DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and AXIN2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_004646.3	Gene:	AXIN2 / 8313	HGNCID:	904	Length:	843	Species:	Homo sapiens

Alignment Length:	888	Identity:	177/888 - (19%)
Similarity:	295/888 - (33%)	Gaps:	263/888 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   796 LTTPAPPSAIT-----ASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIY 855
            :|.|.|.|:.|     .....||.|......:.|..|...:|.|..|...|..||::|...:.:.
Human    45 VTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLD 109

  Fly   856 FWTACERYR---LLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPD----- 912
            ||.||..:|   |.:::..|||:|  |:.:::.|||.    |..|.:..|:..:.|....
Human   110 FWFACNGFRQMNLKDTKTLRVAKA--IYKRYIENNSI----VSKQLKPATKTYIRDGIKKQQIDS 168

  Fly   913 -IFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLK 976
             :|..||.:|.|:|:.::||.|:.||:|...|.:..:|           ....:|..||:...:
Human   169 IMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGEN-----------TAYMSNGGLGSLKVV- 221

  Fly   977 KSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSL 1041
                       ...||    |.::..:.|  .||.:..|.|..     ..|:|.:|:......|.
Human   222 -----------CGYLP----TLNEEEEWT--CADFKCKLSPTV-----VGLSSKTLRATASVRST 264

  Fly  1042 SDLHSSRSS------LSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVER 1100
            ..:.|...|      ::.:..|:......|::.:...:....|||.:.::..:.        |:.
Human   265 ETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSS--------VDG 321

  Fly  1101 LLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVI-----ERRVAFKLDLPDP-----KVI 1155
            :        |.|.:   ||.|.:..:....:.|..:|.:     ..|:..::...:|     ::|
Human   322 I--------PPYRV---GSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELI 375

  Fly  1156 SVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRD-----------------TQVPIDL------- 1196
            |...|.|.:|.       |:::.: |::|.|..|                 ||.|:.|
Human   376 SRLEKLKLELE-------SRHSLE-ERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYE 432

  Fly  1197 NQPVTMADGQRLRIVMV------------------------NSDFQ--VGGGSSMPPKQSKP-MK 1234
            ..|.|:.|....|::..                        :|.:.  :..|..:||..:.| ..
Human   433 EDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGAC 497

  Fly  1235 PL--PQGHLDELTNK-VFNELL------ASKADAAASEKSRPVDLC----------SMKSNEAPS 1280
            ||  .:|.:.:.|.| |.:..:      .:|.:..|....|....|          ..||:....
Human   498 PLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAP 562

  Fly  1281 ETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQ 1345
            ||      |..:|..|..  .|.|||...|.|                          :.|:.|.
Human   563 ET------MPSEQFGGSR--GSTLPKRNGKGT--------------------------EPGLALP 593

  Fly  1346 VTERVAEHQDELLEGLKRAQLARLEDQRGTEI-NFDLPDFLKNKENLSAAVSKLRKVRASLSPVS 1409
            ..|..|.      .|....||.|.|..|..:: .:.|....::|....:|.|..:..     |:.
Human   594 AREGGAP------GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAY-----PLE 647

  Fly  1410 KVPATPTE-------------IPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAP 1461
            ...::|.|             .|:..||..:. :|.|..|..........|..|.:...|.:|
Human   648 SARSSPGERASRHHLWGGNSGHPRTTPRAHLF-TQDPAMPPLTPPNTLAQLEEACRRLAEVSK-- 709

  Fly  1462 PPLPPKPKVLPI---KPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASK-PGTFA----------- 1511
               |||.:....   :..|......||  ...:|.....|...||..| .|..|
Human   710 ---PPKQRCCVASQQRDRNHSATVQTG--ATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYF 769

  Fly  1512 ---SKIP---------LDLG--RKSLEEAGSRCAYLDEPSSSF 1540
               .:||         |.||  ::.|.:.|:...|..:.|..|
Human   770 FCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEF 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	37/121 (31%)
		RGS12_RBD	1073..1145	CDD:176412	12/76 (16%)
		RBD	1144..1213	CDD:128731	19/97 (20%)
AXIN2	NP_004646.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		8/29 (28%)
		AXIN1_TNKS_BD	10..73	CDD:293252	8/27 (30%)
		Tankyrase-binding motif	21..30
		RGS_Axin	82..198	CDD:188662	37/121 (31%)
		Interaction with GSK3B. /evidence=ECO:0000250	327..413		17/96 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..435		7/38 (18%)
		Interaction with beta-catenin. /evidence=ECO:0000250	413..476		8/62 (13%)
		Axin_b-cat_bind	432..467	CDD:285982	4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..494		4/46 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..674		29/157 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..748		5/31 (16%)
		DAX	761..843	CDD:197474	10/52 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810