DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and DLG5

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:850 Identity:171/850 - (20%)
Similarity:271/850 - (31%) Gaps:309/850 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 RRRKKRANYNYNGIRTVEVRRGYNGFG-------FTISGQQPCRLS--------CIISSSPAEQA 105
            :::..:|..|..|...:.|||..:..|       ..:|||:...:|        .::..|||.:.
Human   688 KKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKE 752

  Fly   106 G-LRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSS-DEENAHATLRGQLLA 168
            | |..||.::::||:.:..........|:.:...|:.:.:.:.:...|| ..:|....::.....
Human   753 GSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKM 817

  Fly   169 ASLR-HKPRF-LHHKAKLHRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKA 231
            .|.| |.|.. .|:|..|.:..||.|..:...:.:|..|....|.                    
Human   818 LSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPG-------------------- 862

  Fly   232 ADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMC 296
                         ||::...:...|  |.:::..|                            .|
Human   863 -------------GSSSFLHKPFPG--GPLQVCPQ----------------------------AC 884

  Fly   297 ITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLV----------------TSAVHNTQ 345
            .:....||           ||.|      |..|.:|.||||                ...|....
Human   885 PSASERSL-----------SSFR------SDASGDRGFGLVDVRGRRPLLPFETEVGPCGVGEAS 932

  Fly   346 IEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNN 410
            :::.....:.|........:|.:    .:..||..:.:..||...|      ||.:....:.|..
Human   933 LDKADSEGSNSGGTWPKAMLSST----AVPEKLSVYKKPKQRKSIF------DPNTFKRPQTPPK 987

  Fly   411 SEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTS---NS 472
            .:|            :||            |.|         .|||||||..:...|...   .|
Human   988 IDY------------LLP------------GPG---------PAHSPQPSKRAGPLTPPKPPRRS 1019

  Fly   473 DSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDH 537
            || |.|.:.....|:            ..|....:.|.|.|..|.|      ||   .....|.|
Human  1020 DS-IKFQHRLETSSE------------SEATLVGSSPSTSPPSALP------PD---VDPGEPMH 1062

  Fly   538 SALLRSPPASSSLRRPNLLAS--FNLIQSPATNLTSTRSCD-DVLNLFVDD-------------- 585
            :    |||..:.:|    :||  :......:::|.:.:||| |:.:..||:              
Human  1063 A----SPPRKARVR----IASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSF 1119

  Fly   586 ----SPRTLAA--------VASMDDISLHSAAPSLDE------GHTFAH--PACVPRK-----MR 625
                :|..:.|        |.:..::|     |.|.|      ||:..|  |...|.:     :.
Human  1120 RPKLAPVVIPAQFLEEQKCVPASGELS-----PELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVP 1179

  Fly   626 RSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKS--HK 688
            |||      ||....:.:...|          |.:|:|...|.|........|..|.||.|  |:
Human  1180 RSL------TPSTTVSSILRNP----------IYTVRSHRVGPCSSPPAARDAGPQGLHPSVQHQ 1228

  Fly   689 DRTSMSAS---SSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSS---FR--------TPRSD 739
            .|.|:..|   .|.:..:.||:     |:.:||::|     ..|.||   |:        |||..
Human  1229 GRLSLDLSHRTCSDYSEMRATH-----GSNSLPSSA-----RLGSSSNLQFKAERIKIPSTPRYP 1283

  Fly   740 K--VAKEQQQLGQS-------SPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKV 795
            :  |..|:..:..|       ||                    |:.|..||.||.|.|...:|::
Human  1284 RSVVGSERGSVSHSECSTPPQSP--------------------LNIDTLSSCSQSQTSASTLPRI 1328

  Fly   796 LTTPA 800
            ...||
Human  1329 AVNPA 1333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 19/91 (21%)
PTB_RGS12 251..391 CDD:269984 23/155 (15%)
RGS_R12-like 828..941 CDD:188661
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142
Takusan 130..212 CDD:282652
TPR_MLP1_2 231..353 CDD:285204
COG1340 295..587 CDD:224259
FliJ 310..449 CDD:304890
BAR 417..601 CDD:299863
PDZ_signaling 620..707 CDD:238492 3/18 (17%)
DegQ <702..771 CDD:223343 17/68 (25%)
PDZ_signaling 722..790 CDD:238492 15/67 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 53/267 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 6/34 (18%)
PDZ 1347..1429 CDD:214570
dbPDZ_assoc 1427..1499 CDD:293216
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493
PDZ 1499..1582 CDD:214570
SH3_DLG5 1597..1659 CDD:212794
GuKc 1732..1908 CDD:214504
Guanylate_kin 1740..1907 CDD:279019
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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