DRSC/TRiP Functional Genomics Resources

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Protein Alignment loco and AXIN2

DIOPT Version :10

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_004646.3 Gene:AXIN2 / 8313 HGNCID:904 Length:843 Species:Homo sapiens


Alignment Length:888 Identity:177/888 - (19%)
Similarity:295/888 - (33%) Gaps:263/888 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   796 LTTPAPPSAIT-----ASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIY 855
            :|.|.|.|:.|     .....||.|......:.|..|...:|.|..|...|..||::|...:.:.
Human    45 VTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLD 109

  Fly   856 FWTACERYR---LLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPD----- 912
            ||.||..:|   |.:::..|||:|  |:.:::.|||.    |..|.:..|:..:.|....     
Human   110 FWFACNGFRQMNLKDTKTLRVAKA--IYKRYIENNSI----VSKQLKPATKTYIRDGIKKQQIDS 168

  Fly   913 -IFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLK 976
             :|..||.:|.|:|:.::||.|:.||:|...|.:..:|           ....:|..||:...: 
Human   169 IMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGEN-----------TAYMSNGGLGSLKVV- 221

  Fly   977 KSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSL 1041
                       ...||    |.::..:.|  .||.:..|.|..     ..|:|.:|:......|.
Human   222 -----------CGYLP----TLNEEEEWT--CADFKCKLSPTV-----VGLSSKTLRATASVRST 264

  Fly  1042 SDLHSSRSS------LSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVER 1100
            ..:.|...|      ::.:..|:......|::.:...:....|||.:.::..:.        |:.
Human   265 ETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSS--------VDG 321

  Fly  1101 LLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVI-----ERRVAFKLDLPDP-----KVI 1155
            :        |.|.:   ||.|.:..:....:.|..:|.:     ..|:..::...:|     ::|
Human   322 I--------PPYRV---GSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELI 375

  Fly  1156 SVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRD-----------------TQVPIDL------- 1196
            |...|.|.:|.       |:::.: |::|.|..|                 ||.|:.|       
Human   376 SRLEKLKLELE-------SRHSLE-ERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYE 432

  Fly  1197 NQPVTMADGQRLRIVMV------------------------NSDFQ--VGGGSSMPPKQSKP-MK 1234
            ..|.|:.|....|::..                        :|.:.  :..|..:||..:.| ..
Human   433 EDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGAC 497

  Fly  1235 PL--PQGHLDELTNK-VFNELL------ASKADAAASEKSRPVDLC----------SMKSNEAPS 1280
            ||  .:|.:.:.|.| |.:..:      .:|.:..|....|....|          ..||:....
Human   498 PLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAP 562

  Fly  1281 ETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQ 1345
            ||      |..:|..|..  .|.|||...|.|                          :.|:.|.
Human   563 ET------MPSEQFGGSR--GSTLPKRNGKGT--------------------------EPGLALP 593

  Fly  1346 VTERVAEHQDELLEGLKRAQLARLEDQRGTEI-NFDLPDFLKNKENLSAAVSKLRKVRASLSPVS 1409
            ..|..|.      .|....||.|.|..|..:: .:.|....::|....:|.|..:..     |:.
Human   594 AREGGAP------GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAY-----PLE 647

  Fly  1410 KVPATPTE-------------IPQPAPRLSITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAP 1461
            ...::|.|             .|:..||..:. :|.|..|..........|..|.:...|.:|  
Human   648 SARSSPGERASRHHLWGGNSGHPRTTPRAHLF-TQDPAMPPLTPPNTLAQLEEACRRLAEVSK-- 709

  Fly  1462 PPLPPKPKVLPI---KPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASK-PGTFA----------- 1511
               |||.:....   :..|......||  ...:|.....|...||..| .|..|           
Human   710 ---PPKQRCCVASQQRDRNHSATVQTG--ATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYF 769

  Fly  1512 ---SKIP---------LDLG--RKSLEEAGSRCAYLDEPSSSF 1540
               .:||         |.||  ::.|.:.|:...|..:.|..|
Human   770 FCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEF 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_RGS12-like 70..145 CDD:467194
PTB_RGS12 251..391 CDD:269984
RGS_R12-like 828..941 CDD:188661 37/121 (31%)
RBD1_RGS12_like 1072..1141 CDD:340515 11/73 (15%)
RBD2_RGS12_like 1142..1212 CDD:340587 20/98 (20%)
GoLoco 1354..1375 CDD:214645 6/20 (30%)
AXIN2NP_004646.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..75 8/29 (28%)
AXIN1_TNKS_BD 10..75 CDD:465215 8/29 (28%)
Tankyrase-binding motif 21..30
RGS_Axin 82..198 CDD:188662 37/121 (31%)
Interaction with GSK3B. /evidence=ECO:0000250 327..413 17/96 (18%)
Interaction with SIAH1 and SIAH2. /evidence=ECO:0000269|PubMed:28546513 334..393 10/66 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..435 7/38 (18%)
Interaction with beta-catenin. /evidence=ECO:0000250 413..476 8/62 (13%)
Axin_b-cat_bind 433..468 CDD:462616 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..494 4/46 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..674 29/157 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..748 5/31 (16%)
DAX 761..843 CDD:197474 10/52 (19%)
Blue background indicates that the domain is not in the aligned region.

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