Protein Alignment wfs1 and wfs1a

DIOPT Version :10

• Sequence 1: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_695252.6
• Gene: wfs1a / 566876
• ZFINID: ZDB-GENE-080225-11
• Length: 1061
• Species: Danio rerio
• Alignment Length: 989
• Identity: 224/989 - (22%)
• Similarity: 408/989 - (41%)
• Gaps: 215/989 - (21%)

  Fly     9 PTGVTKRRRWNLEDRASLNKLKHHIA-------------------EEGCPQMQYDLA-KELLDNS 53
            |.|:|...:....|...|.:.:..:|                   .|.|..|:.||. :|||..:
Zfish   135 PEGLTSTTKTPASDSGKLPRQRSFLAAAQKVMMQEKTRKAEEQAKAEECDDMEDDLPFEELLKKA 199

  Fly    54 IV-EP-----------NLAKGNQSQK----AVNWLVSAAHNGHEDAVKLLRQCYNDGSGITAENT 102
            .. :|           .||:...::|    ||.||:.||..|..||.|||::|:....||||||.
Zfish   200 EAGDPRAQSRLGRYYLKLAEEKDAEKNNLTAVEWLMKAAKQGRRDAAKLLQKCWIQKKGITAENA 264

  Fly   103 DEVRRCLAMTPGERAARKAARELFACLS-NGNEHITPKQLERKMRRIY-------------NLQR 153
            .|||...:.:..|:|.|:||..::..|: :..:.:...::...:.::.             ::|.
Zfish   265 QEVRCLSSESKFEQAVRRAAMTMYWKLNPDRKKKVAMSEMLENVSQVNTVPGEASVCGVAPSIQT 329

  Fly   154 KRRRRDDDRSSSSSEGEQEPE---------CEPLEDVPTIDLANV-------------------E 190
            :|:..:...|:.||....:.|         .|.:...||:..:.|                   |
Zfish   330 QRKILETMVSNESSSKYVDVEDFVEMTKKFTEGISRTPTLSPSGVYANEEEGILHKSDVARFDKE 394

  Fly   191 RRRLITEAHLVSAASNY---SAGQMPSV--NDALTLSVPDPRSLDHVPCFYRMIFHPLIFFTLFY 250
            :..:....|.....|::   |:|.|.:.  :||:.      |:|| :...:..:.:||
Zfish   395 KNEMAPVTHKRQRKSSWGMRSSGLMLTTRRSDAMR------RALD-IKAHFLGLQYPL------- 445

  Fly   251 HRLLNLIVSIPNVIPLSVRCSVLVAISWWS----SRHM--------------------LPLVSYY 291
            |.::::   ..::|..:.|..|    .|.|    ::|:                    :||:.:|
Zfish   446 HAIIDM---KEHLIDWASRAGV----QWLSTIIPTQHVNALIFFFIISNLTIDLFAFAIPLLIFY 503

  Fly   292 LSLGIMIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICN 356
            ||...|...|.::.::.:.:.:||.::.| |::.:.:::.:.||:.|..||::.||||..:....
Zfish   504 LSFISMAICTLRVFQSSKGWENFRAFTAL-LTHFEPSLDVEQAENNFGWNNLEQYLYFMISVFFV 567

  Fly   357 LIVYPLVTDAWLPHSELTIIS---GALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMD 418
            :..:|:....|:|.|||:.::   .||:::::..|..|.:.:.. ::.:.|....:.::.|.:|
Zfish   568 IFTFPVADKGWIPCSELSTVAIFFTALSYMSLSPSAAAYARKAL-FIEVASSLCALTSRLPKDM- 630

  Fly   419 EVVSTRWRFLDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCV 483
              |:.|     :....|::..:|..:...|:....||:::..|...||:...:.|.|.||:|:.|
Zfish   631 --VTAR-----MLGQIFTTIPLGESLVLELSVPCVLYIYLFYLFFSMARMRGFRGTYCFLVPYLV 688

  Fly   484 TLSWLQVCIATSQSSTVFGVMRAALGLAGIVLFLP--LFGIVALLVPVFVAIDSLGLASEQLRWG 546
            ...|.:..:...::||..|::|..:.....:..||  :.|::|||:   :.:....|..|..:..
Zfish   689 CFVWCEFSVVLLRNSTTIGLIRTCVAYFLFLFALPVLIMGLIALLL---IQLIKWFLELELTKML 750

  Fly   547 STALACGLVVVLS-------CILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNA 604
            .|...|.:.|.|.       .||.:.|:......:..::..|||..||...|:         :||
Zfish   751 VTLAVCAVPVTLRLWTRFSLSILNVFRSITHRGPVKLILLCITTVILLCGVYV---------YNA 806

  Fly   605 MPRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSN 669
               .||...:  :||.|:.:..||.....::....:.||.||.|.|..|.|.|....|.::...|
Zfish   807 ---EGLKVYN--STLTWEEYGTLCGPQAWKERGMAQTQLSCSHLEGHRVTWTGIFRYVRVAEKEN 866

  Fly   670 FLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDA----------------------QCEEW 712
            ..:..| |.|||::|..||||:||   .:.||:|..:.                      |.||.
Zfish   867 GAQSVI-NMLPVFMGDWLRCLYGE---VYPKCEPLNNTFPIVNVTQVTTGTVNTTILILRQEEEE 927

  Fly   713 RSVFKTFNAQSGSCTLQRWNRYEYELLVKVGTKRSGRLLGRSTTTDVILRAHHDFGNFTRLLSEG 777
            ....|.:  .:..|.::|::.|.:|  |.||....|.....:...|::|.|.|:|......|:.|
Zfish   928 LCRIKAY--ATHQCHVKRFDSYRFE--VTVGMPVDGVTKVDNPAGDILLMASHEFRQVLLNLNPG 988

  Fly   778 DVVLFYGILH---NSRLLADNVQVKLKTIECVECRSR---DLGTASIERVVAASPMDARLQDLMR 836
            .:|.|...|.   .|:|.|    .:||.|.|:.|.|.   :.....|||....|        :::
Zfish   989 SMVEFSTKLEGKLGSKLPA----FELKAIHCLNCSSNLVPEGRQVKIERNWRKS--------MLK 1041

  Fly   837 GIKYLLNALLNPLI 850
            .||:..:....|.:
Zfish  1042 AIKFAFDFFFAPFL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..121	CDD:440553	38/122 (31%)
		WSLR	79..117	CDD:466262	17/37 (46%)
		WEF-hand	118..208	CDD:466231	17/134 (13%)
		WC-rich	621..730	CDD:466275	34/130 (26%)
		WCOB	731..853	CDD:437745	32/126 (25%)
wfs1a	XP_695252.6	None