DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and Rgs2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_445905.1	Gene:	Rgs2 / 84583	RGDID:	621665	Length:	211	Species:	Rattus norvegicus

Alignment Length:	174	Identity:	48/174 - (27%)
Similarity:	86/174 - (49%)	Gaps:	25/174 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 KSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSE 843
            |:.:...|.:.::       |:|..|:.                 ||.:|:.:|....|:..|..
  Rat    59 KTGKKSKQQTFIK-------PSPEEALL-----------------WAEAFDELLASKYGLAAFRA 99

  Fly   844 FLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLAD 908
            |||.||..|||.||.|||.::..:|.....::||:|:...:...:...:|:|.|.::|..:.:.:
  Rat   100 FLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQE 164

  Fly   909 AAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKS-CVEAEQKNQP 951
            |....|..|||:::|||:.:||.||:.|:.|:. |.:.:...:|
  Rat   165 ATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEP 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	39/112 (35%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Rgs2	NP_445905.1	Necessary for membrane association. /evidence=ECO:0000250\|UniProtKB:P41220	32..66		1/6 (17%)
		Necessary to inhibit protein synthesis. /evidence=ECO:0000250\|UniProtKB:P41220	79..116		16/53 (30%)
		RGS_RGS2	84..197	CDD:188664	39/112 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810