Protein Alignment wfs1 and wfs1b

DIOPT Version :10

• Sequence 1: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_684510.3
• Gene: wfs1b / 556580
• ZFINID: ZDB-GENE-050809-19
• Length: 895
• Species: Danio rerio
• Alignment Length: 930
• Identity: 235/930 - (25%)
• Similarity: 385/930 - (41%)
• Gaps: 212/930 - (22%)

  Fly     9 PTGVTKRRRWNLEDRASLNKLKHHIAEEGCPQMQYDLAKELLDNSIVEPNLAKGNQSQ----KAV 69
            |.|.:|       :..|::.||.. |:.|..:.|.::.:..|       .||:....:    .||
Zfish    77 PQGESK-------EELSIDDLKQR-AKNGDAKAQTEIGRYYL-------RLAEQEDEEVNAVTAV 126

  Fly    70 NWLVSAAHNGHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERAARKAARELFACLS-NGN 133
            .||:.||.||.:||||||::|.:|..||||||.:||......:..:|:.||||..::..|: :..
Zfish   127 TWLLQAAKNGRKDAVKLLQRCLHDRRGITAENREEVCSLACESRFQRSVRKAALLMYWKLNPDRK 191

  Fly   134 EHITPKQLERKMRRIYNLQRKRRRRDDDRSSSSSEGEQEPECEPLEDVPTI--DLANVERRRLIT 196
            ::||..:|...:.::          :.|.:|.|      |...|::....|  .|.:.:....|.
Zfish   192 KNITASELLENVSQL----------NTDGASRS------PLSSPIQKQRKILESLVSRDETDCIG 240

  Fly   197 EAHLVSAASNYSAGQMPSV-------NDALTLSVPDPRSLDHVPCFYRMIFHPLIFFTLFYHRLL 254
            ....|.....|:.|..||:       :|.....|..|   |.:|...:::..||       |.:|
Zfish   241 VEEFVENTKQYAEGISPSMEGVAGDDDDDDEEPVKHP---DELPLHQKVLKFPL-------HAVL 295

  Fly   255 NL------------IVSIPNVIP---------------LSVRCSVLVAISWWSSRHMLPLVSYYL 292
            .:            :..|..:||               |::...|||          :||:.:||
Zfish   296 EVKEVLIDWASRAGMQWISALIPTHHVNTLIFFFIISNLTLEFFVLV----------IPLIIFYL 350

  Fly   293 SLGIMIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNL 357
            |...|:..|.::.:..:.:.:||..: :.||:.:..|:.:.||..|..|:::|||||..:.:..:
Zfish   351 SFVSMVICTLRVFQNSKAWENFRALT-VMLSHFEPGIDLEQAESNFTWNHLEPYLYFLLSTLFLI 414

  Fly   358 IVYPLVTDAWLPHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMDEVVS 422
            ..:|:...:|||.|||.:::   .|.|  ||.|.|..  |.......||:         :.:|.|
Zfish   415 FSFPVADKSWLPCSELAMVA---VFFT--VSSYLSLR--PTAQQHAKFAL---------LSQVAS 463

  Fly   423 TRWRFLDLRVPTFSSFVIGNGIEFCLN------------CRTALYLFIPVLLIMMAKRSRWHGVY 475
            ..:.|::..:..:...:|| |..|.:.            |  .|||::..|...||......|.|
Zfish   464 AIFTFINRLLGGWVGRIIG-GAWFSMRLGDWLVMHVGVPC--VLYLYLLFLCTRMATAGGARGTY 525

  Fly   476 TFLIPHCVTLSWLQVCIATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSLGLAS 540
            ..|:|:.|...|.:||:...|.|||.|:||:   :.|.:||             |.|:..|.|
Zfish   526 CVLLPNLVCFIWCEVCVTLLQESTVLGLMRS---VVGYLLF-------------FFALPVLSL-- 572

  Fly   541 EQLRWGSTALACGLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAM 605
                    |||..::|.|          .::...|:|...|.|.|:.|||.:   .:...||:..
Zfish   573 --------ALAAVMLVQL----------VQWFLALELTKMIVTVCICVLPVL---LRWWTRFSVS 616

  Fly   606 PRAGLHSLSET-------------------------------NTLPWDRFHALCAQPVHEQPNKI 639
            |.|.|.||..:                               :||.|..:..||.....::.|..
Zfish   617 PLAVLRSLRRSSVVKLILVWISALVLFSWFYVYRSEGMKVYNSTLTWQEYSDLCGPRAWKERNMA 681

  Fly   640 KAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPK 704
            .||:.||.|.|..|.|||....|.::.:.|..: .:.|.|||.:...:|||:||   ::..||..
Zfish   682 HAQIICSHLEGHRVTWEGRFKYVRVTEIENGAQ-AVVNLLPVLIADWVRCLYGE---EYPACDEN 742

  Fly   705 LDAQCEEWRSVFKTFNAQSGSCTLQRWNRYEYELLVKVGTKRSGRLLGR---STTTDVILRAHHD 766
            .....|....: ||.  ....|.::|::.|::|  |.:|..:.||...:   ..|.|::|||.::
Zfish   743 QTGPAEPLCQL-KTL--AKHKCHVKRFDHYKFE--VTMGMPQKGRNGAQDFDDGTKDIVLRASNE 802

  Fly   767 FGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRSRDLGTASIERVVAASPMDARL 831
            |.....:||.|.||.|..:| ..||.:.....:||.:.|..|.|   ....|.|.|... .|.|:
Zfish   803 FRRVLLVLSSGSVVEFSTVL-EGRLGSKWPVFELKALNCKTCAS---PLIPIRRQVKIE-QDWRV 862

  Fly   832 QDLMRGIKYLLNALLNPLIT 851
             :....:.:..|.:.:||::
Zfish   863 -NARNALAFAFNFVFHPLLS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..121	CDD:440553	32/90 (36%)
		WSLR	79..117	CDD:466262	17/37 (46%)
		WEF-hand	118..208	CDD:466231	17/92 (18%)
		WC-rich	621..730	CDD:466275	31/108 (29%)
		WCOB	731..853	CDD:437745	34/124 (27%)
wfs1b	XP_684510.3	None