DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and tpo

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	XP_031758614.1	Gene:	tpo / 100036738	XenbaseID:	XB-GENE-920152	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	240/736 - (32%)
Similarity:	364/736 - (49%)	Gaps:	112/736 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 IKALGDREILEEGLQPNEVNTPSFRHYRSLSTNPEARKLARRGYVENQATIDIAKRFNYTKQPGR 191
            :|:.|..::.|..:..|..:..|..|   |...|:: .|.|     |.:..|......:.:....
Frog    10 VKSNGTSQVKEVCVFENNTDQNSVFH---LDNIPQS-ALPR-----NSSQTDKTSLEQHPESEDV 65

  Fly   192 SNIGWGPKIVLPD-----PTVLRLECDFN---ARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPD 248
            |:.|...:.||.:     |..|...|..|   .:||..||.|||:.:| .:||:.....|.:...
Frog    66 SHTGSSFEAVLANLTGCVPQTLSPFCPNNCLAGKYRHITGACNNRNNP-AWGAANTLLARWLPAQ 129

  Fly   249 YADGIAAPR-----VSHHG-RLPPARQVSLK-IHRSS--YETDSNFTVMLAVFGQFMDHDITATS 304
            |.|||..|:     ..::| |||..|:|:.| ||.||  :..|..::.::..:||::||||..|.
Frog   130 YEDGIGEPKGWREEFLYNGFRLPQVREVTNKIIHASSKAFREDDLYSHIIIEWGQYIDHDIAFTP 194

  Fly   305 LTTSQEGE--SIDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAPA-PTGRFG---- 362
            .:.|:...  |:||  .:|.|....|||:.:..:||..:.   .|:.|.||:.| .|||.|
Frog   195 QSVSKTPAIGSVDC--KSTCENLYPCYPIKLSEEDPLSQG---GCIPFYRSSSACGTGRGGLKFG 254

  Fly   363 ------PRMQLNQATAFIDASVVYGNLEQRQNQLRSFIN--GSLRMFV--TDDGRQLLPISS--- 414
                  ||.|:|..|:|||||.|||:.|..|::|::..:  |.||:.|  :|..|:.||..:
Frog   255 NPSLLNPREQINGLTSFIDASTVYGSSESLQHKLKNLSSEEGLLRVNVKYSDSSREYLPFETPSA 319

  Fly   415 ---NP-ADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDER 475
               :| ||...|:.       ||.:|:.||||.:.|.::|.||.|.||.:|:.|::.||||..|.
Frog   320 CMQDPTADNAERID-------CFFAGEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNSET 377

  Fly   476 LYQEARKILGAQMAHITYNEFLPVLLGK-----NISEAKGLLPAKHNLNAPDTYDPEVDPSIANC 535
            .|||||||:||....||:.:::|.:|||     .|...||             |:.:.:|||:|.
Frog   378 TYQEARKIVGALHQIITFRDYMPKILGKAAYDQYIGLYKG-------------YNQKTNPSISNI 429

  Fly   536 FAAAAFRFAHTLLPGLFNISRDNS----TPE--AIELHKMLFNPFSLWAEHGID---HALMTAAN 591
            |..|||||.|..:|.:  :.|.||    .|:  ::.|:::.|.|:.:..|.|:|   ..|:..:.
Frog   430 FTTAAFRFGHATIPPM--VHRLNSQYVDDPKYPSLPLNEVFFRPWRIVKEGGLDPLIRGLLGKSA 492

  Fly   592 TPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTW 656
            ....||| ..:.|:|:||...|...     .:||.|||:|||||||:|.|..:|..|.|..:.|.
Frog   493 KLQTQVD-MINEELTEKLLVMTNNG-----SMDLASLNLQRGRDHGLPGYNDWREFCGLSRLATP 551

  Fly   657 EEMSQAI-DNATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHW 720
            .::..|: |...:..:..:|..|.::||:.|.|:|..|.||..|||.:|::..|...|:.||..|
Frog   552 ADLINAVSDQKLVAKMIALYSHPDNIDVWLGGLAEDFLPGARTGPLFACLIGKQMQALREGDRFW 616

  Fly   721 YERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNP--HVDCQDLEGFHF 783
            ||..   ..|||.|.:|:.|.||:.:||.|: |::.|   .:.....|..|  .|.|..:.|  .
Frog   617 YENN---NIFTKIQRSELEKHSLSRVICDNT-GLSHV---PLDAFLLGNYPDNFVSCDSIPG--I 672

  Fly   784 NFEPWSEKQQPQDLHSAGISR 804
            |.|.|  |:.|:...:.|..|
Frog   673 NLEAW--KESPEKGTTCGSPR 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	207/584 (35%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	149/411 (36%)
tpo	XP_031758614.1	thyroid_peroxidase	116..679	CDD:188657	208/606 (34%)
		CCP	687..736	CDD:153056	2/5 (40%)
		EGF_CA	738..781	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2438
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.060