Protein Alignment Nup133 and nup133

DIOPT Version :10

• Sequence 1: NP_651080.2
• Gene: Nup133 / 42680
• FlyBaseID: FBgn0039004
• Length: 1200
• Species: Drosophila melanogaster
• Sequence 2: XP_002932582.1
• Gene: nup133 / 100494693
• XenbaseID: XB-GENE-999348
• Length: 1142
• Species: Xenopus tropicalis
• Alignment Length: 1215
• Identity: 340/1215 - (27%)
• Similarity: 594/1215 - (48%)
• Gaps: 147/1215 - (12%)

  Fly    19 GARRYSMPAASADSTRKSIFGGSASCAQMSGSLKRTALTNSRLSLSVRSTQSIAGIRSDYNSVES 83
            |.|:...|..||.|:..:::.........||:..    |.||:.|...:::::     :|| |:.
 Frog    23 GGRKGLGPGVSASSSPSALYSPVGRRVSSSGARS----TPSRVYLHPAASETV-----NYN-VQL 77

  Fly    84 FGCPLPVVVNEALTFAGPGAGTVTAKVTQNGWAWVVQGRRLLIWQ--YKDTAKSGSPPRVGKLAR 146
            ||..|||.|.|||:.:|... .:.|::.:.||||:....||:||:  :..:||
 Frog    78 FGSSLPVKVMEALSNSGVDE-PLAARIHEGGWAWLACKDRLIIWKISHSTSAK------------ 129

  Fly   147 RGGGLAQCRELTLPYSDLGHKSDLISVFQTEGQ----QMASCIAVSATGEVRYWSSIAHDGNSVD 207
                |..|:||.||.||....:||..:....|.    |..:.:|.:..|..|||.:|.|:.|.::
 Frog   130 ----LMVCKELPLPLSDSEWSADLADICAHTGDSAAGQAVALMAATPEGSARYWPNILHESNYIE 190

  Fly   208 ------------LSILTGQEFVQLLSLPTQQGYLAVTTTCNLVFLRVGLT---NGRYTLHHKTIK 257
                        ::.:.|..|:    |.:::.:|            |.||   :|:  ::.:.:.
 Frog   191 SYADFGSSLCAFVTAVKGNSFI----LSSEKNHL------------VRLTPDASGK--INQRILP 237

  Fly   258 PATSFLGGFGKKFASILIGMNTGADKDQTLVGMCCESNLESGETIVAVLSDRAIQRWSLSNNGNT 322
            .....|.|.|:: .|.|.|:.:.| .:.||    |....:.|:... .|:|.:|.:|.|.:...:
 Frog   238 QGQGMLSGIGRR-VSTLFGILSPA-VESTL----CSVLWDKGDCFY-TLTDSSINKWDLDDASES 295

  Fly   323 ENLLYEDADMLRRIREEFITNFWKFRLPADSLE--IDLHLLDFHVVKNKAYILAGAVNAAHAP-Q 384
            ..|.:   ||.|.:||......|......|.::  |::..|..:...:...|||.|.:....| |
 Frog   296 HVLTW---DMTRVLRENISDAIWGSESNYDDIKNGINIDYLSLNQNCDGLVILAAAWHPGDNPCQ 357

  Fly   385 MCYALVT----GTAQAERMLLE--SFTPLNMNKFFSAKTEEDCLSVRFVVGSSHIYLYTSKVVYP 443
            :.|.|||    |...::.:.:|  .|.|:     |.::..:.|..|.....|...||||..:|:.
 Frog   358 IYYTLVTVKDEGYNISDEITVEVTQFNPV-----FQSRDMQLCQLVIPNFSSQACYLYTQDMVFA 417

  Fly   444 LHLTNSVPTAELEAEKIEFHQHDDRILSAVICSQLPLFFSRTHGLVSITPGDFDGTEMMNMSSCN 508
              .:.....:.|..|||.|....|.|:.|..|...|:||.|..|::::...:.......:|..
 Frog   418 --CSTGTGRSTLPQEKIPFEAQGDNIIGAGSCEGWPVFFIRKSGMLTVVARETASVLPEHMEE-- 478

  Fly   509 TPDLYAPNSCNASFAVADHSALTNSTNNLHLFELDPDEMYNELSDEVGQLKAAFLYHMKRNSNMV 573
              .|.:.:..::..||.|      ||:.       ||::.::  |:...||||||...:::....
 Frog   479 --SLLSVSKSSSQAAVKD------STSR-------PDQIAHD--DKTKLLKAAFLRCCRKDILGA 526

  Fly   574 KTIVDELLRNVTAADPSGAPMDAYKLDRIVITIAEDLAEDIPIADPRWEEALADQEMNRHAIG-S 637
            :::||.|.     :|....|.|  :||:.|..|:.||.:|.|.:||||.|::.::     |.| |
 Frog   527 QSMVDSLF-----SDSDMGPDD--ELDQAVNQISVDLIDDYPASDPRWAESVPEE-----AAGFS 579

  Fly   638 SRSMQIINQLRDKIIAFQHFITFLHSSLVWDKLNVIPCGSHSL-KPTGCILADISEKIVAAMALR 701
            :.|:.:::||.||:.|...|:.|||...::.:|:.  |.:..: ..|..:|.:.:||:.||:.|:
 Frog   580 NTSLILLHQLEDKMKAHSFFVDFLHQVGLFSRLST--CQAKGMFVATRLLLCEHAEKLSAAIVLK 642

  Fly   702 SIQTKLPKLIEEAIDATVAL---WHEEPQGSLTYQDIFYVKLSRFQNVFEALADIADDRIAAQNQ 763
            :...|||.|:..||.  :||   ....|| :||..|:::.::|:...:||.|.|..:..:.:.:.
 Frog   643 NHHAKLPALVNSAIQ--LALDKRMCSIPQ-NLTAADVYFREVSQMDIIFECLVDKEEADLESTSM 704

  Fly   764 TTISVAHFVNEINSIVLDVLGQVFKYRKQHASSFRLSHEKLPSYENLPWTAMAGSAGVRDTLTRL 828
            .::..|:.|..||:|:.|:|....:||:...|.:: :...:...|.:||||.:|.||:|..:||.
 Frog   705 DSVEWANIVVNINTILKDMLHAACQYRQSKNSLYK-NESGMQEPEYVPWTASSGIAGIRSVVTRQ 768

  Fly   829 IDISVRYGSHCVSETELKQQLYQQIFELIDLVLDGRKTYLKSV---RDTEKFNVLQQQFEAQRRE 890
            ..:.::.  :..:::.|:..|.:|:..|::.:||.....||||   .:.|:::||:.::..:|.|
 Frog   769 HGVILKI--YPQADSSLRTILIEQLAALLNYLLDDYVIQLKSVDKRTNQERYSVLEMEYAQKRSE 831

  Fly   891 LISVLIKDRQYEYAAKIAEKYLDFQSLVLICDETQDKERLEDYTRKYEEYDFSQFAINWHLRQNR 955
            |::.|:...||.:|:.:||||.||..||.||:.|.::.||:.|...:.:.:||.|...|:|.:.:
 Frog   832 LLAPLLSLGQYAWASNLAEKYCDFDILVQICEMTDNQSRLQRYMTLFSDQNFSDFLFRWYLEKGK 896

  Fly   956 HGEVFERFKGNQTALAQFMRDHPSLGWIQLIFNGDFERAAKVLYELAQCETEFVARKKSMLSLAK 1020
            .|::..:.......||.|::.|..|.|:..:.:.:||:|.:.|:.||..||.:..:||::|.|:|
 Frog   897 RGKLLSQPASQHGQLAVFLQAHEHLSWLHEVNSQEFEKAHRTLHTLANMETRYFCKKKTLLGLSK 961

  Fly  1021 LAAFAA--AESDLTAQVEKINADLTLVEYQSQLGHDVLESFGFDPAEQKVLKAEEIISLYIAEEN 1083
            |||.|:  .|..|..:||:|......:.:|..|...:||....|.....||...|:|.|||.|||
 Frog   962 LAALASDFQEDILQEKVEEIAEQEHFLLHQETLPKQLLEEKQLDLNTMPVLSPIELIQLYICEEN 1026

  Fly  1084 ETASETEFRKALELLSYVEQP-----YDMRHKIWCAAIKRDNWTDYD-PNNAVHYMQKLLFYKII 1142
            :.|:|.:|:|||:||.|:...     .:::.:|.|.|:|||.|...| .::.:...::.:|.|::
 Frog  1027 KRANENDFKKALDLLEYIGDDSEVDIEELKLEILCKAVKRDEWCATDGKDDPIEATKESIFVKVL 1091

  Fly  1143 EISQLMGNDSENVLPPMEDFLESVELGDLPQQKPFQYLLKLTYEY 1187
            :.....|.:.::.||..|..|:|.||..|.....|::.||..|||
 Frog  1092 QNLLNKGIELKSYLPEAETLLQSDELSSLKTNSYFEFSLKANYEY 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup133	NP_651080.2	Nucleoporin_N	87..489	CDD:400932	110/431 (26%)
		Nucleoporin_C	767..1122	CDD:427181	119/364 (33%)
nup133	XP_002932582.1	Nucleoporin_N	80..442	CDD:400932	102/413 (25%)
		Nucleoporin_C	624..1077	CDD:427181	146/458 (32%)