Protein Alignment Nup133 and NUP133

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_060700.2
• Gene: NUP133 / 55746
• HGNCID: 18016
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1228
• Identity: 335/1228 - (27%)
• Similarity: 585/1228 - (47%)
• Gaps: 140/1228 - (11%)

  Fly    14 RESSPGARRYSMPAASADST-----RKSI-FGGSASCAQMSGSLKRTALTNSRLSLSVRSTQSIA 72
            |....|:||..:......||     ||.: .|.:.|...:...:.|      |.|||.|.|.:..
Human     9 RTPGTGSRRGPLAGLGPGSTPRTASRKGLPLGSAVSSPVLFSPVGR------RSSLSSRGTPTRM 67

  Fly    73 ----GIRSDYN-SVESFGCPLPVVVNEALTFAGPGAGTVTAKVTQNGWAWVVQGRRLLIWQYKDT 132
                .|....| .|::||..|||.|.||||.|... ..:|..:.:.|||.:|...:|:||:.
Human    68 FPHHSITESVNYDVKTFGSSLPVKVMEALTLAEVD-DQLTINIDEGGWACLVCKEKLIIWKI--- 128

  Fly   133 AKSGSPPRVGKLARRGGGLAQCRELTLPYSDLGHKSDLISVF------QTEGQQMASCIAVSATG 191
              :.||  :.|       |:.|:||.||.||....:||:::.      :....|..:.:..:..|
Human   129 --ALSP--ITK-------LSVCKELQLPPSDFHWSADLVALSYSSPSGEAHSTQAVAVMVATREG 182

  Fly   192 EVRYWSSIAHDGNSVDLSILTGQEFVQLLSLPTQQGYLAVTTTCNLVFLRVGLTNGRYTLHHKTI 256
            .:|||.|:|.:....:..:.:|.:.........|.|...::::.:.:...:..::|:  :|...:
Human   183 SIRYWPSLAGEDTYTEAFVDSGGDKTYSFLTAVQGGSFILSSSGSQLIRLIPESSGK--IHQHIL 245

  Fly   257 KPATSFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRA----------- 310
            ......|.|.|:|.:|              |.|:...|   |..|:.:||.||.
Human   246 PQGQGMLSGIGRKVSS--------------LFGILSPS---SDLTLSSVLWDRERSSFYSLTSSN 293

  Fly   311 IQRWSLSNNGNTENLLYEDADMLRRIREEFITNFWKFRLPADSLE--IDLHLLDFHVVKNKAYIL 373
            |.:|.|.:  ::|...| ..|:.|.::|......|......::::  :::..||.....:...||
Human   294 ISKWELDD--SSEKHAY-SWDINRALKENITDAIWGSESNYEAIKEGVNIRYLDLKQNCDGLVIL 355

  Fly   374 AGAVNAAHAPQMC-YALVT----GTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVV---GS 430
            |.|.::|..|.:. |:|:|    |...::.:.:|      :.::......||.:..:..|   .:
Human   356 AAAWHSADNPCLIYYSLITIEDNGCQMSDAVTVE------VTQYNPPFQSEDLILCQLTVPNFSN 414

  Fly   431 SHIYLYTSKVVYPLHLTNSVPTAE--LEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITP 493
            ...|||....||    ..|..|.:  |..|||.|:...|.:|.|..|..:|:.|||..||||||.
Human   415 QTAYLYNESAVY----VCSTGTGKFSLPQEKIVFNAQGDSVLGAGACGGVPIIFSRNSGLVSITS 475

  Fly   494 GDFDGTEMMNMSSCNTPDLYAPNSCNASFAVADHSALTNSTNNLHLFELDPDEMYNELSDEVGQL 558
            .:.......::.......:..|||.:..|        ..:|.|..:.:          .|::..|
Human   476 RENVSILAEDLEGSLASSVAGPNSESMIF--------ETTTKNETIAQ----------EDKIKLL 522

  Fly   559 KAAFLYHMKRNSNMVKTIVDELLRNVTAADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEE 623
            |||||.:.:::....:.:||||..:.:..|...      :|||.|..|:.||.:|.|.:||||.|
Human   523 KAAFLQYCRKDLGHAQMVVDELFSSHSDLDSDS------ELDRAVTQISVDLMDDYPASDPRWAE 581

  Fly   624 ALADQEMNRHAIG-SSRSMQIINQLRDKIIAFQHFITFLHSSLVWDKLNVIPCGSHSLKPTGCIL 687
            ::.::     |.| |:.|:.|::||.||:.|....:.|:|...::.:|...|.....: .|..:|
Human   582 SVPEE-----APGFSNTSLIILHQLEDKMKAHSFLMDFIHQVGLFGRLGSFPVRGTPM-ATRLLL 640

  Fly   688 ADISEKIVAAMALRSIQTKLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQNVFEALAD 752
            .:.:||:.||:.|::..::|..|:..||...:.....|...:||..|:|:.::|:...:.|.|.:
Human   641 CEHAEKLSAAIVLKNHHSRLSDLVNTAILIALNKREYEIPSNLTPADVFFREVSQVDTICECLLE 705

  Fly   753 IADDRIAAQNQTTISVAHFVNEINSIVLDVLGQVFKYRKQHASSFRL--SHEKLPSYENLPWTAM 815
            ..:..:......:|..|..|..:|:|:.|:|.....||:...|.:|.  |.||.|.|  :||||.
Human   706 HEEQVLRDAPMDSIEWAEVVINVNNILKDMLQAASHYRQNRNSLYRREESLEKEPEY--VPWTAT 768

  Fly   816 AGSAGVRDTLTRLIDISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSV---RDTEKF 877
            :|..|:|..:.|..:|.::. ::..:::.|:..:.:|:..|||..|||..:.||||   .:.|::
Human   769 SGPGGIRTVIIRQHEIVLKV-AYPQADSNLRNIVTEQLVALIDCFLDGYVSQLKSVDKSSNRERY 832

  Fly   878 NVLQQQFEAQRRELISVLIKDRQYEYAAKIAEKYLDFQSLVLICDETQDKERLEDYTRKYEEYDF 942
            :.|:.::..:|.:|:|.|:...||.:||.:||||.||..||.:|::|.::.||:.|..::.:.:|
Human   833 DNLEMEYLQKRSDLLSPLLSLGQYLWAASLAEKYCDFDILVQMCEQTDNQSRLQRYMTQFADQNF 897

  Fly   943 SQFAINWHLRQNRHGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETE 1007
            |.|...|:|.:.:.|::..:.......||.|::.|..|.|:..|.:.:.|:|...|..||..||.
Human   898 SDFLFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHATLLGLANMETR 962

  Fly  1008 FVARKKSMLSLAKLAAFAA--AESDLTAQVEKINADLTLVEYQSQLGHDVLESFGFDPAEQKVLK 1070
            :.|:||::|.|:||||.|:  :|..|..::|::......:.:|..|...:|.....:.:...||.
Human   963 YFAKKKTLLGLSKLAALASDFSEDMLQEKIEEMAEQERFLLHQETLPEQLLAEKQLNLSAMPVLT 1027

  Fly  1071 AEEIISLYIAEENETASETEFRKALELLSYVEQP-----YDMRHKIWCAAIKRDNWTDYD-PNNA 1129
            |.::|.|||.|||..|:|.:|:|||:||.|:::.     .|::.:|.|.|::||||:..| .::.
Human  1028 APQLIGLYICEENRRANEYDFKKALDLLEYIDEEEDININDLKLEILCKALQRDNWSSSDGKDDP 1092

  Fly  1130 VHYMQKLLFYKIIEISQLMGNDSENVLPPMEDFLESVELGDLPQQKPFQYLLKLTYEY 1187
            :...:..:|.||::.....|......||.::|.|::.:||.|.....|:::||..|||
Human  1093 IEVSKDSIFVKILQKLLKDGIQLSEYLPEVKDLLQADQLGSLKSNPYFEFVLKANYEY 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	102/430 (24%)
		Nucleoporin_C	767..1122	CDD:427181	121/366 (33%)
NUP133	NP_060700.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		8/29 (28%)
		Nucleoporin_C	595..1098	CDD:427181	153/506 (30%)