DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wake and ANKFN1

DIOPT Version :9

Sequence 1:	NP_001287469.1	Gene:	wake / 42676	FlyBaseID:	FBgn0266418	Length:	1648	Species:	Drosophila melanogaster
Sequence 2:	XP_016879752.1	Gene:	ANKFN1 / 162282	HGNCID:	26766	Length:	1170	Species:	Homo sapiens

Alignment Length:	1309	Identity:	351/1309 - (26%)
Similarity:	564/1309 - (43%)	Gaps:	326/1309 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DNAVQSLGRGLGLGLGEEA-------------------------PRRLSWERRKDSSALQRSASI 382
            ||.::|.|..|.|...:.:                         .:||| .|||.|..
Human     7 DNGMESTGPTLWLSAMDHSVIWRLLFKDRHFTCSKIIGRRFACFAQRLS-HRRKQSQC------- 63

  Fly   383 DSFAEIVFSESPRPSLAVTG--PGACASASGGPSPFSKRPSASSLYSTSTSSSFASQMQAQLNVN 445
                 .:.:||       ||  |..|:||            ||:..:.:.......|||   |::
Human    64 -----DLLNES-------TGQLPTTCSSA------------ASNSINWNCRVKMTQQMQ---NLH 101

  Fly   446 YGDSALGSGSATGGPGSGHHHGASGGGNGGSSASSSRRESMLSPSSTRRSKLTRIIN-----ALF 505
            ...|...|..::.......:...|....|   :.||..|:.....:.|.|.....:|     |:|
Human   102 LCQSKKHSAPSSPNAAKRLYRNLSEKLKG---SHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMF 163

  Fly   506 SAVEHGHLEKARTIL---ESTDVDVNSINNDGLSALDLAVLSNNRSMTRMLLQHGAVEGSQF-SV 566
            .|||...::..:.:|   ...::|:|:.|::||:.||:|:::||..:.|:||:.||.|...| |:
Human   164 EAVEQQDMDAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSL 228

  Fly   567 DTIGTKLNGLLKDAESRIHDLSGPEGLCPPVFASRPSISSIIIGNSSASVTGCTGSEVEKQIGIW 631
            ::....||.|:::|:.|:.:||..                  :.|...::   ..:|.|||:..|
Human   229 ESRAMHLNTLVQEAQERVSELSAQ------------------VENEGFTL---DNTEKEKQLKAW 272

  Fly   632 ERRVKGLRRLQLGWDQARPPDAPASVVVDVTGDNSISVQILEPF--EGAIGTKFKVQWSTRADFN 694
            |.|.:..||::.|::.||.|:.|.:|.:.||...|::|...||.  ..|:.|::||:||...||:
Human   273 EWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVVTRYKVEWSMSEDFS 337

  Fly   695 NVVGESELLEWISFHGTMGAQCHISGLTQGRRYFLRAACGNVKGWGTYRTSVPASVVPSTWRDLD 759
            .:.||      |........:|.|:|||.|::||::.:..|:||||..:|:.||...||.|:|.|
Human   338 PLAGE------IIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYD 396

  Fly   760 NREDRFVGRHRILDNLFTAVRLARPADVSELTLDPASAQRRNPKKKTT---------IKQLFSVT 815
            :||.|..|:..:|:.|...||          .|....:.|.:.|.:||         :|.||..:
Human   397 DREPRHKGQSEVLEGLLQQVR----------ALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSS 451

  Fly   816 TKFQKTLRRGIYFSCIIHCDDKVLVTSEDFPPVIEVDESYPSALHMDYYWLMKVACTWEDVKSLR 880
            .||.|||:||:|.:.|.:..|.:|||:||..|::|:|:|:.|::..|:.|..|::|.|||::.||
Human   452 NKFVKTLKRGLYIAVIFYYKDNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLR 516

  Fly   881 SDMERNLTSA--VHFRTKLLSAVCQMQSALGITDLGQLYYKPLRDAQGTVVLTCVQSVKSQKAVS 943
            ..:..:.:|:  :..|.|:|:|..|:|:.||..:||::||:|::|..|.:::..::.|  :...|
Human   517 QSIPISSSSSTVLQTRQKMLAATAQLQNLLGTHNLGRVYYEPIKDRHGNILIVTIREV--EMLYS 579

  Fly   944 ILNSRWVPVSKLQKKLGALH--EDYTINELLISSIGDQLHYQQAALQRLEPGLYLGYLKMQCSID 1006
            ..|.:|:.:||||.:..:|.  |:.|..::|:.:|.|.|.|.:.:.|||.|||||||||:..|:|
Human   580 FFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYHKRSHQRLFPGLYLGYLKLCSSVD 644

  Fly  1007 QIQVVVPVKTPNVLPHCKVRENSHITAEEWQVLHRYSSDPLRLPLDFSAQGGDGASGATATTEV- 1070
            ||:|:|..|.||:|.|.|:|||::|:.|||:.:.:.|             |.:.......|::.
Human   645 QIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLS-------------GSESMESVDHTSDCP 696

  Fly  1071 QRLFLYDLTNAMHKLFASMNIKIADATTHRLYDVEVIEHSPDISFLVVCPSAESSCAVPGQSELL 1135
            .:||.|:|..|:..|...:||.:..|...|||..||:|...::|||::.|:::..|..|||:...
Human   697 MQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPY 761

  Fly  1136 LQRDDLASLSIQAFEMIHLRTYQPAIIQKYARLSCILELDTALATHSLREAFSSSELQAAKERLA 1200
            .......:|.:|.||::|..:|:...|..|.|||.::|||:.....|||||.|.||:.|||:|..
Human   762 TPHSGFLNLPLQMFELVHFCSYREKFISLYCRLSAVVELDSLNTQQSLREAISDSEVAAAKQRHQ 826

  Fly  1201 TLQELSASLTIVWKSVRWLMDVVAYARNKNAQPSLAMREILDFAQQRQDEAVATSAGGSANKQLL 1265
            .:.:....:..||:.:||:||.:.|||.|.....|.:.:::|
Human   827 QVLDFIQQIDEVWREMRWIMDALQYARYKQPVSGLPITKLID----------------------- 868

  Fly  1266 QLPIRESKFSKTGQGRGSWPGPGTSEDQSQNKPEHSKSEQNLELSAITPVEPASNQVPTQQQQPQ 1330
                                   .|::||..| .:|.|..:::.....|..|
Human   869 -----------------------PSDEQSLKK-INSTSSSHIDCLPSPPPSP------------- 896

  Fly  1331 QQSQQQQLLQVSNISEYAGSICSEVSFRKNSGDSMSSTYTSRSFYSAVDSASDGNSTNSVFAIPP 1395
                                   |:..||...||              ...||..:.:.||.  |
Human   897 -----------------------EMHRRKTVSDS--------------QPCSDEEACSEVFL--P 922

  Fly  1396 SRSDDTLADALR---------HSQAVAAQRKRTSSNIASHTNPLITVHSSSSAPYLAGSSVSLRS 1451
            :.||...:|||.         .|..:|.|   |.|.::.....::.||...:
Human   923 TNSDYDSSDALSPRDLDLVYLSSHDIAQQ---TLSGLSGSAPDVLQVHDVKT------------- 971

  Fly  1452 GNGAFATDLEHKPLKPATKAASSANLREGGPYLKSTLAEL----------------RAVGGEEPV 1500
                        ||.|.......      ||....:.||.                ...||..|:
Human   972 ------------PLGPGQDPQGE------GPNPDHSCAEFLHSLTLTGFTPKNHAKTVSGGRPPL 1018

  Fly  1501 ASTSKASSMK-----SLSRQ------SSEEDSASCSSLNAEQTSGIIQVYTAYSTGLASGTSLKI 1554
            ....|....|     ..||.      .||..|.|.|       .||...:.:.:.|||.
Human  1019 GFLGKRKPGKHPHYGGFSRHHRWLRIHSETQSLSLS-------EGIYTQHLSQACGLAQ------ 1070

  Fly  1555 HVTPKTTAR 1563
              .||...|
Human  1071 --EPKEAKR 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wake	NP_001287469.1	ANK	502..>558	CDD:238125	20/63 (32%)
		Ank_4	502..554	CDD:290365	18/59 (31%)
		ANK repeat	503..531	CDD:293786	8/30 (27%)
		ANK repeat	533..558	CDD:293786	10/24 (42%)
		FN3	651..748	CDD:238020	34/98 (35%)
		UBQ	1533..1631	CDD:294102	8/31 (26%)
ANKFN1	XP_016879752.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34996
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1305469at2759
OrthoFinder	1	1.000	-	-		FOG0004745
OrthoInspector	1	1.000	-	-		oto91586
orthoMCL	1	0.900	-	-		OOG6_105454
Panther	1	1.100	-	-	LDO	PTHR21437
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4003
SonicParanoid	1	1.000	-	-		X3340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.950