Protein Alignment wake and ANKFN1

DIOPT Version :10

• Sequence 1: NP_001287469.1
• Gene: wake / 42676
• FlyBaseID: FBgn0266418
• Length: 1648
• Species: Drosophila melanogaster
• Sequence 2: XP_016879752.1
• Gene: ANKFN1 / 162282
• HGNCID: 26766
• Length: 1170
• Species: Homo sapiens
• Alignment Length: 1309
• Identity: 351/1309 - (26%)
• Similarity: 564/1309 - (43%)
• Gaps: 326/1309 - (24%)

  Fly   343 DNAVQSLGRGLGLGLGEEA-------------------------PRRLSWERRKDSSALQRSASI 382
            ||.::|.|..|.|...:.:                         .:||| .|||.|..
Human     7 DNGMESTGPTLWLSAMDHSVIWRLLFKDRHFTCSKIIGRRFACFAQRLS-HRRKQSQC------- 63

  Fly   383 DSFAEIVFSESPRPSLAVTG--PGACASASGGPSPFSKRPSASSLYSTSTSSSFASQMQAQLNVN 445
                 .:.:||       ||  |..|:||            ||:..:.:.......|||   |::
Human    64 -----DLLNES-------TGQLPTTCSSA------------ASNSINWNCRVKMTQQMQ---NLH 101

  Fly   446 YGDSALGSGSATGGPGSGHHHGASGGGNGGSSASSSRRESMLSPSSTRRSKLTRIIN-----ALF 505
            ...|...|..::.......:...|....|   :.||..|:.....:.|.|.....:|     |:|
Human   102 LCQSKKHSAPSSPNAAKRLYRNLSEKLKG---SHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMF 163

  Fly   506 SAVEHGHLEKARTIL---ESTDVDVNSINNDGLSALDLAVLSNNRSMTRMLLQHGAVEGSQF-SV 566
            .|||...::..:.:|   ...::|:|:.|::||:.||:|:::||..:.|:||:.||.|...| |:
Human   164 EAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSL 228

  Fly   567 DTIGTKLNGLLKDAESRIHDLSGPEGLCPPVFASRPSISSIIIGNSSASVTGCTGSEVEKQIGIW 631
            ::....||.|:::|:.|:.:||..                  :.|...::   ..:|.|||:..|
Human   229 ESRAMHLNTLVQEAQERVSELSAQ------------------VENEGFTL---DNTEKEKQLKAW 272

  Fly   632 ERRVKGLRRLQLGWDQARPPDAPASVVVDVTGDNSISVQILEPF--EGAIGTKFKVQWSTRADFN 694
            |.|.:..||::.|::.||.|:.|.:|.:.||...|::|...||.  ..|:.|::||:||...||:
Human   273 EWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFS 337

  Fly   695 NVVGESELLEWISFHGTMGAQCHISGLTQGRRYFLRAACGNVKGWGTYRTSVPASVVPSTWRDLD 759
            .:.||      |........:|.|:|||.|::||::.:..|:||||..:|:.||...||.|:|.|
Human   338 PLAGE------IIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYD 396

  Fly   760 NREDRFVGRHRILDNLFTAVRLARPADVSELTLDPASAQRRNPKKKTT---------IKQLFSVT 815
            :||.|..|:..:|:.|...||          .|....:.|.:.|.:||         :|.||..:
Human   397 DREPRHKGQSEVLEGLLQQVR----------ALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSS 451

  Fly   816 TKFQKTLRRGIYFSCIIHCDDKVLVTSEDFPPVIEVDESYPSALHMDYYWLMKVACTWEDVKSLR 880
            .||.|||:||:|.:.|.:..|.:|||:||..|::|:|:|:.|::..|:.|..|::|.|||::.||
Human   452 NKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLR 516

  Fly   881 SDMERNLTSA--VHFRTKLLSAVCQMQSALGITDLGQLYYKPLRDAQGTVVLTCVQSVKSQKAVS 943
            ..:..:.:|:  :..|.|:|:|..|:|:.||..:||::||:|::|..|.:::..::.|  :...|
Human   517 QSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREV--EMLYS 579

  Fly   944 ILNSRWVPVSKLQKKLGALH--EDYTINELLISSIGDQLHYQQAALQRLEPGLYLGYLKMQCSID 1006
            ..|.:|:.:||||.:..:|.  |:.|..::|:.:|.|.|.|.:.:.|||.|||||||||:..|:|
Human   580 FFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVD 644

  Fly  1007 QIQVVVPVKTPNVLPHCKVRENSHITAEEWQVLHRYSSDPLRLPLDFSAQGGDGASGATATTEV- 1070
            ||:|:|..|.||:|.|.|:|||::|:.|||:.:.:.|             |.:.......|::.
Human   645 QIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLS-------------GSESMESVDHTSDCP 696

  Fly  1071 QRLFLYDLTNAMHKLFASMNIKIADATTHRLYDVEVIEHSPDISFLVVCPSAESSCAVPGQSELL 1135
            .:||.|:|..|:..|...:||.:..|...|||..||:|...::|||::.|:::..|..|||:...
Human   697 MQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPY 761

  Fly  1136 LQRDDLASLSIQAFEMIHLRTYQPAIIQKYARLSCILELDTALATHSLREAFSSSELQAAKERLA 1200
            .......:|.:|.||::|..:|:...|..|.|||.::|||:.....|||||.|.||:.|||:|..
Human   762 TPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQ 826

  Fly  1201 TLQELSASLTIVWKSVRWLMDVVAYARNKNAQPSLAMREILDFAQQRQDEAVATSAGGSANKQLL 1265
            .:.:....:..||:.:||:||.:.|||.|.....|.:.:::|
Human   827 QVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLID----------------------- 868

  Fly  1266 QLPIRESKFSKTGQGRGSWPGPGTSEDQSQNKPEHSKSEQNLELSAITPVEPASNQVPTQQQQPQ 1330
                                   .|::||..| .:|.|..:::.....|..|
Human   869 -----------------------PSDEQSLKK-INSTSSSHIDCLPSPPPSP------------- 896

  Fly  1331 QQSQQQQLLQVSNISEYAGSICSEVSFRKNSGDSMSSTYTSRSFYSAVDSASDGNSTNSVFAIPP 1395
                                   |:..||...||              ...||..:.:.||.  |
Human   897 -----------------------EMHRRKTVSDS--------------QPCSDEEACSEVFL--P 922

  Fly  1396 SRSDDTLADALR---------HSQAVAAQRKRTSSNIASHTNPLITVHSSSSAPYLAGSSVSLRS 1451
            :.||...:|||.         .|..:|.|   |.|.::.....::.||...:
Human   923 TNSDYDSSDALSPRDLDLVYLSSHDIAQQ---TLSGLSGSAPDVLQVHDVKT------------- 971

  Fly  1452 GNGAFATDLEHKPLKPATKAASSANLREGGPYLKSTLAEL----------------RAVGGEEPV 1500
                        ||.|.......      ||....:.||.                ...||..|:
Human   972 ------------PLGPGQDPQGE------GPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPL 1018

  Fly  1501 ASTSKASSMK-----SLSRQ------SSEEDSASCSSLNAEQTSGIIQVYTAYSTGLASGTSLKI 1554
            ....|....|     ..||.      .||..|.|.|       .||...:.:.:.|||.
Human  1019 GFLGKRKPGKHPHYGGFSRHHRWLRIHSETQSLSLS-------EGIYTQHLSQACGLAQ------ 1070

  Fly  1555 HVTPKTTAR 1563
              .||...|
Human  1071 --EPKEAKR 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wake	NP_001287469.1	ANKYR	<503..>558	CDD:440430	19/57 (33%)
		ANK repeat	503..531	CDD:293786	8/30 (27%)
		ANK repeat	533..558	CDD:293786	10/24 (42%)
		FN3	651..748	CDD:238020	34/98 (35%)
		RA_ANKFN1_like	1535..1631	CDD:340637	7/29 (24%)
ANKFN1	XP_016879752.1	ANKYR	<155..>219	CDD:440430	20/63 (32%)
		ANK repeat	158..192	CDD:293786	8/33 (24%)
		ANK repeat	194..219	CDD:293786	10/24 (42%)
		FN3	292..385	CDD:238020	34/98 (35%)