DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and hpx-2

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_506432.1	Gene:	hpx-2 / 179880	WormBaseID:	WBGene00008627	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	218/733 - (29%)
Similarity:	343/733 - (46%)	Gaps:	97/733 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VVNGSDSELAPNRPLPDEPAAEWAL--QQAALGHHDGAQAVSAGIKALGDREILEEGLQPNEVNT 147
            |:...||..:.|.  ..|..::..:  |||   :.|...|...|       |:|||.   ..:..
Worm    34 VMRALDSRASENS--ESEQTSQHIIVSQQA---NSDSKSAQFTG-------EVLEEA---TRILV 83

  Fly   148 PSFRHYRSLSTNPEARKLARRGYVENQATIDIAKRFNYTKQPGRSNIGWGPKIVLPDPT------ 206
            ..|    .|...|.|.::..|...|.:..:..::....|:.              ||||
Worm    84 REF----GLEILPAANEVIERWRNEEEELLQSSETTTTTEH--------------PDPTRSKRSA 130

  Fly   207 VLR-------------LECD--FNARYRRSTGVCNNKQHPRTYGASMVPYRRMV-SPDYADGIAA 255
            :.|             :.|:  |:...|..||:|||:|: ...|.|:.|.||:: :..||||:..
Worm   131 IFRSKRQANRRCSSPPINCNNRFHTSIRSITGLCNNRQN-SDLGNSVSPLRRILGAASYADGLGR 194

  Fly   256 PRVS--HHGRLPPARQVSLKIH--RSSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEGESIDC 316
            .|..  :.|.||.||.:|.:||  |::.....:...:..:.|||:.||:.....:.:::|.::||
Worm   195 IRTRSVNGGELPSARLISNRIHDDRNNQVFSPSINHLHMIIGQFIAHDVVFMPSSVARDGGALDC 259

  Fly   317 CVAATREQ-HPECYPVDILPDDPYYKQYNISCMNFVRSAPAPTGR--FGPRMQLNQATAFIDASV 378
            ....:.:: .|.|.|:.|..:|||   :|..||...|   |..|:  ||.|.|:.|.:.|:|.|.
Worm   260 SACNSPQRVSPNCAPITIPRNDPY---FNTPCMRLTR---ALNGQENFGVRSQIGQNSHFLDLSP 318

  Fly   379 VYGNLEQRQNQLRSFINGSLRMFVTDD-GRQLLPISSNPADGCNRVQMTRLGKYCFESGDDRANE 442
            |||:.:.....:|||..|  :|...|| |..|.|.::|.:: |    .:....:||..||.|.:.
Worm   319 VYGSADCEAETVRSFQEG--KMLTFDDLGYTLPPQNANDSN-C----QSSAPFHCFTCGDFRNSL 376

  Fly   443 NLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISE 507
            :..|..:|.:..:.||.||.|::...|.:.||:::|..|||:.....||.|||::|..|.:....
Worm   377 HPALIPVHTILIKEHNRLAEQVRVARPRFNDEQIFQLVRKIMIGMWQHIVYNEYIPKYLPRRTIR 441

  Fly   508 AKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLLPGLFNISR--DNSTPEA-IELHKM 569
            ...|.|.::.::.  .|...|||||:..||.|||||.|:  ...|:..|  :|..|.. .:|...
Worm   442 NFALRPLRNGVHR--GYSTSVDPSISAEFAGAAFRFGHS--QSRFDFPRLTENGRPAGNYDLGND 502

  Fly   570 LFNPFSLWAEH--GIDHALMTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQR 632
            :|....::...  |.:..:......|.|:.||:||..:..::||....:.   .|:||||:||||
Worm   503 IFYADQMYLTRIGGWEPVMNGMVRMPAMKSDRYFSFGIRNQMFEIRGRNG---SGVDLVSINIQR 564

  Fly   633 GRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATLDSIRQIYESPQDVDVYTGALSEPPLDGAI 697
            |||.|:..|..:|:...||||.::.|::.......:.::|.:|..|.|:|:|.|.:.|.||.|..
Worm   565 GRDMGLFPYIQYRQLVGLPTVTSFNELNTTFSQENIQALRNVYSDPADIDLYVGIMLEEPLSGGQ 629

  Fly   698 FGPLLSCMVSDQFLRLKLGDSHWYER-KMGPQKFTKAQLAEI-YKTSLAAIICRNSDGITRVREH 760
            .||..|.|:.:||..||.||..:||. ..|...||:.:::|: .|||||.|||.|.|...|:...
Worm   630 LGPTASFMIGEQFRALKRGDRFFYESIAEGTDNFTQEEISELRNKTSLAKIICTNMDFAARINTD 694

  Fly   761 VMQRLRDGGNPHVDCQDL 778
            :.    |..:..|.|..|
Worm   695 IF----DHRSRQVACTSL 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	184/552 (33%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	133/393 (34%)
hpx-2	NP_506432.1	An_peroxidase	158..696	CDD:376988	185/558 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49305
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.890