Protein Alignment Nup133 and Nup133

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_001387884.1
• Gene: Nup133 / 292085
• RGDID: 1307827
• Length: 1154
• Species: Rattus norvegicus
• Alignment Length: 1229
• Identity: 341/1229 - (27%)
• Similarity: 586/1229 - (47%)
• Gaps: 136/1229 - (11%)

  Fly    11 GIS--RESSPGARRYSM----PAASADSTRKSIFGGSASCAQMSGSLKRTALTNSRLSLSVRSTQ 69
            |:|  |...||.||..:    |:.:..::|:.:..|||..:.:..|     ....|.|:|.|.|.
  Rat     4 GVSSPRTPGPGTRRGPLVGIGPSTTPRASRRGLSLGSAVSSPVLFS-----PVGRRSSVSSRGTP 63

  Fly    70 S----IAGIRSDYN-SVESFGCPLPVVVNEALTFAGPGAGTVTAKVTQNGWAWVVQGRRLLIWQY 129
            :    ...|....| .|..||..|||.:.|||..| .....::..|.:.|||.:|...:||:|:.
  Rat    64 TRIFPYHSISESVNYDVRVFGSSLPVKIMEALAMA-EADDQLSVHVDEGGWACLVCKEKLLVWKI 127

  Fly   130 KDTAKSGSPPRVGKLARRGGGLAQCRELTLPYSDLGHKSDLI--SVFQTEGQ----QMASCIAVS 188
                 :.||  |.|       |:.|::|.||.||....:||:  |...|.|:    |..|.:..:
  Rat   128 -----AMSP--VTK-------LSVCKDLQLPPSDFHWSADLVALSYAATSGEVHSVQAVSVMVAT 178

  Fly   189 ATGEVRYWSSIAHDGNSVDLSI-LTGQEFVQLLSLPTQQGYLAVTTTCNLVFLRVGLTNGRYTLH 252
            ..|.:|||.|:|.:....|.|: |.|::..:.|:......::..:....||.|   :..|...:|
  Rat   179 KEGSIRYWPSLAREDTYSDTSVDLGGEKVCRFLTAVQGGSFILSSVGSQLVRL---IPEGSGKIH 240

  Fly   253 HKTIKPATSFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAIQRWSLS 317
            ...:......|.|.|::.:|:...::..:|.      |......:.|.:....|:...|.:|.|.
  Rat   241 QHVLPQGQGMLSGIGRRVSSLFGILSPTSDL------MLASVLWDRGNSSFYTLTSSNISKWELD 299

  Fly   318 NNGNTENLLYEDADMLRRIREEFITNFWKFRLPADSLE--IDLHLLDFHVVKNKAYILAGAVNAA 380
            :  ::|..:| ..||.|.::|......|......::::  :.:..||.....:...|||.|.:..
  Rat   300 D--SSEKQVY-SWDMHRALKESITDAIWGSESNYEAIKEGVSIQYLDLKQNCDGLLILAAAWHLG 361

  Fly   381 HAPQMCYALVTGTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVV---GSSHIYLYTSKVVY 442
            .:|.:.|..|.........:.::.| :.:.::......||.::.|.:|   .|...|||....|:
  Rat   362 DSPCLVYYSVITVEDNGNQMSDAVT-VEVTQYNPPFQSEDLVACRLMVPDFPSQMTYLYMESAVF 425

  Fly   443 PLHLTNSVPTAELEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITPGDFDGTEMMNMSSC 507
            .  .:.......|..|||.|....|.||.|..|..:|:.|||..||||:||     .|.|::.:.
  Rat   426 V--CSTGTGKVSLPQEKIVFDTQGDGILGAGSCGGVPILFSRNSGLVSVTP-----RESMSLLAE 483

  Fly   508 NTPDLYAPNSCNASFAVADHSALTNSTNNLHLFELDPDEMYNELSDEVGQLKAAFLYHMKRNSNM 572
            ...:..|    ::.......|.:..:|.|        |...:|  |:...||.|||.:.:::...
  Rat   484 GLEESLA----SSGGGRGSESMVFETTKN--------DTAAHE--DKTKLLKTAFLQYCRKDLGR 534

  Fly   573 VKTIVDELLRNVT--AADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEEALADQEMNRHAI 635
            .:.:.|||..:.|  .:||        :||:.|..|:.||.:|.|.:||||.|::..:     |.
  Rat   535 AQMMADELFSSHTDLESDP--------ELDKAVTQISVDLIDDYPASDPRWAESVPQE-----AP 586

  Fly   636 G-SSRSMQIINQLRDKIIAFQHFITFLHSSLVWDKLNVIPCGSHSLKPTGCILADISEKIVAAMA 699
            | |:.|:.:::||.||:.|....:.|||...::.:|:..|.....: .|..:|.:.:||:.||:.
  Rat   587 GLSNTSLIVLHQLEDKMKAHCLLVDFLHQVGLFRRLDSYPIRGTPM-TTRLLLCEHAEKLSAAIT 650

  Fly   700 LRSIQTKLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQNVFEALAD-----IADDRIA 759
            |::..::||.|:..||...:.....|...|||..|:|:.::|:...:.|.|.:     :.|..:.
  Rat   651 LKNHHSRLPDLVNAAILLALNKRECEVPPSLTPADVFFREVSQVDTICECLLEHEEQVLRDVALV 715

  Fly   760 AQNQTTISVAHFVNEINSIVLDVLGQVFKYRKQHASSFRLSHE----KLPSYENLPWTAMAGSAG 820
            :|....:::     ::|:::.|:|.....||....|.:  |.|    |.|.|  :||||.:|.:|
  Rat   716 SQEWAEVAI-----DVNTVLKDMLQAAAHYRLNKGSMY--SREEPLGKEPEY--VPWTATSGPSG 771

  Fly   821 VRDTLTRLIDISVR--YGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSVR---DTEKFNVL 880
            :|..:.|...|.::  |..   :::.|:..:.:|:..|||..||...:.|||:.   |.|:::.|
  Rat   772 IRTVIMRQHGIILKTVYPQ---ADSNLRSIVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSL 833

  Fly   881 QQQFEAQRRELISVLIKDRQYEYAAKIAEKYLDFQSLVLICDETQDKERLEDYTRKYEEYDFSQF 945
            :.::..:|.||:|.|:...||.:||.:||||.||..||.:|::|.::.||:.|..::.:.:||.|
  Rat   834 EVEYLQKRSELLSPLLTLGQYPWAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDF 898

  Fly   946 AINWHLRQNRHGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETEFVA 1010
            ...|:|.:.:.|::..:.......||.|::.|..|.|:..|.:.:.|:|...|..||..||.:.|
  Rat   899 LFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFA 963

  Fly  1011 RKKSMLSLAKLAAFAAAESDLTAQVEKINADLTLVE------YQSQLGHDVLESFGFDPAEQKVL 1069
            :||::|.|:||||.|:..|:.|.| |||.|   :.|      :|..|...:|.......:...||
  Rat   964 KKKTLLGLSKLAALASDLSEDTLQ-EKIEA---MAEQERFLLHQETLPEQLLTERQLSLSAMPVL 1024

  Fly  1070 KAEEIISLYIAEENETASETEFRKALELLSYVEQPY-----DMRHKIWCAAIKRDNWTDYD-PNN 1128
            .|.::|||||.|||..|:|.:|:|||:||.|:::..     |::.:|.|.|::||:|:..| .::
  Rat  1025 TAPQLISLYICEENRRANEYDFKKALDLLEYIDEEEDVNIDDLKLEILCRALQRDDWSGSDGRDD 1089

  Fly  1129 AVHYMQKLLFYKIIEISQLMGNDSENVLPPMEDFLESVELGDLPQQKPFQYLLKLTYEY 1187
            .:...:..:|.||::.....|......||.::|.|::.:||.|.....|:::||..|||
  Rat  1090 PIEVSKDSVFVKILQKLIKDGVQLSEYLPEVKDLLQAEQLGSLKSNSYFEFVLKANYEY 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	101/413 (24%)
		Nucleoporin_C	767..1122	CDD:427181	123/374 (33%)
Nup133	NP_001387884.1	Nucleoporin_C	597..>996	CDD:427181	120/413 (29%)