DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and RGS8

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_203131.1	Gene:	RGS8 / 85397	HGNCID:	16810	Length:	198	Species:	Homo sapiens

Alignment Length:	150	Identity:	52/150 - (34%)
Similarity:	78/150 - (52%)	Gaps:	7/150 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 PAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERY 863
            |..|:.....::.|.|.:       ||.||:.:|....|:..|..|||.|||.||:.||.|||.:
Human    53 PDKPNRALKRLSTEEATR-------WADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEF 110

  Fly   864 RLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFD 928
            :...|.|..|::|..||.:.:...:...||:|.|.|..|.:.|.:.:...|..||.::.|||:.|
Human   111 KKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKD 175

  Fly   929 SYQRFIRSDLYKSCVEAEQK 948
            ||.||:||.:|...:...|:
Human   176 SYPRFLRSKMYLDLLSQSQR 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	44/112 (39%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
RGS8	NP_203131.1	RGS_RGS8	64..188	CDD:188666	49/130 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810