DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wake and ankfn1

DIOPT Version :9

Sequence 1:	NP_001287469.1	Gene:	wake / 42676	FlyBaseID:	FBgn0266418	Length:	1648	Species:	Drosophila melanogaster
Sequence 2:	XP_021336045.1	Gene:	ankfn1 / 100333998	ZFINID:	ZDB-GENE-130603-21	Length:	1418	Species:	Danio rerio

Alignment Length:	1511	Identity:	411/1511 - (27%)
Similarity:	675/1511 - (44%)	Gaps:	298/1511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 HTDKQTFQL----DERLLGSKSRSGSASGHRW-----SLLTRATNSSSMCSNNNPASSSSSSSNN 159
            ||..:.:::    |:.:|...|.|..:....|     :||.|:.:  |:||...|:..:.::..:
Zfish    76 HTANEKYEIPGMGDDSVLEMLSYSKFSDLETWLCMPSTLLPRSRD--SVCSLPPPSHENGTADTD 138

  Fly   160 NNNLHMANNNNTLMVKSLNLPKDDSNLVYRRKSSGSTPHQHQNAHHHHQQHHHLQQQQQQQQQHQ 224
            ..:....|.       |:||                                   .|.|:::.|.
Zfish   139 RESRPPENT-------SINL-----------------------------------SQCQERKTHL 161

  Fly   225 QQQLQQQQMLQHLGDSSLFQLSDDFECHADGSLLLR-----IPAPHVVAAR-AYRLAARKRAAAS 283
                        |..|||..:|    .....|..||     :|.|:..:.: ...:..|:|.|||
Zfish   162 ------------LPPSSLMPVS----ASPTSSTPLRTTSTPLPKPNRDSGQGGVSVRKRRRLAAS 210

  Fly   284 S-----EASTPMTREHTLHEMP-LAESACSGSATGSGTTFTRLAK---LLHQSSTLAGRSNLQPP 339
            .     :||..:.|:|...|.| |:|......:..|.:....|.:   .|.::.::..|...|.|
Zfish   211 PGGLHWDASGSVLRDHDRGETPSLSEVKRFPRSVDSESLVPELWRDRAPLRKTISIDDRLLQQTP 275

  Fly   340 PMADNAVQSLGRGL-------GLGLGEEAPRRLSWERRKDS--SAL-QRSASIDSFAEIVFSESP 394
            ......:..|.||.       .||    |..|....::.:|  |.| ||.....|.|.::  :..
Zfish   276 REHHRLLSRLERGKKKLRNINSLG----ATGRYETHKKSESRISRLAQRLNQRQSDAALI--KDF 334

  Fly   395 RPSLAVTGPGACASASGGPSPFSKRPSASSLYSTSTSSSFASQMQAQLNVNYGDSALGSGSATGG 459
            ||...::|       |.|        |:.|| ..:.|.|.:.|||   |:....|..|:|.|:..
Zfish   335 RPLFLLSG-------SAG--------SSQSL-DRNFSISMSQQMQ---NLQLTQSKKGAGPASPS 380

  Fly   460 PGSGHHHGASGGGNGGSSASSSRRESMLSPSSTRRSKLTRI--INALFSAVEHGHLEKARTIL-- 520
            .....:...|....|   :.||..::.....|.|..|::.|  ..|||.|||...|:..:.:|
Zfish   381 AAKRLYRNLSEKFKG---SHSSFEDAYFFGRSDRIRKVSNIQSSEALFEAVEQQDLDAVQILLFQ 442

  Fly   521 -ESTDVDVNSINNDGLSALDLAVLSNNRSMTRMLLQHGAVEGSQF-SVDTIGTKLNGLLKDAESR 583
             .:.::|:|:.|::||:.||:::::||..:.::||:.|..|...| |:::....|:.|:::|:.|
Zfish   443 YTADELDLNTPNSEGLTPLDISIMTNNVPIAKLLLKAGGKESPHFVSLESRDAHLSALVQEAQRR 507

  Fly   584 IHDLSGPEGLCPPVFASRPSISSIIIGNSSASVTGCTGSEVEKQIGIWERRVKGLRRLQLGWDQA 648
            ..:||..        ..|.|:|             ...|:.|||:..||.|.|..:|::.|::.|
Zfish   508 ASELSNQ--------VMRESLS-------------LETSDKEKQLKAWEWRCKLYKRMRTGFEHA 551

  Fly   649 RPPDAPASVVVDVTGDNSISVQILEP--FEGAIGTKFKVQWSTRADFNNVVGESELLEWISFHGT 711
            |.|:||..|.:.|||..:::|...||  ...|:.||:||:||...||:.:.||      :.....
Zfish   552 RQPEAPLMVRLSVTGSTTLTVSFQEPASMNSAVVTKYKVEWSCLKDFSLLAGE------LILENL 610

  Fly   712 MGAQCHISGLTQGRRYFLRAACGNVKGWGTYRTSVPASVVPSTWRDLDNREDRFVGRHRILDNLF 776
            ...:|.|:|||.||:|:::.:..|:||||..:.|.|.|.|||.|:|.|.||.|..|....::.|.
Zfish   611 QSLKCTITGLTMGRQYYVQVSAYNMKGWGPAQLSQPPSAVPSNWKDCDGRESRRRGHIEAMERLL 675

  Fly   777 TAVRLARP----ADVSELTLDPASAQRRNPKKKTTI----KQLFSVTTKFQKTLRRGIYFSCIIH 833
            ..||....    .|.|:|         :||.:|.::    |.||..:|||.|:|:||:|.:.:.:
Zfish   676 QQVRATHQHYCCGDTSKL---------QNPSRKQSVSRSLKHLFHSSTKFVKSLKRGVYIASVFY 731

  Fly   834 CDDKVLVTSEDFPPVIEVDESYPSALHMDYYWLMKVACTWEDVKSLRSDM--ERNLTSAVHFRTK 896
            ..|.:|||:||..|::|||:||.|:|..|:.|..|::|.||||:.||..:  ..:.:|.:..|.|
Zfish   732 HKDSLLVTNEDQIPIVEVDDSYSSSLMQDFLWFTKLSCMWEDVRWLRQSLAVSTSSSSTLQSRQK 796

  Fly   897 LLSAVCQMQSALGITDLGQLYYKPLRDAQGTVVLTCVQSVKSQKAVSILNSRWVPVSKLQ---KK 958
            :|:|..|:|:.||..:||:::|:|::|..|.|:|..|:.:.|  ..|..|.:|:.|||||   |.
Zfish   797 MLAAAGQLQNLLGTHNLGRVHYEPIKDRHGNVLLVTVREMDS--LYSFFNGKWMQVSKLQSQRKS 859

  Fly   959 LGALHEDYTINELLISSIGDQLHYQQAALQRLEPGLYLGYLKMQCSIDQIQVVVPVKTPNVLPHC 1023
            |....|.|.::.||| :|.|.|.||:.:..||..||||||||:..|:|||:|:||.:.||:|.|.
Zfish   860 LSTPEEPYALDILLI-TIQDILAYQRRSQHRLSSGLYLGYLKLSSSVDQIKVLVPQRMPNMLCHT 923

  Fly  1024 KVRENSHITAEEWQVLHRYSSDPLRLPLDFSAQGGDGASGATATTEVQRLFLYDLTNAMHKLFAS 1088
            |:|:|.:::.:||:.|...|.     |::  .:..|.|:|....:|:|        .|:..|...
Zfish   924 KIRDNWNVSRDEWEWLQSLSG-----PVE--VERADQATGCLLFSELQ--------TAIKSLLHQ 973

  Fly  1089 MNIKIADATTHRLYDVEVIEHSPDISFLVVCPSAESSCAVPGQSELLLQRDDLASLSIQAFEMIH 1153
            :|:.:..|...|||..||:|...::|||::.|:::..|:.|||:..........:|.:|.||::|
Zfish   974 INLPLHQAKHFRLYTHEVLELGHNVSFLLLLPASDDVCSAPGQTNPYTPHSGFLNLPLQMFELVH 1038

  Fly  1154 LRTYQPAIIQKYARLSCILELDTALATHSLREAFSSSELQAAKERLATLQELSASLTIVWKSVRW 1218
            ..:|:...|..|.|||.:|:||..:...:.|||.:.||:..||:|...:.:....|..:|:.|||
Zfish  1039 FCSYKEKFISLYCRLSSVLDLDALITQQAFREAITDSEVSTAKQRHQHILDYIQQLDEMWREVRW 1103

  Fly  1219 LMDVVAYARNKNAQPSLAMREILDFA----QQRQDEAVATSAGGSANKQLLQLPIRESKFSKTGQ 1279
            :.:.:.|||.|.....:.:..::|.:    .|:.|..       |:|...:..|....:..:...
Zfish  1104 ITNALQYARYKQPLGWVPITWLVDVSVEPPVQKNDST-------SSNTDYVPTPSPSPEMRRRKP 1161

  Fly  1280 GRGSWPG---PGTSEDQSQNKPEHSKSEQNLELSAITP----VEPASNQVPTQQQQPQQQSQQQQ 1337
            ...|.||   .|.||.......::..|:      |::|    :..:|.|..:.|...........
Zfish  1162 TIESQPGSDEEGCSEVFLPTDSDYDSSD------ALSPRDLDLVYSSAQDLSHQAVHVLSGSAPD 1220

  Fly  1338 LLQVSNISEYAGSICSE-----VSFRKNSGDSMSSTYTSRSFYSAVDSASDGNSTNSVFAIPPSR 1397
            :||:.:: :|  |:||:     .|..|:..|...|:|:.::        :|          .|||
Zfish  1221 VLQMHDL-KY--SVCSKSILETESCTKDLEDLSLSSYSVKT--------TD----------KPSR 1264

  Fly  1398 SDDTLADALRHSQAVAAQRKRTSSNIASHTNP----------LITVHSSSSAPYLAGSSVSLRSG 1452
            | ..||||            .|...:.|.::|          .:.|.|.|..|       ||..|
Zfish  1265 S-KFLADA------------PTKRKLLSKSHPQRSYFGGPHRWLRVQSESHTP-------SLSEG 1309

  Fly  1453 NGAFATDLE---HKPLKPATKAASSANL-------REGGPYLKSTLAELRAVGGEEPVASTSKAS 1507
            .....:|::   ..||.......:|.:|       ||..|.::....|           |.||.|
Zfish  1310 IYTRQSDIDLPLETPLSIPHSPTTSYSLDEYRQPYRESKPNVRRIFVE-----------SCSKTS 1363

  Fly  1508 SMKSLSRQSSEEDSAS 1523
            ..:.......||:..|
Zfish  1364 PCRDAPHWEEEEEKGS 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wake	NP_001287469.1	ANK	502..>558	CDD:238125	19/58 (33%)
		Ank_4	502..554	CDD:290365	17/54 (31%)
		ANK repeat	503..531	CDD:293786	10/30 (33%)
		ANK repeat	533..558	CDD:293786	8/24 (33%)
		FN3	651..748	CDD:238020	35/98 (36%)
		UBQ	1533..1631	CDD:294102
ankfn1	XP_021336045.1	Ank_2	<423..480	CDD:315466	19/56 (34%)
		ANK repeat	423..454	CDD:293786	10/30 (33%)
		ANK repeat	456..480	CDD:293786	8/23 (35%)
		FN3	554..640	CDD:238020	33/91 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H34996
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1305469at2759
OrthoFinder	1	1.000	-	-		FOG0004745
OrthoInspector	1	1.000	-	-		oto41199
orthoMCL	1	0.900	-	-		OOG6_105454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820