DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and RGS9

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_003826.2	Gene:	RGS9 / 8787	HGNCID:	10004	Length:	674	Species:	Homo sapiens

Alignment Length:	458	Identity:	103/458 - (22%)
Similarity:	162/458 - (35%)	Gaps:	151/458 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   728 WGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQV 792
            :|......|...||.::|..:.....:            ||.:..::.|.:|||     :||..:
Human   203 YGLDRVTNPNEVKVNQKQTVVAVKKEI------------MYYQQALMRSTVKSS-----VSLGGI 250

  Fly   793 PKVLTTPAPPSAITASVAAEGAAQDHGC-PSS---------------------------WAGSFE 829
            .|.....:...||.:           || ||:                           ||.:|.
Human   251 VKYSEQFSSNDAIMS-----------GCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFS 304

  Fly   830 RMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQ-AREIFAKHLANNSSDPVN 893
            .:::|..|.|:|..|||||||.||:.||.|||  .|...:..:|.: |.||:...||..:...:|
Human   305 ELIRDPKGRQSFQYFLKKEFSGENLGFWEACE--DLKYGDQSKVKEKAEEIYKLFLAPGARRWIN 367

  Fly   894 VDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLD 958
            :|.:...:|.:.|......:...||..|:.|||.|||.|:::|.:||
Human   368 IDGKTMDITVKGLKHPHRYVLDAAQTHIYMLMKKDSYARYLKSPIYK------------------ 414

  Fly   959 LDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRK---------------TRSKSRD---RT 1005
                          ..|.|:....|..::.|.||:.|:               ..:|:|:   ..
Human   415 --------------DMLAKAIEPQETTKKSSTLPFMRRHLRSSPSPVILRQLEEEAKAREAANTV 465

  Fly  1006 EIMADMQHALMPAP----------PVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTAT 1060
            :|....|| :.|:|          |...::|.:|                |.||....| |..:.
Human   466 DITQPGQH-MAPSPHLTVYTGTCMPPSPSSPFSS----------------SCRSPRKPF-ASPSR 512

  Fly  1061 GGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDV 1125
            ..:..||....|..||.| :.::.:.|  .||..|.:.           |....|.:.|..|:|.
Human   513 FIRRPSTTICPSPIRVAL-ESSSGLEQ--KGECSGSMA-----------PRGPSVTESSEASLDT 563

  Fly  1126 QQP 1128
            ..|
Human   564 SWP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	42/113 (37%)
		RGS12_RBD	1073..1145	CDD:176412	13/56 (23%)
		RBD	1144..1213	CDD:128731
RGS9	NP_003826.2	DEP_RGS7-like	22..109	CDD:239897
		GGL	224..283	CDD:128520	15/86 (17%)
		RGS_RGS9	295..415	CDD:188693	45/153 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..573		10/47 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810