Protein Alignment wfs1 and wfs1

DIOPT Version :10

• Sequence 1: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: XP_313695.6
• Gene: wfs1 / 1274554
• VectorBaseID: AGAMI1_008513
• Length: 915
• Species: Anopheles gambiae
• Alignment Length: 946
• Identity: 405/946 - (42%)
• Similarity: 575/946 - (60%)
• Gaps: 124/946 - (13%)

  Fly     1 MATWTQNEPT-----GVTKRRRWNLEDRASLNKLKHHIAEEGCPQMQYDLAKELL-DNSIVEP-- 57
            ||:|....|.     ..:.|::|||||:.||..||:|.||:||.::|:.|||:|| :||..:|
Mosquito     1 MASWANRPPIESNGGSSSSRKKWNLEDKKSLRNLKYHFAEDGCSEVQFALAKQLLEENSETDPAH 65

  Fly    58 NLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERAARKAA 122
            |.|:|      |:||:.||..|||.:::||::||.:|.|||..|.::||..|||:||||:||:||
Mosquito    66 NHAQG------VHWLLRAAQQGHEASIELLKECYENGRGITEANEEDVRTILAMSPGERSARRAA 124

  Fly   123 RELFACLSNGNEHITPKQLERKMRRIYNLQRKRRRRDDDRSSS------------SSEGEQEPEC 175
            :||||.||||.|::|..|||::||.||.:.:||||...|.:.:            .|:|.:.|..
Mosquito   125 QELFASLSNGEEYVTAAQLEKRMREIYKMDKKRRRTQPDGAEAEGSMEHSLGGGGGSDGGRSPAG 189

  Fly   176 EPLEDVPTIDLANVERRRL--------ITEAHLVSAASNYSAGQMPSVNDALTLSVPDPRSLDHV 232
            |     .:|...|....||        |:||||::||.|||.|.:|:|:|||.||.|||.||:||
Mosquito   190 E-----SSIGSPNAGSHRLHRSPTVNHISEAHLLAAAVNYSNGHLPAVSDALMLSSPDPHSLNHV 249

  Fly   233 PCFYRMIFHPLIFFTLFYHRLLNLIVSIPNVIPLSVRCSVLVAISWW-----SSRHMLPLVSYYL 292
            |||:|..|||.:||.|.|||.::|:.:.|.....|.....||.|::|     :...:||:..|||
Mosquito   250 PCFHRPFFHPFMFFQLLYHRFVSLLSTFPGSSGSSWMQLGLVLITYWYFASDNLVSLLPVGGYYL 314

  Fly   293 SLGIMIWATCKMLKTKQQFVDFRIWSGLFLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNL 357
            ||.||:..:.:|||:|.:|:|||:||||||.|||:::..:.:|:::||||:|||.|||.||..|:
Mosquito   315 SLAIMVLCSFRMLKSKHEFIDFRMWSGLFLRYGDEHLNTNDSENQYLRNNLKPYFYFFTAFFVNM 379

  Fly   358 IVYPLVTDAWLPHSELTIISGALTFITMCVSMYASSHQLPDWLVIVSFAVNVLAKYPYEMDEVVS 422
            ::.|.:.|.|||.||:|:::.||||:||...:|.|....||:|::.||.:|||||||||||:||:
Mosquito   380 VLQPNINDQWLPFSEITVLAFALTFLTMFAFIYTSGDSFPDYLILFSFGLNVLAKYPYEMDDVVT 444

  Fly   423 TRWRFLDLRVPTFSSFVIGNGIEFCLNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSW 487
            |.||||||:||.||:||||||||||||||..|||.||..|:.:|:|:.|.|:|.:||||||||:|
Mosquito   445 TGWRFLDLKVPGFSTFVIGNGIEFCLNCRAMLYLMIPGFLMYIARRNNWRGIYQYLIPHCVTLAW 509

  Fly   488 LQVCIATSQSSTVFGVMRAALGLAGIVLFLPLFGIVALLVPVFVAIDSLGLASEQLRWGSTALAC 552
            ||:||.:|||:|:||::|.||||:|::|||||||||.||:|||..|:.|.|:...:|..|:..|.
Mosquito   510 LQICIISSQSATMFGLVRGALGLSGLLLFLPLFGIVTLLIPVFAVIEWLSLSDSTVRLWSSIGAA 574

  Fly   553 GLVVVLSCILALNRATQKYITMLQLITAITTACLLVLPYMTSSFK------------------DT 599
            ...|.:|..:|.:|.|::|:|.||:...:.....|.||:|.|:|:                  |.
Mosquito   575 VTAVAISGYMASSRRTERYVTFLQIAICVIGTIFLTLPHMMSNFETIGVNENRLFESTTSDSLDD 639

  Fly   600 PRFNAMPRAGLHSLSETNTLPWDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEI 664
            ||   .|.:|..:|  .:||.||.::..|.||..:..||:|.||||:.|:|:.|.|||:|..:.|
Mosquito   640 PR---EPTSGGDAL--PSTLSWDTYYQFCHQPAWDTENKVKTQLRCTNLDGILVRWEGTVVDMAI 699

  Fly   665 SRVSNFLEDTIANYLPVWLGRMLRCLHGENISQHFKC---DPKLDAQCEEWRSVFKTFNAQSGSC 726
            |...|.....|..|||.:|...:.|::||.|..  .|   :..::.:||.    .|.|..:..:|
Mosquito   700 SSRRNLRAQLIEGYLPKFLADRITCIYGEPIEP--DCGNLNGSVEGECEN----LKHFMQRQRTC 758

  Fly   727 TLQRWNRYEYELLVKVGTKRSGRLLGRSTTTDVILRAHHDFGNFTRLLSEGDVVLFYGIL----- 786
            .|.:||.|||||.:::.|   |.|   :...:|:|:|.|.|||||:.|:..|.|.|.|:|
Mosquito   759 HLNKWNTYEYELKIRMST---GLL---TKPVEVVLKAQHVFGNFTQSLNYSDRVWFVGVLRDSAQ 817

  Fly   787 ----------------------------------HNSRLLADNVQVKLKTIECVECRSRDLGTAS 817
                                              |:.||...|..|:|.:|.|.:||:.||.|.
Mosquito   818 SGIASSGNTDQPHWDTVSSGFNLNMGGQAGSFGVHSMRLGRKNPLVELHSIGCRQCRNPDLPTV- 881

  Fly   818 IERVVAASPMDARLQDLMRGIKYLLNALLNPLITFK 853
              .:.....::.|::||:||:|||||.:.|||:.||
Mosquito   882 --HLTEGMKVNGRMRDLLRGVKYLLNVIFNPLVIFK 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..121	CDD:440553	44/89 (49%)
		WSLR	79..117	CDD:466262	20/37 (54%)
		WEF-hand	118..208	CDD:466231	42/109 (39%)
		WC-rich	621..730	CDD:466275	38/111 (34%)
		WCOB	731..853	CDD:437745	51/160 (32%)
wfs1	XP_313695.6	None