Protein Alignment wfs1 and wfs1b

DIOPT Version :9

• Sequence 1: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_684510.2
• Gene: wfs1b / 556580
• ZFINID: ZDB-GENE-050809-19
• Length: 895
• Species: Danio rerio
• Alignment Length: 919
• Identity: 232/919 - (25%)
• Similarity: 382/919 - (41%)
• Gaps: 205/919 - (22%)

  Fly    20 LEDRASLNKLKHHIAEEGCPQMQYDLAKELLDNSIVEPNLAKGNQSQ----KAVNWLVSAAHNGH 80
            :::..|::.||.. |:.|..:.|.::.:..|       .||:....:    .||.||:.||.||.
Zfish    81 IKEELSIDDLKQR-AKNGDAKAQTEIGRYYL-------RLAEQEDEEVNAVTAVTWLLQAAKNGR 137

  Fly    81 EDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERAARKAARELFACLS-NGNEHITPKQLERK 144
            :||||||::|.:|..||||||.:||......:..:|:.||||..::..|: ...::||..:|...
Zfish   138 KDAVKLLQRCLHDRRGITAENREEVCSLACESRFQRSVRKAALLMYWKLNPERKKNITASELLEN 202

  Fly   145 MRRIYNLQRKRRRRDDDRSSSSSEGEQEPECEPLEDVPTI--DLANVERRRLITEAHLVSAASNY 207
            :.::          :.|.:|.|      |...|::....|  .|.:.:....|.....|.....|
Zfish   203 VSQL----------NTDGASRS------PLSSPIQKQRKILESLVSRDETDCIGVEEFVENTKQY 251

  Fly   208 SAGQMPSV-------NDALTLSVPDPRSLDHVPCFYRMIFHPLIFFTLFYHRLLNL--------- 256
            :.|..||:       :|.....|..|   |.:|...:::..||       |.:|.:
Zfish   252 AEGISPSMEGVAGDDDDDDEEPVKHP---DELPLHQKVLKFPL-------HAVLEVKEVLIDWAS 306

  Fly   257 ---IVSIPNVIP---------------LSVRCSVLVAISWWSSRHMLPLVSYYLSLGIMIWATCK 303
               :..|..:||               |::...|||          :||:.:|||...|:..|.:
Zfish   307 RAGMQWISALIPTHHVNTLIFFFIISNLTLEFFVLV----------IPLIIFYLSFVSMVICTLR 361

  Fly   304 MLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYPLVTDAWL 368
            :.:..:.:.:||..: :.||:.:..|:.:.||..|..|:::|||||..:.:..:..:|:...:||
Zfish   362 VFQNSKAWENFRALT-VMLSHFEPGIDLEQAESNFTWNHLEPYLYFLLSTLFLIFSFPVADKSWL 425

  Fly   369 PHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMDEVVSTRWRFLDLRVP 433
            |.|||.:::   .|.|  ||.|.|..  |.......||:         :.:|.|..:.|::..:.
Zfish   426 PCSELAMVA---VFFT--VSSYLSLR--PSAQQHAKFAL---------LSQVASAIFTFINRLLG 474

  Fly   434 TFSSFVIGNGIEFCLN------------CRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLS 486
            .:...:|| |..|.:.            |  .|||::..|...||......|.|..|:|:.|...
Zfish   475 GWVGRIIG-GAWFSMRLGDWLVMHVGVPC--VLYLYLLFLCTRMATAGGARGTYCVLLPNLVCFI 536

  Fly   487 WLQVCIATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSLGLASEQLRWGSTALA 551
            |.:||:...|.|||.|:||:   :.|.:||             |.|:..|.|          |||
Zfish   537 WCEVCVTLLQESTVLGLMRS---VVGYLLF-------------FFALPVLSL----------ALA 575

  Fly   552 CGLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFKDTPRFNAMPRAGLHSLSET 616
            ..::|.|          .::...|:|...|.|.|:.|||.:   .:...||:..|.|.|.||..:
Zfish   576 AVMLVQL----------VQWFLALELTKMIVTVCICVLPVL---LRWWTRFSVSPLAVLRSLRRS 627

  Fly   617 -------------------------------NTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNG 650
                                           :||.|..:..||.....::.|...||:.||.|.|
Zfish   628 SVVKLILVWISALVLFSWFYVYRSEGMKVYNSTLTWQEYSDLCGPRAWKERNMAHAQIICSHLEG 692

  Fly   651 MPVIWEGSVTKVEISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDAQCEEWRSV 715
            ..|.|||....|.::.:.|..: .:.|.|||.:...:|||:||   ::..||.......|....:
Zfish   693 HRVTWEGRFKYVRVTEIENGAQ-AVVNLLPVLIADWVRCLYGE---EYPACDENQTGPAEPLCQL 753

  Fly   716 FKTFNAQSGSCTLQRWNRYEYELLVKVGTKRSGRLLGR---STTTDVILRAHHDFGNFTRLLSEG 777
             ||.  ....|.::|::.|::|  |.:|..:.||...:   ..|.|::|||.::|.....:||.|
Zfish   754 -KTL--AKHKCHVKRFDHYKFE--VTMGMPQKGRNGAQDFDDGTKDIVLRASNEFRRVLLVLSSG 813

  Fly   778 DVVLFYGILHNSRLLADNVQVKLKTIECVECRSRDLGTASIERVVAASPMDARLQDLMRGIKYLL 842
            .||.|..:| ..||.:.....:||.:.|..|.|   ....|.|.|... .|.|: :....:.:..
Zfish   814 SVVEFSTVL-EGRLGSKWPVFELKALNCKTCAS---PLIPIRRQVKIE-QDWRV-NARNALAFAF 872

  Fly   843 NALLNPLIT 851
            |.:.:||::
Zfish   873 NFVFHPLLS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..154	CDD:223861	39/124 (31%)
wfs1b	XP_684510.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581345
Domainoid	1	1.000	198	1.000	Domainoid score	I3039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4380
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3770
OMA	1	1.010	-	-		QHG46084
OrthoDB	1	1.010	-	-		D409213at33208
OrthoFinder	1	1.000	-	-		FOG0006904
OrthoInspector	1	1.000	-	-		otm24743
orthoMCL	1	0.900	-	-		OOG6_108955
Panther	1	1.100	-	-	LDO	PTHR13098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5369
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940