DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wfs1 and Wfs1

DIOPT Version :9

Sequence 1:	NP_651079.2	Gene:	wfs1 / 42679	FlyBaseID:	FBgn0039003	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_035846.1	Gene:	Wfs1 / 22393	MGIID:	1328355	Length:	890	Species:	Mus musculus

Alignment Length:	886	Identity:	216/886 - (24%)
Similarity:	367/886 - (41%)	Gaps:	204/886 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRASLNKLKHHI--------AEEGCPQMQYDLAK---ELLDNSIVEPNLAKGNQSQKAVNWLVSA 75
            |||...|....|        |:.|.|:.|.::.|   .|.:::..|.|      |..||.||:.|
Mouse    76 DRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELN------SCSAVAWLILA 134

  Fly    76 AHNGHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERAARKAA-----------------R 123
            |..|..:||||||:|..|..|||:||..||::..:.|..|||.||||                 .
Mouse   135 AKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVS 199

  Fly   124 ELFACLSNGNEH-------ITPKQLERKMRRIYNLQRKRRR------------------------ 157
            ||...:...||.       ..||.|:::.|.:..|.....:
Mouse   200 ELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPTNL 264

  Fly   158 --RDDDRSSSSSEGEQEPECEPLEDVPTIDLANVERRRLI---------TEAHLVSAASNYSAGQ 211
              :|:|      |.|.|...:..||:|.       |::::         .:.:|:..||......
Mouse   265 FLQDED------EDEDELAGKSPEDLPL-------RQKVVKYPLHAIMEIKEYLIDVASKAGMHW 316

  Fly   212 MPSVNDALTLSVPDPRSLDHVPCFYRMIFHPLIFFTLFYHRLLNLIVSIPNVIPLSVRCSVLVAI 276
            :.::                ||..:   .:.||||.:    :.||.:..
Mouse   317 LSTI----------------VPTHH---INALIFFFI----ISNLTIDF---------------- 342

  Fly   277 SWWSSRHMLPLVSYYLSLGIMIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRN 341
                ....:|||.:|||...|:..|.|:.:..:.:.:||..:.|.|.: :.|::.:.||..|..|
Mouse   343 ----FAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRF-EPNLDVEQAEVNFGWN 402

  Fly   342 NMKPYLYFFCAFICNLIVYPLVTDAWLPHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFA 406
            :::||::|..:.:..:..:||.:...:|.|||.:||...| :|..:|:.:|:.......::...|
Mouse   403 HLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFT-VTSYMSLSSSAEPYTRRALVTEVA 466

  Fly   407 VNVLAKYPYEMDEVVSTRWRFLDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRW 471
            ..:|:..|     .|...||||.:...||.:..:|:.|...::....||:::..|...||:...:
Mouse   467 AGLLSLLP-----TVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVYLFYLFFRMAQLRNF 526

  Fly   472 HGVYTFLIPHCVTLSWLQVCIATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSL 536
            .|.|.:|:|:.|...|.::.:.....||..|::||::|     .||.||.:     |:.||
Mouse   527 KGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIG-----YFLFLFAL-----PILVA---- 577

  Fly   537 GLA----SEQLRW---------GSTALACGLVV-----------VLSCILALNRATQKYITMLQL 577
            |||    .:..||         ..|.:.||:.:           |:..:.:|.::     :|::|
Mouse   578 GLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKS-----SMVKL 637

  Fly   578 ITAITTACLLVLPYMTSSFKDTPRFNAMPRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQ 642
            |....||.||...:.....:....:|             :||.|.::..||.....::.|..:.|
Mouse   638 ILVWLTAILLFCWFYVYRSEGMKVYN-------------STLTWQQYGFLCGPRAWKETNMARTQ 689

  Fly   643 LRCSLLNGMPVIWEGSVTKVEISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKCDPKLDA 707
            :.||.|.|..|.|.|....|.::.:.|..|..| |.||.:||..:|||:||   .:..|.....:
Mouse   690 ILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAI-NMLPFFLGDWMRCLYGE---AYPSCSSGNTS 750

  Fly   708 QCEEWRSVFKTFNAQSGSCTLQRWNRYEYELLVKV--GTKRSGRLLGRSTTTDVILRAHHDFGNF 770
            ..||  .:.:........|.:::::||::|:.|.:  ||..:........|.|::|||..:|.:.
Mouse   751 TAEE--ELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDV 813

  Fly   771 TRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRSR 811
            ...|.:|.::.|..|| ..||.:.....:||.|.|:.|.::
Mouse   814 LLNLRQGSLIEFSTIL-EGRLGSKWPVFELKAISCLNCMTQ 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..154	CDD:223861	48/146 (33%)
Wfs1	NP_035846.1	Interaction with ATP6V1A. /evidence=ECO:0000250\|UniProtKB:O76024	1..323		66/281 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..227		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837640
Domainoid	1	1.000	207	1.000	Domainoid score	I2899
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4380
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3699
Isobase	1	0.950	-	0	Normalized mean entropy	S8020
OMA	1	1.010	-	-		QHG46084
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006904
OrthoInspector	1	1.000	-	-		oto92343
orthoMCL	1	0.900	-	-		OOG6_108955
Panther	1	1.100	-	-	LDO	PTHR13098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5369
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880