Protein Alignment cd and tpo

DIOPT Version :10

• Sequence 1: NP_651081.1
• Gene: cd / 42681
• FlyBaseID: FBgn0263986
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: XP_031758614.1
• Gene: tpo / 100036738
• XenbaseID: XB-GENE-920152
• Length: 872
• Species: Xenopus tropicalis
• Alignment Length: 736
• Identity: 240/736 - (32%)
• Similarity: 364/736 - (49%)
• Gaps: 112/736 - (15%)

  Fly   127 IKALGDREILEEGLQPNEVNTPSFRHYRSLSTNPEARKLARRGYVENQATIDIAKRFNYTKQPGR 191
            :|:.|..::.|..:..|..:..|..|   |...|:: .|.|     |.:..|......:.:....
 Frog    10 VKSNGTSQVKEVCVFENNTDQNSVFH---LDNIPQS-ALPR-----NSSQTDKTSLEQHPESEDV 65

  Fly   192 SNIGWGPKIVLPD-----PTVLRLECDFN---ARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPD 248
            |:.|...:.||.:     |..|...|..|   .:||..||.|||:.:| .:||:.....|.:...
 Frog    66 SHTGSSFEAVLANLTGCVPQTLSPFCPNNCLAGKYRHITGACNNRNNP-AWGAANTLLARWLPAQ 129

  Fly   249 YADGIAAPR-----VSHHG-RLPPARQVSLK-IHRSS--YETDSNFTVMLAVFGQFMDHDITATS 304
            |.|||..|:     ..::| |||..|:|:.| ||.||  :..|..::.::..:||::||||..|.
 Frog   130 YEDGIGEPKGWREEFLYNGFRLPQVREVTNKIIHASSKAFREDDLYSHIIIEWGQYIDHDIAFTP 194

  Fly   305 LTTSQEGE--SIDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAPA-PTGRFG---- 362
            .:.|:...  |:||  .:|.|....|||:.:..:||..:.   .|:.|.||:.| .|||.|
 Frog   195 QSVSKTPAIGSVDC--KSTCENLYPCYPIKLSEEDPLSQG---GCIPFYRSSSACGTGRGGLKFG 254

  Fly   363 ------PRMQLNQATAFIDASVVYGNLEQRQNQLRSFIN--GSLRMFV--TDDGRQLLPISS--- 414
                  ||.|:|..|:|||||.|||:.|..|::|::..:  |.||:.|  :|..|:.||..:
 Frog   255 NPSLLNPREQINGLTSFIDASTVYGSSESLQHKLKNLSSEEGLLRVNVKYSDSSREYLPFETPSA 319

  Fly   415 ---NP-ADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDER 475
               :| ||...|:.       ||.:|:.||||.:.|.::|.||.|.||.:|:.|::.||||..|.
 Frog   320 CMQDPTADNAERID-------CFFAGEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNSET 377

  Fly   476 LYQEARKILGAQMAHITYNEFLPVLLGK-----NISEAKGLLPAKHNLNAPDTYDPEVDPSIANC 535
            .|||||||:||....||:.:::|.:|||     .|...||             |:.:.:|||:|.
 Frog   378 TYQEARKIVGALHQIITFRDYMPKILGKAAYDQYIGLYKG-------------YNQKTNPSISNI 429

  Fly   536 FAAAAFRFAHTLLPGLFNISRDNS----TPE--AIELHKMLFNPFSLWAEHGID---HALMTAAN 591
            |..|||||.|..:|.:  :.|.||    .|:  ::.|:::.|.|:.:..|.|:|   ..|:..:.
 Frog   430 FTTAAFRFGHATIPPM--VHRLNSQYVDDPKYPSLPLNEVFFRPWRIVKEGGLDPLIRGLLGKSA 492

  Fly   592 TPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTW 656
            ....||| ..:.|:|:||...|...     .:||.|||:|||||||:|.|..:|..|.|..:.|.
 Frog   493 KLQTQVD-MINEELTEKLLVMTNNG-----SMDLASLNLQRGRDHGLPGYNDWREFCGLSRLATP 551

  Fly   657 EEMSQAI-DNATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHW 720
            .::..|: |...:..:..:|..|.::||:.|.|:|..|.||..|||.:|::..|...|:.||..|
 Frog   552 ADLINAVSDQKLVAKMIALYSHPDNIDVWLGGLAEDFLPGARTGPLFACLIGKQMQALREGDRFW 616

  Fly   721 YERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNP--HVDCQDLEGFHF 783
            ||..   ..|||.|.:|:.|.||:.:||.|: |::.|   .:.....|..|  .|.|..:.|  .
 Frog   617 YENN---NIFTKIQRSELEKHSLSRVICDNT-GLSHV---PLDAFLLGNYPDNFVSCDSIPG--I 672

  Fly   784 NFEPWSEKQQPQDLHSAGISR 804
            |.|.|  |:.|:...:.|..|
 Frog   673 NLEAW--KESPEKGTTCGSPR 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..762	CDD:460804	208/591 (35%)
tpo	XP_031758614.1	thyroid_peroxidase	116..679	CDD:188657	208/606 (34%)
		CCP	687..736	CDD:153056	2/5 (40%)
		EGF_CA	738..781	CDD:214542