Protein Alignment wfs1 and wfs1

DIOPT Version :10

• Sequence 1: NP_651079.2
• Gene: wfs1 / 42679
• FlyBaseID: FBgn0039003
• Length: 853
• Species: Drosophila melanogaster
• Sequence 2: NP_001106459.1
• Gene: wfs1 / 100127642
• XenbaseID: XB-GENE-978820
• Length: 863
• Species: Xenopus tropicalis
• Alignment Length: 876
• Identity: 223/876 - (25%)
• Similarity: 390/876 - (44%)
• Gaps: 142/876 - (16%)

  Fly    34 AEEGCPQMQYDLAKELLDNSIVEPNLAKGNQSQKAVNWLVSAAHNGHEDAVKLLRQCYNDGSGIT 98
            |:.|..:.|.::.|..|  .:.|....:.| |..||:||:::|..|..|||||||:|..|..|||
 Frog    70 AKAGDAKAQSEVGKHYL--KLAEEQDEEVN-SCAAVDWLIASAKQGRRDAVKLLRRCLADRRGIT 131

  Fly    99 AENTDEVRRCLAMTPGERAARKAARELFACLSNGNEHITPKQLERKMRRIYNLQRKRRRR----- 158
            .||..||::..:.|..|||.||||..::                      :.|..|::::
 Frog   132 TENESEVKKLSSETDLERAVRKAALVMY----------------------WKLNPKKKKQVSVSE 174

  Fly   159 --DDDRSSSSSEGEQEPECEPLEDVPTIDLANVERR---RLITEA--------HLVSAASNYSAG 210
              ::....::.:|..||.       |....|..:||   ||::..        ..|.....|:.|
 Frog   175 LLENVGQVNAEDGNNEPG-------PIPKAAQKQRRILERLVSSESKSFIALDDFVEITKKYAKG 232

  Fly   211 QMPSVNDALTLSVPDP-------RSLDHVPCFYRMIFHPLIFFTLFYHRLLNLIVS-----IPNV 263
            .:||     .|.:.|.       :..:.:|...:::.:||...|.....|:::...     :..:
 Frog   233 IVPS-----NLIIHDDEDDEFAGKGPEELPLQQKIMKYPLHVITELKEYLIDVASKAGMHWLSTI 292

  Fly   264 IPLSVRCSVLV--------AISWWSSRHMLPLVSYYLSLGIMIWATCKMLKTKQQFVDFRIWSGL 320
            || :...:.|:        .|.:::  ..:|||.:|||...|:..|.|:.:..:.:.:||..:.|
 Frog   293 IP-THHINALIFFFIISNLTIDFFA--FFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDL 354

  Fly   321 FLSYGDQNIEADIAEHRFLRNNMKPYLYFFCAFICNLIVYPLVTDAWLPHSELTIISGALTFITM 385
            .|.: :.|::.:.||..|..|:|:|||||..:....:..:|:....|:|.|||..||...| ||.
 Frog   355 LLRF-EPNLDVEQAEVNFGWNHMEPYLYFLISVFFVIFSFPITDRNWIPCSELATISIFFT-ITS 417

  Fly   386 CVSMYASSHQLPDWLV---IVSFAVNVLAKYPYEMDEVVSTRWRFLDLRVPTFSSFVIGNGIEFC 447
            .:|:..|:.......:   :.:.|:::|...|..:.        :|::...||.:..:|:.|.|.
 Frog   418 YLSLSTSAEPYTRRALMTEVAAGALSLLDHLPISLP--------YLNIFSKTFFTVPVGHFIIFH 474

  Fly   448 LNCRTALYLFIPVLLIMMAKRSRWHGVYTFLIPHCVTLSWLQVCIATSQSSTVFGVMRAALGLAG 512
            ::....|:|.:..|...|||...:.|||.:|:|:.|...|.::.:...:.||..|::||::|...
 Frog   475 ISVPCLLFLHLFYLFFRMAKLRNFKGVYCYLVPYLVCFMWCELSVVIIRESTTIGLIRASVGYFL 539

  Fly   513 IVLFLPLFGIVALLVPVFVAIDSLGLASEQLRWGSTALACGLVVVL--------SCILALNRATQ 569
            .:..||:. ||.::|...|......::.|..:...|.:.|.:.|:|        |.:..:...|:
 Frog   540 FLFALPIL-IVGIVVMCIVHFIKWFISLELTKIVVTLILCTIPVLLRWWSKANYSAVNMVKSLTK 603

  Fly   570 KYITMLQL--ITAITTACLLVLPYMTSSFKDTPRFNAMPRAGLHSLSETNTLPWDRFHALCAQPV 632
            ..|..|.|  ||||...| .|..|.:...|   .:|             :||.|.::..:|....
 Frog   604 SSIVKLILVWITAIMMFC-WVYVYRSEGMK---VYN-------------STLTWHQYGFICGPRA 651

  Fly   633 HEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDTIANYLPVWLGRMLRCLHGENISQ 697
            .::.|..:.|:.||.|.|..|.|.|....|.::.:.|..|..| |.||:.:|..:|||:||   .
 Frog   652 WKETNMARTQILCSHLEGHRVTWTGRFKYVRLTEIDNSAESAI-NMLPLLIGNWMRCLYGE---A 712

  Fly   698 HFKCDPKLDAQCEEWRSVFKTFNAQSGSCTLQRWNRYEYELLVKV---GTKRSGRLLGRSTTTDV 759
            :..|:|:.....||.....|..:..  ||.::|::||::|:.|.:   |...|..:.....|.|:
 Frog   713 YPACEPQNVTMEEEELCRLKFLSKH--SCHMKRFDRYKFEITVGMPFNGVNASKPIEEDDITKDI 775

  Fly   760 ILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRSRDLGTAS----IER 820
            :|||.::|......|.:|.::.|..|| ..||.:.....:||.|.|:.|.:: |..||    ||:
 Frog   776 VLRASNEFKQVLLNLRQGSIIEFSTIL-EGRLGSKWPVFELKAISCLNCMAK-LTPASRHVKIEQ 838

  Fly   821 VVAASPMDARLQDLMRGIKYLLNALLNPLIT 851
                   |.| :|:...:|:..:...:|.::
 Frog   839 -------DWR-RDVHTALKFAFDFFFSPFLS 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wfs1	NP_651079.2	TPR	<34..121	CDD:440553	35/86 (41%)
		WSLR	79..117	CDD:466262	19/37 (51%)
		WEF-hand	118..208	CDD:466231	16/107 (15%)
		WC-rich	621..730	CDD:466275	31/108 (29%)
		WCOB	731..853	CDD:437745	34/128 (27%)
wfs1	NP_001106459.1	WSLR	74..108	CDD:466262	8/33 (24%)
		WSLR	112..150	CDD:466262	19/37 (51%)
		WEF-hand	151..230	CDD:466231	16/88 (18%)
		WC-rich	640..743	CDD:466275	28/102 (27%)
		WCOB	744..849	CDD:437745	30/107 (28%)