mouse   450 AFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRP 514

  Fly   574 FSLWAEHGIDHALM-TAANTPVMQVD-RFFSLEVTQKLF----EGTAEDRVPLCGLDLVSLNIQR 632
            :.|..|.|:|..:. ..|....:||. :..:.|:|::||    .||         |||.|||:||
Mouse   515 WRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGT---------LDLASLNLQR 570

  Fly   633 GRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATL-DSIRQIYESPQDVDVYTGALSEPPLDGA 696
            |||||:|.|..:|..|.|..::|..|:::||.|.:: :.|..:|:...::||:.|.|:|..|.||
Mouse   571 GRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGA 635

  Fly   697 IFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHV 761
            ..|||.:|::..|...|:.||..|:|   ....||.||..|:.|.||..:||.|: |:|||   .
Mouse   636 RTGPLFACIIGKQMKALRDGDRFWWE---NTNVFTDAQRQELEKHSLPRVICDNT-GLTRV---P 693

  Fly   762 MQRLRDGGNPH--VDCQDLEGFHFNFEPWSEKQQPQD 796
            :...|.|..|.  ..|:|:..  .:.|.|.| ..|||
Mouse   694 VDAFRIGKFPQDFESCEDIPS--MDLELWRE-TFPQD 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..762	CDD:460804	201/583 (34%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	198/596 (33%)
		CCP	730..783	CDD:153056
		EGF_CA	784..813	CDD:429571