DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wfs1 and Wfs1

DIOPT Version :9

Sequence 1:	NP_651079.2	Gene:	wfs1 / 42679	FlyBaseID:	FBgn0039003	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_114011.1	Gene:	Wfs1 / 83725	RGDID:	68954	Length:	890	Species:	Rattus norvegicus

Alignment Length:	865	Identity:	208/865 - (24%)
Similarity:	357/865 - (41%)	Gaps:	194/865 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AEEGCPQMQYDLAK---ELLDNSIVEPNLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGS 95
            |:.|.|:.|.::.|   .|.:::..|.|      |..||.||:.||..|..:||||||:|..|..
  Rat    96 AKAGDPKAQTEVGKHYLRLANDADEELN------SCSAVAWLILAAKQGRREAVKLLRRCLADRK 154

  Fly    96 GITAENTDEVRRCLAMTPGERAARKAA-----------------RELFACLSNGNEH-------I 136
            |||:||..||::..:.|..|||.||||                 .||...:...||.       .
  Rat   155 GITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGP 219

  Fly   137 TPKQLERKMRRIYNLQRKRRR--------------------------RDDDRSSSSSEGEQEPEC 175
            .||.|:::.|.:..|.....:                          :|:|      |.|.|...
  Rat   220 VPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPNNLFLQDED------EDEDELSG 278

  Fly   176 EPLEDVPTIDLANVERRRLI---------TEAHLVSAASNYSAGQMPSVNDALTLSVPDPRSLDH 231
            :..||:|.       |::::         .:.:|:..||......:.::
  Rat   279 KSPEDLPL-------RQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTI---------------- 320

  Fly   232 VPCFYRMIFHPLIFFTLFYHRLLNLIVSIPNVIPLSVRCSVLVAISWWSSRHMLPLVSYYLSLGI 296
            ||..:   .:.||||.:    :.||.:..                    ....:|||.:|||...
  Rat   321 VPTHH---INALIFFFI----ISNLTIDF--------------------FAFFIPLVVFYLSFVS 358

  Fly   297 MIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYP 361
            |:..|.|:.:..:.:.:||..:.|.|.: :.|::.:.||..|..|:::||::|..:.:..:..:|
  Rat   359 MVICTLKVFQDSKAWENFRTLTDLLLRF-EPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFP 422

  Fly   362 LVTDAWLPHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMDEVVSTRWR 426
            |.:...:|.|||.::|...| :|..:|:.:|:.......::...|..:|:..|     .:...|.
  Rat   423 LASKDCIPCSELAVVSAFFT-VTSYMSLSSSAEPYTRRALVTEVAAGLLSLLP-----TMPVDWP 481

  Fly   427 FLDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSWLQVC 491
            ||.....||.:..||:.|...::....||:::..|...||:...:.|.|.:|:|:.|...|.::.
  Rat   482 FLKALGQTFFTVPIGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELS 546

  Fly   492 IATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSLGLASEQLRWGSTALACGLVV 556
            :.....||..|::||::|     .||.||.:     |:.||    |||           ..|.|.
  Rat   547 VVILLQSTGLGLVRASIG-----YFLFLFAL-----PILVA----GLA-----------LMGTVQ 586

  Fly   557 VLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAMPRAGLHSL-------- 613
            .....|:|:      :|.:.:.|.|.:..||...:..::|.......::.|:.:..|
  Rat   587 FARWFLSLD------LTKIMVTTVICSVPLLFRWWTKANFSVVGMVKSLTRSSIVKLILVWLTAI 645

  Fly   614 ----------SE-----TNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVE 663
                      ||     .:||.|.::..||.....::.|..:.|:.||.|.|..|.|.|....|.
  Rat   646 LLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVR 710

  Fly   664 ISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDAQCEEWRSVFKTFNAQSGSCTL 728
            ::.:.|..|..| |.||.:||..:|||:||   .:..|.....:..||  .:.:........|.:
  Rat   711 VTEIDNSAESAI-NMLPFFLGDWMRCLYGE---AYPSCSSGNTSTAEE--ELCRLKQLAKHPCHI 769

  Fly   729 QRWNRYEYELLVKV--GTKRSGRLLGRSTTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRL 791
            ::::||::|:.|.:  ||..:........|.|::|||..:|.:....|.:|.::.|..|| ..||
  Rat   770 KKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTIL-EGRL 833

  Fly   792 LADNVQVKLKTIECVECRSR 811
            .:.....:||.|.|:.|.::
  Rat   834 GSKWPVFELKAISCLNCMTQ 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..154	CDD:223861	48/146 (33%)
Wfs1	NP_114011.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341363
Domainoid	1	1.000	201	1.000	Domainoid score	I2909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4380
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3685
OMA	1	1.010	-	-		QHG46084
OrthoDB	1	1.010	-	-		D409213at33208
OrthoFinder	1	1.000	-	-		FOG0006904
OrthoInspector	1	1.000	-	-		oto95912
orthoMCL	1	0.900	-	-		OOG6_108955
Panther	1	1.100	-	-	LDO	PTHR13098
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910