Protein Alignment Nup133 and Nup133

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_758492.2
• Gene: Nup133 / 234865
• MGIID: 2442620
• Length: 1155
• Species: Mus musculus
• Alignment Length: 1220
• Identity: 335/1220 - (27%)
• Similarity: 584/1220 - (47%)
• Gaps: 125/1220 - (10%)

  Fly    14 RESSPGARRYSM----PAASADSTRKSIFGGSA--SCAQMSGSLKRTALTNSRLSLSVRSTQSIA 72
            |...||.||..:    |.::..::|:.:..|||  |....|.:.:|:::::......:....||:
Mouse     9 RTPGPGTRRGPLVGIGPTSTPRASRRGLSLGSAVNSPVLFSPAGRRSSVSSRGTPTRIFPHHSIS 73

  Fly    73 GIRSDYNSVESFGCPLPVVVNEALTFAGPGAGTVTAKVTQNGWAWVVQGRRLLIWQYKDTAKSGS 137
              .|....|..||..|||.:.||||.| .....::..|.:.|||.:|...:||||:.     :.|
Mouse    74 --ESVNYDVRVFGSSLPVKIMEALTMA-EADEQLSVHVDEGGWACLVCTEKLLIWKI-----AVS 130

  Fly   138 PPRVGKLARRGGGLAQCRELTLPYSDLGHKSDLI--SVFQTEGQ----QMASCIAVSATGEVRYW 196
            |  |.|       |:.|:||.||.||....:||:  |...|.|:    |..|.:..:..|.:|||
Mouse   131 P--VTK-------LSVCKELQLPPSDFHGSADLVALSYAATSGEVHSVQAVSVMVATKEGSIRYW 186

  Fly   197 SSIAHDGNSVDLSI-LTGQEFVQLLSLPTQQGYLAVTTTCNLVFLRVGLTNGRYTLHHKTIKPAT 260
            .|:|.:....|..: |.|::..:.|:......::..:....||.| :..::|:  :|...:....
Mouse   187 PSLAREDTYSDTCVDLGGEKMCRFLTAVQGGSFILSSVGSQLVRL-IPESSGK--IHQHVLPQGQ 248

  Fly   261 SFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAIQRWSLSNNGNTENL 325
            ..|.|.|::.:|:...::..:|.      |......:.|.:....|:...|.:|.|.::...:
Mouse   249 GMLSGIGRRVSSLFGILSPTSDL------MLASVLWDRGGSSFYTLTSSNISKWELDDSSEKQ-- 305

  Fly   326 LYEDADMLRRIREEFITNFWKFRLPADSLE--IDLHLLDFHVVKNKAYILAGAVNAAHAPQMCYA 388
             ....|:.|.::|......|......::::  :::..||.....:...|||.|.:...:|.:.|.
Mouse   306 -VHSWDVHRTLKESITDAVWGSESNYEAIKEGVNIQYLDLKQNCDGLLILAAAWHLGDSPCLVYY 369

  Fly   389 LVTGTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVV---GSSHIYLYTSKVVYPLHLTNSV 450
            .|.........:.::.| :.:.::......||.::.|.:|   .|...|||....|:    ..|.
Mouse   370 SVITVEDNGNQMSDAVT-VEVTQYNPPFQSEDLIACRLMVPNFSSQMTYLYMENAVF----VCST 429

  Fly   451 PTAE--LEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITPGDFDGTEMMNMSSCNTPDLY 513
            .|.:  |..|||.|....|.||.|..|:.:|:.|||..||||:||.:
Mouse   430 GTGKFSLPQEKIVFDTQGDGILGAGSCAGVPILFSRNSGLVSVTPRE------------------ 476

  Fly   514 APNSCNASFAVAD-HSALTNST----NNLHLFELDPDEMYNELSDEVGQLKAAFLYHMKRNSNMV 573
                 |.|....| ..:||:|.    :...:||...........|:...||||||.:.:::....
Mouse   477 -----NVSLLAEDLEESLTSSVGGRGSESMVFETTTKNETVAHEDKTKLLKAAFLQYCRKDLGRA 536

  Fly   574 KTIVDELLRNVT--AADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEEALADQEMNRHAIG 636
            :.:.|||..:.|  .:||        :||:.|..|:.||.:|.|.:||||.|::..:     |.|
Mouse   537 QIMADELFSSHTDLDSDP--------ELDKAVTQISVDLIDDYPASDPRWAESVPQE-----APG 588

  Fly   637 -SSRSMQIINQLRDKIIAFQHFITFLHSSLVWDKLNVIPCGSHSLKPTGCILADISEKIVAAMAL 700
             |:.|:.|::||.||:.|....:.|||...::.:|:..|.....:. |..:|.:.:||:.||:.|
Mouse   589 LSNTSLIILHQLEDKMKAHCLLVDFLHQVGLFRRLSSYPIRGTPMS-TRLLLCEHAEKLSAAITL 652

  Fly   701 RSIQTKLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQNVFEALADIADD---RIAAQN 762
            ::..::||.|:..||...:.....|...|||..|:|:.::|:...:.|.|.:..:.   .:|..:
Mouse   653 KNHHSRLPDLVNSAILLALNKRECEVPNSLTPADVFFREVSQVDTICECLLEHEEQVLREVALVS 717

  Fly   763 QTTISVAHFVNEINSIVLDVLGQVFKYRKQHASSFRLSHE----KLPSYENLPWTAMAGSAGVRD 823
            |....||   .::|:::.|:|.....||...:|.:  |.|    |.|.|  :||||.:|.:|:|.
Mouse   718 QEWAEVA---IDVNTVLKDMLQAATHYRLNKSSMY--SQEEVLGKEPEY--VPWTATSGPSGIRT 775

  Fly   824 TLTRLIDISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSVR---DTEKFNVLQQQFE 885
            .:.|...|.::. .:..::::|:..:.:|:..|||..||...:.|||:.   |.|:::.|:.::.
Mouse   776 AVMRQHGIILKM-VYPQADSKLRNVVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSLEVEYL 839

  Fly   886 AQRRELISVLIKDRQYEYAAKIAEKYLDFQSLVLICDETQDKERLEDYTRKYEEYDFSQFAINWH 950
            .:|.||:|.|:...||.:||.:||||.||..||.:|::|.::.||:.|..::.:.:||.|...|:
Mouse   840 QKRSELLSPLLTLGQYPWAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDFLFRWY 904

  Fly   951 LRQNRHGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETEFVARKKSM 1015
            |.:.:.|::..:.......||.|::.|..|.|:..|.:.:.|:|...|..||..||.:.|:||::
Mouse   905 LEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFAKKKTL 969

  Fly  1016 LSLAKLAAFAA--AESDLTAQVEKINADLTLVEYQSQLGHDVLESFGFDPAEQKVLKAEEIISLY 1078
            |.|:||||.|:  :|..|..::|.:......:.:|..|...:|.......:...||.|.::||||
Mouse   970 LGLSKLAALASDISEDRLQEKIEAMAEQERFLLHQETLPEQLLTERQLSLSAMPVLTAPQLISLY 1034

  Fly  1079 IAEENETASETEFRKALELLSYVEQPY-----DMRHKIWCAAIKRDNWTDYD-PNNAVHYMQKLL 1137
            |.:||..|:|.:|:|||:||.|:::..     |::.:|.|.|::||:|:..| .::.:...:..:
Mouse  1035 ICDENRRANEYDFKKALDLLEYIDEEEDVSIDDLKLEILCRALQRDDWSGSDGKDDPIEVSKDSV 1099

  Fly  1138 FYKIIEISQLMGNDSENVLPPMEDFLESVELGDLPQQKPFQYLLKLTYEY 1187
            |.||::.....|......||.:.|.|.:.:||.|.....|:::||..|||
Mouse  1100 FVKILQKLIKDGIQLSEYLPEVTDLLRAEQLGSLKSNSYFEFVLKANYEY 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	102/415 (25%)
		Nucleoporin_C	767..1122	CDD:427181	118/368 (32%)
Nup133	NP_758492.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		7/30 (23%)
		Nucleoporin_C	594..1097	CDD:427181	163/515 (32%)