DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wfs1 and WFS1

DIOPT Version :9

Sequence 1:	NP_651079.2	Gene:	wfs1 / 42679	FlyBaseID:	FBgn0039003	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	XP_016864075.1	Gene:	WFS1 / 7466	HGNCID:	12762	Length:	893	Species:	Homo sapiens

Alignment Length:	861	Identity:	215/861 - (24%)
Similarity:	365/861 - (42%)	Gaps:	185/861 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AEEGCPQMQYDLAK---ELLDNSIVEPNLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGS 95
            |:.|.|:.|.::.|   :|..::..|.|      |..||:|||.||..|..:||||||:|..|..
Human    98 AKAGDPKAQTEVGKHYLQLAGDTDEELN------SCTAVDWLVLAAKQGRREAVKLLRRCLADRR 156

  Fly    96 GITAENTDEVRRCLAMTPGERAARKAA-----------------RELFACLSNGNEH-------I 136
            |||:||..|||:..:.|..|||.||||                 .||...:...|||       .
Human   157 GITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGP 221

  Fly   137 TPKQLERKMRRIYNLQRKRRRRDDDRSSSSSEGEQEPECEPLEDVPTIDLANVERRRLITEAHLV 201
            .||.|: |.||:  |:|                                |.:.|.:..|.....|
Human   222 VPKSLQ-KQRRM--LER--------------------------------LVSSESKNYIALDDFV 251

  Fly   202 SAASNYSAGQMPSVNDALTLSVPDP--------RSLDHVPCFYRMIFHPLIFFTLFYHRLLNLIV 258
            .....|:.|.:||     :|.:.|.        :|.:.:|...:::.:||       |.::.:
Human   252 EITKKYAKGVIPS-----SLFLQDDEDDDELAGKSPEDLPLRLKVVKYPL-------HAIMEI-- 302

  Fly   259 SIPNVIPLSVRCSVLVAISWWS----SRHM--------------------LPLVSYYLSLGIMIW 299
             ...:|.::.|    ..:.|.|    :.|:                    :|||.:|||...|:.
Human   303 -KEYLIDMASR----AGMHWLSTIIPTHHINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVI 362

  Fly   300 ATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYPLVT 364
            .|.|:.:..:.:.:||..:.|.|.: :.|::.:.||..|..|:::||.:|..:....:..:|:.:
Human   363 CTLKVFQDSKAWENFRTLTDLLLRF-EPNLDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIAS 426

  Fly   365 DAWLPHSELTIISGALTFITMCVSMYASSHQLP--DWLVIVSFAVNVLAKYPYEMDEVVSTRWRF 427
            ...:|.|||.:|:|   |.|:...:..|:|..|  ...:.......:|:..|     .:...|.:
Human   427 KDCIPCSELAVITG---FFTVTSYLSLSTHAEPYTRRALATEVTAGLLSLLP-----SMPLNWPY 483

  Fly   428 LDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSWLQVCI 492
            |.:...||.:..:|:.:...::....||:::..|...||:...:.|.|.:|:|:.|...|.::.:
Human   484 LKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSV 548

  Fly   493 ATSQSSTVFGVMRAALG----------------LAGIVLFLPLFGIVALL-VPVFVAIDSLGLAS 540
            .....||..|::||::|                |.|::.|...|..:.|. :.|.||:.|:.|.
Human   549 VILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLL- 612

  Fly   541 EQLRWGSTALACGLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAM 605
              |||.:.|    ...|:..:.:|.|:     :|::||....||.:|...:.....:....:|
Human   613 --LRWWTKA----SFSVVGMVKSLTRS-----SMVKLILVWLTAIVLFCWFYVYRSEGMKVYN-- 664

  Fly   606 PRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNF 670
                       :||.|.::.|||.....::.|..:.|:.||.|.|..|.|.|....|.::.:.|.
Human   665 -----------STLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNS 718

  Fly   671 LEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDAQCEEWRSVFKTFNAQSGSCTLQRWNRYE 735
            .|..| |.||.::|..:|||:||   .:..|.|...:..||.....|..  ....|.:::::||:
Human   719 AESAI-NMLPFFIGDWMRCLYGE---AYPACSPGNTSTAEEELCRLKLL--AKHPCHIKKFDRYK 777

  Fly   736 YELLVKVGTKRSGRLLGRS-----TTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADN 795
            :|:.|.:... ||....||     .|.|::|||..:|.:....|.:|.::.|..|| ..||.:..
Human   778 FEITVGMPFS-SGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTIL-EGRLGSKW 840

  Fly   796 VQVKLKTIECVECRSR 811
            ...:||.|.|:.|.::
Human   841 PVFELKAISCLNCMAQ 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..154	CDD:223861	53/146 (36%)
WFS1	XP_016864075.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147562
Domainoid	1	1.000	202	1.000	Domainoid score	I2985
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4380
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3761
Isobase	1	0.950	-	0	Normalized mean entropy	S8020
OMA	1	1.010	-	-		QHG46084
OrthoDB	1	1.010	-	-		D409213at33208
OrthoFinder	1	1.000	-	-		FOG0006904
OrthoInspector	1	1.000	-	-		oto88778
orthoMCL	1	0.900	-	-		OOG6_108955
Panther	1	1.100	-	-	LDO	PTHR13098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5369
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890