DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wake and ankfn1

DIOPT Version :9

Sequence 1:	NP_001287469.1	Gene:	wake / 42676	FlyBaseID:	FBgn0266418	Length:	1648	Species:	Drosophila melanogaster
Sequence 2:	XP_031750669.1	Gene:	ankfn1 / 100490095	-ID:	-	Length:	1073	Species:	Xenopus tropicalis

Alignment Length:	1002	Identity:	305/1002 - (30%)
Similarity:	504/1002 - (50%)	Gaps:	163/1002 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 ALFSAVEHGHLEKARTIL---ESTDVDVNSINNDGLSALDLAVLSNNRSMTRMLLQHGAVEGSQF 564
            |:|.|||...|:..:.:|   .:.::|:|:.|::||:.||:||::||..:.|.||:.||.|...|
Frog    67 AVFEAVEQQDLDAVQILLYQYTAEELDLNTPNSEGLTPLDIAVMTNNVPIARTLLKAGARESPHF 131

  Fly   565 -SVDTIGTKLNGLLKDAESRIHDLSGP---EGLCPPVFASRPSISSIIIGNSSASVTGCTGSEVE 625
             |:::....|:.|:::|:.|:.:||..   |||                        |...:|.|
Frog   132 ISMESRSMHLSALVEEAQQRMSELSAKIQNEGL------------------------GGDSTEKE 172

  Fly   626 KQIGIWERRVKGLRRLQLGWDQARPPDAPASVVVDVTGDNSISVQILEPF--EGAIGTKFKVQWS 688
            ||:..||.|.:..:|::.|::.||.|:||.:|.:.:|...|::|...||.  ..|:.||:||:||
Frog   173 KQLKSWEWRYRLYKRMKTGYEHARAPEAPTNVCLMITSSTSLTVTFQEPLSVNSAVVTKYKVEWS 237

  Fly   689 TRADFNNVVGESELLEWISFHGTMGAQCHISGLTQGRRYFLRAACGNVKGWGTYRTSVPASVVPS 753
            ..:||:::.||      |........:|.|:||..|..|:::.:..|:||||....|.|....||
Frog   238 CCSDFSSITGE------IIVDNLHSLKCTIAGLKMGHMYYVQVSACNMKGWGPAEISNPPYAAPS 296

  Fly   754 TWRDLDNREDRFVGRHRILDNLFTAVRLARPADVSELTLDPASAQRRNPKKKTTI----KQLFSV 814
            .|:|.|.|:.|..|:...|:.|...||.     |.:......||:.:|..:|.::    |.||..
Frog   297 NWKDYDGRDFRHKGQSEALERLLQQVRA-----VHQHYSCRESAKLQNSSRKQSVSRSLKHLFHS 356

  Fly   815 TTKFQKTLRRGIYFSCIIHCDDKVLVTSEDFPPVIEVDESYPSALHMDYYWLMKVACTWEDVKSL 879
            :.||.|||:||:|.:.:.:..|.:|||:||..|::|:|:|..|::..|:.|..|::|.|:|::.|
Frog   357 SNKFVKTLKRGLYLAVVFYYKDNMLVTNEDHIPIVEIDDSCTSSIMQDFLWFTKLSCMWDDIRWL 421

  Fly   880 RSDMERNLTS--AVHFRTKLLSAVCQMQSALGITDLGQLYYKPLRDAQGTVVLTCVQSVKSQKAV 942
            |..|..:::|  |:..|.|:|:|..|:|:.||..:||::||:|::|..|.|::..::.|::  ..
Frog   422 RQSMSISMSSSTALQARQKMLAAAAQLQNLLGTHNLGRVYYEPIKDRHGNVLIVSIREVET--LY 484

  Fly   943 SILNSRWVPVSKLQKKLGALH--EDYTINELLISSIGDQLHYQQAALQRLEPGLYLGYLKMQCSI 1005
            |..|.:|:.:||||.:..:|.  |:.|..::|:.:|.:.|.||:.:.|||.|||||||||:..|:
Frog   485 SFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQEILAYQKRSQQRLHPGLYLGYLKLCSSV 549

  Fly  1006 DQIQVVVPVKTPNVLPHCKVRENSHITAEEWQVLHRYSS----DPLRLPLDFSAQGGDGASGATA 1066
            |||:|:|..:.||:|.|.|:|:||:::.:||:.:...|.    |.:.|.||
Frog   550 DQIKVLVSQRLPNMLCHVKIRDNSNVSRDEWEWIQNLSMSESVDSVDLSLD-------------- 600

  Fly  1067 TTEVQRLFLYDLTNAMHKLFASMNIKIADATTHRLYDVEVIEHSPDISFLVVCPSAESSCAVPGQ 1131
              |..:||||||..|:..|...:|:.:..|...|||..||:|...::|||::.|:::..|:.|||
Frog   601 --EHTQLFLYDLKLAVKALLKQINLPLHQAKHFRLYTHEVLELGHNVSFLLLLPASDDVCSAPGQ 663

  Fly  1132 SELLLQRDDLASLSIQAFEMIHLRTYQPAIIQKYARLSCILELDTALATHSLREAFSSSELQAAK 1196
            |..........:|.:|.||::|..:|:...|..|.|||.|:|||:.::..:||||.|..|:.|||
Frog   664 SNPYTPHSGFLNLPLQIFELVHFCSYKETFINLYCRLSAIVELDSLISQQALREAISDDEVVAAK 728

  Fly  1197 ERLATLQELSASLTIVWKSVRWLMDVVAYARNKNAQPSLAMREILDFAQQRQDEAVATSAGGSAN 1261
            :|...:.:.......:|:.:||:||.:.|||||.....|.:...:|.::::
Frog   729 QRHQQVLDYMQQTDEIWREMRWIMDALQYARNKQPAAGLPITRFIDLSEEQ-------------- 779

  Fly  1262 KQLLQLPIRESKFSKTGQGRGSWPGPGTSEDQSQNKP---------EHSKSEQNL-------ELS 1310
                    .:.|.:.|.......|.|..|.:..:.:|         |...||..|       ...
Frog   780 --------NQKKNNSTSSHLDCLPSPSPSPEMHRRRPLSDSQTCSDEEGCSEVFLPTDSDYDSSD 836

  Fly  1311 AITPVE----PASNQVPTQQQQPQQQSQQQQLLQVSN------ISEYAGSICSEVSFRKNSGDSM 1365
            |::|.|    .:|:|..:||...........:|||.:      :.|..|::.:|...:.....|:
Frog   837 ALSPRELDLVYSSSQDISQQAVSCLSGSAPDVLQVHDMKPCLTLKEECGALDTEYCTKHMDNLSV 901

  Fly  1366 SSTYTSRSFYSAVDSASDGNSTNSVFAIPPSRSDDTLADALRHSQAVAAQRKRTSS-----NIAS 1425
            .. |.|:|    :|.|     |||                   .|.::..||:.|.     |..|
Frog   902 MG-YPSKS----IDKA-----TNS-------------------KQHLSLLRKKKSGKHQHCNYFS 937

  Fly  1426 HTNPLITVHSSSSAPYLAGSSVSLRSG 1452
            ..:..:.|||.|.|       :||..|
Frog   938 RHHRWLRVHSESQA-------LSLTEG 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wake	NP_001287469.1	ANK	502..>558	CDD:238125	21/57 (37%)
		Ank_4	502..554	CDD:290365	19/53 (36%)
		ANK repeat	503..531	CDD:293786	9/30 (30%)
		ANK repeat	533..558	CDD:293786	11/24 (46%)
		FN3	651..748	CDD:238020	33/98 (34%)
		UBQ	1533..1631	CDD:294102
ankfn1	XP_031750669.1	Ank_2	69..>122	CDD:423045	19/52 (37%)
		ANK repeat	100..125	CDD:293786	11/24 (46%)
		FN3	198..284	CDD:238020	31/91 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1151
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34996
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1263
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1305469at2759
OrthoFinder	1	1.000	-	-		FOG0004745
OrthoInspector	1	1.000	-	-		otm49411
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060