Protein Alignment Nup133 and npp-15

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: NP_498724.4
• Gene: npp-15 / 176114
• WormBaseID: WBGene00003801
• Length: 1129
• Species: Caenorhabditis elegans
• Alignment Length: 1171
• Identity: 236/1171 - (20%)
• Similarity: 444/1171 - (37%)
• Gaps: 295/1171 - (25%)

  Fly    89 PVVVNEALTFAGPGAGTVTAKVTQN------GWAWVVQGRRLLIWQYKDTAKSGSPPRVGKLARR 147
            |.:|.||. .....|....::||.|      .:.||:...::.||:...::.....|
 Worm    19 PALVKEAF-LNNWHASAHRSEVTSNCASLNDRYCWVLSRNQIFIWERAKSSHRAIIP-------- 74

  Fly   148 GGGLAQCRELTLPYSDLGHKSDLISVFQ--TEGQQMASC---IAVSATGEVRYWSSIAHD----- 202
                   .:|.||.|.|......:.|:.  ..|.....|   :.||..|.:|:|:||...
 Worm    75 -------TQLPLPTSGLPRSVKCVVVYDGVHRGANKTPCPGILVVSPEGVLRHWTSIESQTYIEE 132

  Fly   203 ----GNSVDLSILTGQEFVQLLSLP---TQQGYLAVTTTCNLVFLRVGLTNGRYTLHHKT----- 255
                .|.|.|.       |:|...|   ....:|..||:..:.||     ||:.....||
 Worm   133 VLDINNEVALR-------VELTDEPIDGKSASFLLTTTSGTVYFL-----NGKGQDSAKTGALEC 185

  Fly   256 IKPATSFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAIQRWSLSNNG 320
            .|.|.....||.::.:||:.|   |..|:.|.: :......:|.:.:|..:|...:..::
 Worm   186 NKVAGREAHGFRRRLSSIMFG---GESKESTSL-ITNSFQHQSKDLLVVTVSPDVLTVYN----- 241

  Fly   321 NTENLLYEDADMLRRIREEF----ITNFWKFRLPADSLEIDLHLLDFHVVKNKAYILAGAVN--- 378
                 :|...::.....:||    |.:|::..|....|::...|:|..|.::...||.|..:
 Worm   242 -----MYTPCELWSLKTKEFFQPKIASFFEADLKRTPLKVRARLIDAAVFRDGLMILIGGTHEES 301

  Fly   379 -AAHAPQMCYALVTGTAQAERMLLESFTPLNMNKFFSAKTEEDCLSVRFVVGSSHIYLYTSKVVY 442
             :.|...:..:....|.|...::..:..|:|.::...:|.::...|
 Worm   302 QSVHMFMVWMSANWQTEQPTGVVWSARVPMNEHRALFSKIDDSIYS------------------- 347

  Fly   443 PLHLTNSVPTAELEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITPGDFDGTEMMNMSSC 507
              :||..:|....|::|.:                      ||.|::.|.|
 Worm   348 --NLTLCIPKNTAESKKAD----------------------RTDGIIIINP-------------- 374

  Fly   508 NTPDLYAPNSCNASFAVADHSALTNSTNNLHL-FEL----DPDEMYNELS----DEV--GQLKAA 561
                         .|||           :|:| |:|    .|:.:|..:|    |::  ..:.:.
 Worm   375 -------------YFAV-----------SLYLPFDLAKPKKPESLYRHVSIPPRDQLLGYAICSQ 415

  Fly   562 FLYHMKRNSNMVKTIVDELLRNVTAADPSG-APMDAYKLDRIVITIAEDLAEDIPIADPRWEEAL 625
            ::|.|...|. |.||  .||       |.| |....|..:::|:.......:|.||......|.:
 Worm   416 YVYIMMLESG-VSTI--RLL-------PRGFADSSIYTHEQVVVPSLSVGTDDWPILSELLSEMV 470

  Fly   626 AD--------QEMNR--------HAIGSSRSMQIINQLRDKIIA-----FQHFI----------- 658
            |.        |.::|        |...|...::.|.::.|:.||     |.:.|
 Worm   471 ASGLPKTPLYQSLHRAFELFAEKHMAESEEELKAIIKMPDQEIARIVSQFLYAIIDYSDAANKTD 535

  Fly   659 TFLHSSL--------------VWDKLNVIPCGSH-----SLKPTGCILADISEKIVAAMALRSIQ 704
            |.||:..              |::::...|.|..     ||:..|.:|.::||::.|:.|:.:.:
 Worm   536 TELHAKRVLTSRIMLFLKHMGVYERIISSPLGISRGGILSLRVGGTMLGEVSERVAASTAIWTWK 600

  Fly   705 T--KLPKLIEEAIDATVALWHEEPQGSLTYQDIFYVKLSRFQNVFEALADIADDRIAAQNQT-TI 766
            |  :....:.:||...|....|.....|..:|..:.:.....::....|...:..:..:.:: ..
 Worm   601 TSNETNSAVFDAIIEKVLRIPEVQDLGLKDKDALFGRCGLVHHIPVVAAQQLEKNVIGKTKSHRF 665

  Fly   767 SVAHFVNEINSIVLDVLGQVFKYRKQHASSFRLSHEK--LPSYENLPWTAMAGSAGVRDTLTRLI 829
            .|.|.|.|:.|.:           |:...|:|....|  :|.:. :.||....::..||...::|
 Worm   666 EVFHAVCELLSGI-----------KETIISWRNCRTKVAIPKFP-IWWTLETFASCYRDVAEKII 718

  Fly   830 DISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSVRDTEKFN--VLQQQFEAQRRELI 892
            : .::.||...||   :.:|...|..:.|..|        |..|::..|  |||        |:|
 Worm   719 E-ELKNGSSTDSE---RARLLMYILSIYDFYL--------SESDSQPDNDKVLQ--------EMI 763

  Fly   893 SVLIKDRQYEYAAKIAEKYLDFQSLV---LICDETQDKERLEDYTRKYEEYDFSQFAINWHLRQN 954
            : |.|...   |.::|||:.||.:||   |..|....::..|.|.:.:|:.||..:..: :|:::
 Worm   764 A-LGKPAD---AMELAEKHKDFGTLVKNYLTTDVGTRQKTFERYKKMFEKDDFEMYLCD-YLKEH 823

  Fly   955 RHGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETEFVARKKSMLSLA 1019
            ...:|..:..|::  :..::.:...|.:.:.|.|..|.:||..|..||..||:..::....|:.|
 Worm   824 GRNDVLLQQGGSR--VDAYLDNFKELRYSREIANKQFGKAALTLMSLADAETKSFSKFVEFLTRA 886

  Fly  1020 KLAAFAAAE-SDLTAQVEKINADLTLVEYQSQLGHDVLE-SFGFDPAEQKVLKAEEIISLYIA-E 1081
            ...|.::.: :|::..::........::::.::..::|: .||.|  ...::..|:::...:| :
 Worm   887 YYCACSSIDGTDVSEVLDFYKRRYPEMKHRKRIPTEILKICFGND--LDAMMSVEDMLEWNMAVQ 949

  Fly  1082 ENETASETEFRKALELLSYVEQPY----DMRHKI---WCAAIKRDNWTDYDPNNAVHYMQKLLFY 1139
            .|:.||...|.:|..||:.:...:    :::.||   |.|.:..|.|........|.  :|.:|.
 Worm   950 PNDEASVEGFARAFHLLADLLAVHPDSDELKKKIDKTWKALVDYDEWNRVRSKEDVE--KKTIFG 1012

  Fly  1140 K 1140
            |
 Worm  1013 K 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	84/435 (19%)
		Nucleoporin_C	767..1122	CDD:427181	84/371 (23%)
npp-15	NP_498724.4	Nucleoporin_C	<759..>886	CDD:427181	36/141 (26%)