Protein Alignment Nup133 and NUP133

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_013008.3
• Gene: NUP133 / 853957
• SGDID: S000001790
• Length: 1157
• Species: Saccharomyces cerevisiae
• Alignment Length: 1212
• Identity: 229/1212 - (18%)
• Similarity: 418/1212 - (34%)
• Gaps: 336/1212 - (27%)

  Fly   112 QNGWAWVVQGRRLLIWQYKDTAKSGSPPRVGKLARRGGGLAQCRELTLPYSDLGHKSD------- 169
            |.|:..|...:::.||....|.|.                       .||..:..:||
Yeast    93 QIGYGLVNDHKKVYIWNIHSTQKD-----------------------TPYITVPFRSDDNDEIAV 134

  Fly   170 ---------------LISVFQTEGQQMASCIAVSATGEVRYWSSIAHDGNSV-DLSILTGQEFVQ 218
                           .:::...:..:....|.:..:..:.|     .|.||: :|:....::|..
Yeast   135 APRCILTFPATMDESPLALNPNDQDETGGLIIIKGSKAIYY-----EDINSINNLNFKLSEKFSH 194

  Fly   219 LLSLPTQQ---------------GYLAVTTTCNLVFLRVGLTNGRYTLH-----HKTIKPATSFL 263
            .|.||...               |.:..|....:.|:.:..:.|:..|.     :|..|     |
Yeast   195 ELELPINSSGGEKCDLMLNCEPAGIVLSTNMGRIFFITIRNSMGKPQLKLGKLLNKPFK-----L 254

  Fly   264 GGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAI-QRWSLS-NNGNTENLL 326
            |.:.|.|       ||    :.::|.:.....|..|..:|.:.:::.| |.|.|| .|.:...|:
Yeast   255 GIWSKIF-------NT----NSSVVSLRNGPILGKGTRLVYITTNKGIFQTWQLSATNSHPTKLI 308

  Fly   327 YEDADMLRRIREEFITNFWKFRLPADSLEIDLHLLDFHVVKNK-AYILAGAVNAAHAPQMCYALV 390
              |.::...|.|. :.:.:.|      ....|.:.|.|.:::: :.:...::..:...:..|.|.
Yeast   309 --DVNIYEAILES-LQDLYPF------AHGTLKIWDSHPLQDESSQLFLSSIYDSSCNETYYILS 364

  Fly   391 TGTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVVGSSHIYLYTSKVVYPLHLTNSVPTAEL 455
            |....:.......|:...:|.|..:.|:..               :..|:..| .:.|:..|.|:
Yeast   365 TIIFDSSSNSFTIFSTYRLNTFMESITDTK---------------FKPKIFIP-QMENANDTNEV 413

  Fly   456 EAEKIEFHQHDDRILSAVICSQLPLFFS---RTHGLVSITPGDFDGTEMMNMSSCNTPDLYAPNS 517
            .:..:.|   .:.::...:.|:|...:|   :...:||:. .|.|    :..|..::..||
Yeast   414 TSILVMF---PNAVVITQVNSKLDSSYSMRRKWEDIVSLR-NDID----IIGSGYDSKSLY---- 466

  Fly   518 CNASFAVADHSALTNSTNNLHLFELDPDEMYNELSDEVGQLKA---AFLYHMKRNSNMVKTIVDE 579
                       .||.....|..|..:.:|..::  .|||.:|:   ..:|..|.|:|
Yeast   467 -----------VLTKQMGVLQFFVKENEETNSK--PEVGFVKSHVDQAVYFSKINAN-------- 510

  Fly   580 LLRNVTAADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEEALADQEMNRHAIGSSRSMQII 644
                         |:| :.|...:....|.:..|:.:..   ||..       |:.| .....::
Yeast   511 -------------PID-FNLPPEISLDQESIEHDLKLTS---EEIF-------HSNG-KYIPPML 550

  Fly   645 NQLRDKIIA----FQHFITFLHSSLVW-----------DKLNVIPC--GSHSLKPTGCILADISE 692
            |.|...:..    ||:|:||:..:..:           :|..::.|  ..:|:.....:|.||.|
Yeast   551 NTLGQHLSVRKEFFQNFLTFVAKNFNYKISPELKLDLIEKFEILNCCIKFNSIIRQSDVLNDIWE 615

  Fly   693 KIVAAMAL---RSIQTKLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQN--VFEALAD 752
            |.::...|   ..:.||           ||.:  ..|       |:|.|...:|.|  ||..
Yeast   616 KTLSNYNLTQNEHLTTK-----------TVVI--NSP-------DVFPVIFKQFLNHVVFVL--- 657

  Fly   753 IADDRIAAQNQT-TISVAHFVNE-INSIVLDVLGQVFKYRKQHASSFRLSHEKLPSYENLPW--- 812
                 ..:|||. .::|.:.:|. ....:|:...:..:|.........:...|||.:.|..:
Yeast   658 -----FPSQNQNFKLNVTNLINLCFYDGILEEGEKTIRYELLELDPMEVDTSKLPWFINFDYLNC 717

  Fly   813 --------TAMAGSAGVRDT----LTRLIDISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRK 865
                    |......|..|:    |.:::.|                 ||.| |....:.::.:.
Yeast   718 INQCFFDFTFACEEEGSLDSYKEGLLKIVKI-----------------LYYQ-FNQFKIWINTQP 764

  Fly   866 TYLKSVRDTEKFNVLQQQFEAQRRELISVLIKDRQYEYAAKIAEKYLDFQSLV--LICDETQDKE 928
              :|||...:.|..:...::....:...||.|....|...:|||.|.|...||  |...:..|..
Yeast   765 --VKSVNANDNFININNLYDDNHLDWNHVLCKVNLKEQCIQIAEFYKDLSGLVQTLQTLDQNDST 827

  Fly   929 RLEDYTRKYEEY--DFSQFAINWHLRQNRHGEVFERFKGNQTALAQFMRDH-PSLG---WIQLIF 987
            .:..|...:.|:  :||.....:.::..:..::..||......|.||.::. |..|   |||.|.
Yeast   828 TVSLYETFFNEFPKEFSFTLFEYLIKHKKLNDLIFRFPQQHDVLIQFFQESAPKYGHVAWIQQIL 892

  Fly   988 NGDFERAAKVL-----------YELAQCETEFVARKKSMLSLAKLAAFAAAESDLTAQ-VEKINA 1040
            :|.:..|...|           ..|::||..        |::|||::....:.:|... :.||..
Yeast   893 DGSYADAMNTLKNITVDDSKKGESLSECELH--------LNVAKLSSLLVEKDNLDINTLRKIQY 949

  Fly  1041 DLTLVEYQSQLGH----------------DVLESFGFDPAEQK---VLKAEEIISLYIAEENETA 1086
            :|..::.:..:.:                .:.|.|.....|.|   |:...:::.||...::|
Yeast   950 NLDTIDAEKNISNKLKKGEVQICKRFKNGSIREVFNILVEELKSTTVVNLSDLVELYSMLDDE-- 1012

  Fly  1087 SETEFRKALELLSYVEQPYDMRHKIWCAAIKRDNWTDYDPNNAVHYMQKLLFYKIIEISQLMGND 1151
             |:.| ..|.|||......:...|.:..|:.   |......||.:...|||.:.:..:.     |
Yeast  1013 -ESLF-IPLRLLSVDGNLLNFEVKKFLNALV---WRRIVLLNASNEGDKLLQHIVKRVF-----D 1067

  Fly  1152 SENVLPPMEDF-LESVELGDLPQQKPFQYLLKLTYEYVADMF 1192
            .|  ||...|| |.||   ||...|..     ||.||:::.:
Yeast  1068 EE--LPKNNDFPLPSV---DLLCDKSL-----LTPEYISETY 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	68/425 (16%)
		Nucleoporin_C	767..1122	CDD:427181	79/409 (19%)
NUP133	NP_013008.3	Nucleoporin_N	62..475	CDD:400932	77/473 (16%)
		Nucleoporin_C	<759..1049	CDD:427181	63/306 (21%)