DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and CYTIP

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	336	Identity:	70/336 - (20%)
Similarity:	130/336 - (38%)	Gaps:	89/336 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SGPAPISTSTTPSGSNSQQHQRR--------------RKKRA--------NYNYNGIRTVEVRRG 77
            :||| .|:.:|.:||.:....||              ||:.|        :::::..:.|.|.:.
Human    20 AGPA-YSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLALTRSSSLSDFSWSQRKLVTVEKQ 83

  Fly    78 YN-GFGFTISGQQP-----C-----RLSC-IISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVV 130
            .| .|||.|...:|     |     .|.| |...|||..|||::||.|.::||::.....::.||
Human    84 DNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPAHCAGLQAGDVLANINGVSTEGFTYKQVV 148

  Fly   131 QLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKL 195
            .||.:|...:.::                 ||.|.::.       :....:|||..|:.:.::|.
Human   149 DLIRSSGNLLTIE-----------------TLNGTMIL-------KRTELEAKLQVLKQTLKQKW 189

  Fly   196 NPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALE---------C 251
                 || ::|....:|..|.....:.|...|:.  .|..::...:...|.|.::         |
Human   190 -----VE-YRSLQLQEHRLLHGDAANCPSLENMD--LDELSLFGPLPGPGPALVDRNRLSSESSC 246

  Fly   252 RVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYS 316
            :   .:|.::.|..:..:       ::|:   .::..:........|.|...:.......|...|
Human   247 K---SWLSSMTMDSEDGY-------QTCV---SEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSS 298

  Fly   317 SARLNFVSSSS 327
            |.|...:|::|
Human   299 SRRNRSISNTS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	28/87 (32%)
		PTB_RGS12	251..391	CDD:269984	12/77 (16%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	28/84 (33%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810