DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Pard3

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_006531583.1	Gene:	Pard3 / 93742	MGIID:	2135608	Length:	1337	Species:	Mus musculus

Alignment Length:	1037	Identity:	201/1037 - (19%)
Similarity:	340/1037 - (32%)	Gaps:	303/1037 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HPPLPITGASGSTAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGI 69
            ||.||            .:|.|....|||   ||....|...:...|..:.::..||.|
Mouse   418 HPRLP------------HSAHASTKPPAA---PALAPPSVLSTNVGSVYNTKKVGKRLN------ 461

  Fly    70 RTVEVRRGYNGFGF-------TISGQQPCRLSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPH 126
              :::::|..|.||       ||.|..|..:..|:....|.|.| |::||.||.|||::::....
Mouse   462 --IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQ 524

  Fly   127 ETVVQLIGNS--FGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRN 189
            |.||.|:.::  .|::.:.:..       .||..|               ||
Mouse   525 EEVVSLLRSTKMEGTVSLLVFR-------QEEAFH---------------PR------------- 554

  Fly   190 SPQKKLNPPEAVEPHKSKSSPDHPTLKP------VLEDPPLTANLSKAADV-----------ANV 237
              :....|.:...|.::|:..:...|.|      :..:.||..:.|....|           |::
Mouse   555 --EMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL 617

  Fly   238 SAMVRAV---GSAALECRVIVGYLGTIEMPKQISHSSKLQTV--RSCIRKLRQEKRQPTIVLMCI 297
            ...|:::   |:|:.:.|:.|              :.:|..|  .|.:.|..||       .|..
Mouse   618 GIFVKSIINGGAASKDGRLRV--------------NDQLIAVNGESLLGKANQE-------AMET 661

  Fly   298 TPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGH 362
            ...|:|.:.:..|::....:.|:     |..:|.|..|  :.|.....||.|.:..        .
Mouse   662 LRRSMSTEGNKRGMIQLIVARRI-----SRCNELRSPG--SPAAPELPIETELDDR--------E 711

  Fly   363 ISISHSCHVFV--IDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMR 425
            ..||||.:..:  :|.....:|. |.|......:|...|..|:    |::...::...|    :.
Mouse   712 RRISHSLYSGIEGLDESPTRNAA-LSRIMGESGKCQLSPTVNM----PHDDTVMIEDDR----LP 767

  Fly   426 ILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEIS---------TTTSNSDSGIGFNND 481
            :|||    |.:|..:.                  |:|.::.         ...:.|||.     |
Mouse   768 VLPP----HLSDQSSS------------------SSHDDVGFIMTEAGTWAKATISDSA-----D 805

  Fly   482 CTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIV----------GIPDNRLTVRAMPD 536
            |:...|...|:.|...|.|..:.:......: :.|..|..|          ||.| ...:..:.|
Mouse   806 CSLSPDVDPVLAFQREGFGRQSMSEKRTKQF-SDASQLDFVKTRKSKSMDLGIAD-ETKLNTVDD 868

  Fly   537 HSALLRSPP----ASSSLRRPNLLASFNL------------IQSPATNLTSTRSCDDVLNLFVD- 584
            ..|  .||.    .|..|::.:.|.|...            ...|...:...|.|::.....:|
Mouse   869 QRA--GSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDK 931

  Fly   585 --DSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQP 647
              |.|     :...||..:.:.....:|.         .|..|.|::..:....:.|..|:.|.|
Mouse   932 SYDKP-----MVDDDDEGMETLEEDTEES---------SRSGRESVSTSSDQPSYSLERQMNGDP 982

  Fly   648 GSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDL 712
            ..|        |..:.....|..|:..|          ..|::..:.|...   :|:........
Mouse   983 EKR--------DKTERKKDKAGKDKKKD----------REKEKDKLKAKKG---MLKGLGDMFRF 1026

  Fly   713 GNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDM-----YIKTL 772
            |............|...|.|| |...|:|..:::|....:..|......|.:.|.     :.:|.
Mouse  1027 GKHRKDDKMEKMGRIKIQDSF-TSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTF 1090

  Fly   773 MLDSDL------------------KSSRSQHQLSLL--QVPKVLTT-PAPPSAITASVAAEGAAQ 816
            ..|.:|                  :|.|..|.:..|  ||.|..:: |...:..|.|
Mouse  1091 GCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPS-------- 1147

  Fly   817 DHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACE------RYRL-LESEADRVA 874
            :|.........|::..||..     .|..::.:|.|.  .|::..      |:.: :|.:..|..
Mouse  1148 NHDRIQRLRQEFQQAKQDED-----VEDRRRTYSFEQ--SWSSSRPASQSGRHSVSVEVQVQRQR 1205

  Fly   875 Q-AREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMK----FDSYQ 931
            | .||.|.:.....||.|......|.|:::    |:....:||.:.  |...|    :.|||
Mouse  1206 QEERESFQQAQRQYSSLPRQSRKNASSISQ----DSWEQNYAPGEG--FQSAKENPRYSSYQ 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	25/85 (29%)
		PTB_RGS12	251..391	CDD:269984	29/143 (20%)
		RGS_R12-like	828..941	CDD:188661	27/116 (23%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Pard3	XP_006531583.1	DUF3534	2..83	CDD:338230
		PDZ_signaling	272..347	CDD:238492
		PDZ_signaling	465..544	CDD:238492	25/78 (32%)
		PDZ_signaling	588..681	CDD:238492	20/113 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900