DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and pxn-1

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	908	Identity:	263/908 - (28%)
Similarity:	389/908 - (42%)	Gaps:	237/908 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LPP--YQGPERVFPGGVSPRARRNKMRQFQCCMGITFIAIVFTALCLALVFSDSLGGADGGPSFF 83
            :||  |:||:.|                                       |.:|||     |..
Worm   406 VPPNIYEGPQSV---------------------------------------SQNLGG-----SVV 426

  Fly    84 FV--VNGSDSELAPNRPLPDEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEEG--LQPNE 144
            ||  .||:        |:||   ..|:...:.:||..|...||            ::|  |:.:.
Worm   427 FVCKANGN--------PVPD---YTWSFDGSTIGHIKGRFMVS------------DDGTELRISN 468

  Fly   145 VNTPSFRHYRSLSTNP---------------EARKLA---------------RRGYVENQA---- 175
            :......:|..::.||               |.||.|               .|..|||..
Worm   469 IEKKDEGYYSCMAGNPVGAMSADAKLTVIGGETRKAAAPQIDEELLRAIAQKARQNVENAVEKTR 533

  Fly   176 ----------TIDIAK--RFNYTKQP----------------GRSNIGWG---------PKIVLP 203
                      |.|:.:  ||:..||.                .|.::..|         ||.|..
Worm   534 KQLTQDKVTNTNDLKRLFRFSTPKQAVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSY 598

  Fly   204 DPTVLRL----------------------ECDFNARYRRSTGVCNNKQHPRTYGASMVPYRRMVS 246
            : :||.:                      :..|:.|||...|.||||..|.| |.|::|.||::.
Worm   599 E-SVLHVTHVQALMGLSGCHTGQYKNPCTDTCFHHRYRSFDGQCNNKNKPMT-GVSLMPLRRLLK 661

  Fly   247 PDYADGIAAPRVSHHGR------LPPARQVSLKIHRSSYET-DSNFTVMLAVFGQFMDHDITATS 304
            |.|.:|...|.....||      ||..|:||.::..:...| .|..:.|:..:|||:|||:|.|.
Worm   662 PVYENGFNTPVGWEKGRLYNGYPLPNVREVSRQLVATENITPHSKLSSMVMQWGQFVDHDLTHTV 726

  Fly   305 LTTSQEGESIDCCVAATREQHPECYPVDILPDDPYYKQYNIS--CMNFVRSAPAPTG-------- 359
            ...|:...:.......|.|....|:.:.:.|:||..|..:..  |:.|.||| |..|
Worm   727 TALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSGSAKYPCIEFERSA-AVCGSGETSLVF 790

  Fly   360 -RFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFI--NGSLRMFVTDD-GRQLLPISSNPADGC 420
             |...|.|:|..|:|:|||.|||:.|.:..:||...  ||.||..:|.: |::.||...:....|
Worm   791 NRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTYNNNGMLRFDITSEAGKEYLPFEKDSNMDC 855

  Fly   421 NRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILG 485
            .|.........||.:||.||||.|.|.:.|.::.|.||.:|::|:..|.:|:.|.:|.|.|||:|
Worm   856 RRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKLKSMNGNWDGEIIYHETRKIVG 920

  Fly   486 AQMAHITYNEFLPVLLG------KNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFA 544
            |.|.||||..::|::.|      |.:...:|             |||:||.|:.|.||.|||||.
Worm   921 AMMQHITYKHWMPIIFGGQAQMNKFVGTYQG-------------YDPDVDASVTNAFATAAFRFG 972

  Fly   545 HTLL-PGLFNISRDNSTPEA--IELHKMLFNPFSLWAEHGIDHALMTAANTPVM--QVDRFFSLE 604
            ||:: |.||.:..|....:.  |.|||..|.|..:..:.|:|..|.....:|:.  ...:..::|
Worm   973 HTIINPSLFRLGNDFMPIKEGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKHPMPTQLLNME 1037

  Fly   605 VTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAI-DNATL 668
            :.:|||....|     ..|||..:||||.||||:|||..:|:.|.||....||:|...| |:..:
Worm  1038 LIEKLFMKGHE-----VSLDLAVMNIQRSRDHGLPSYTEYRKFCNLPVPVQWEDMKGYIKDDMII 1097

  Fly   669 DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKA 733
            ..:|.:|..||::|::.|.:.|..|:..:|||..:|::.:||.:::.||..|||:   ...||..
Worm  1098 QKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFACIIGEQFRKIRDGDRFWYEK---DGVFTPE 1159

  Fly   734 QLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPHVD------CQDLEGFHFNFEPWSE 790
            ||.||.|.:||.:.|.|.|.|.|:::.|..      .|.:|      ||:.|  ..|...||:
Worm  1160 QLREIKKITLARLFCDNGDNIDRIQKDVFM------YPGMDKENYGTCQETE--MMNLRAWSK 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	200/569 (35%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	146/400 (37%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764
		leucine-rich repeat	35..53	CDD:275380
		LRR_8	52..112	CDD:290566
		LRR_4	53..93	CDD:289563
		leucine-rich repeat	54..77	CDD:275380
		LRR_4	77..120	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..117	CDD:275380
		LRR_8	123..182	CDD:290566
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		I-set	315..400	CDD:254352
		IGc2	328..392	CDD:197706
		IG_like	414..496	CDD:214653	25/148 (17%)
		Ig	420..496	CDD:299845	22/103 (21%)
		An_peroxidase	634..1181	CDD:281139	200/569 (35%)
		peroxidasin_like	757..1203	CDD:188658	166/473 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820