DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and RGS20

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_733466.1	Gene:	RGS20 / 8601	HGNCID:	14600	Length:	388	Species:	Homo sapiens

Alignment Length:	480	Identity:	110/480 - (22%)
Similarity:	166/480 - (34%)	Gaps:	170/480 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 PTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPAS--SSLRRPNLLASFNLIQSPATNLTST 572
            |.:.|......|..|.:|...:||:||..:.   |||.  .|...|.|   |.|:.||.::|...
Human    27 PLFRAQRYNTDIHQITENEGDLRAVPDIKSF---PPAQLPDSPAAPKL---FGLLSSPLSSLARF 85

  Fly   573 RSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPH 637
            .|                                     |....|.  |...||.|.. :|..|
Human    86 FS-------------------------------------HLLRRPP--PEAPRRRLDF-SPLLP- 109

  Fly   638 KLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCL 702
                   ..|.:|.|.|.|.:....|.:.||.:
Human   110 -------ALPAARLSRGHEELPGRLSLLLGAAL-------------------------------- 135

  Fly   703 LEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQ---LGQSSPV---------R 755
                         |||...|      |....|.|.  .|||.:::   .|||||:         .
Human   136 -------------ALPGRPS------GGRPLRPPH--PVAKPREEDATAGQSSPMPQMGSERMEM 179

  Fly   756 RTASMNASDN---------------------------DMYIKTLMLDSDLKSSRSQHQLSLLQVP 793
            |...|.|:.:                           .....|:....|.:.:.:.|:|. ..:|
Human   180 RKRQMPAAQDTPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVRNQEDQRPTIASHELR-ADLP 243

  Fly   794 KVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWT 858
            ....:|||.....               ::||.||::::...||...|.|||:.|||.||:.||.
Human   244 TWEESPAPTLEEV---------------NAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWM 293

  Fly   859 ACERYRLLESEADR---VAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQ 920
            |||.   |:.||::   ..:||.|:..:::..|...|::||:.|.:....:.:.:..||..||.|
Human   294 ACEE---LKKEANKNIIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVEPSQHIFDDAQLQ 355

  Fly   921 IFSLMKFDSYQRFIRSDLYKSCVEA 945
            |::||..|||.||:.|.:||..:::
Human   356 IYTLMHRDSYPRFMNSAVYKDLLQS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	43/115 (37%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
RGS20	NP_733466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..199		16/68 (24%)
RGS20	NP_733466.1	RGS_RGS20	221..376	CDD:188700	54/173 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810