DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and AXIN1

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_011520984.1 Gene:AXIN1 / 8312 HGNCID:903 Length:916 Species:Homo sapiens


Alignment Length:1016 Identity:202/1016 - (19%)
Similarity:335/1016 - (32%) Gaps:369/1016 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   647 PGSRHSLGFEAI---DSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNS 708
            |||||....:.:   .:|.:.|.|.                             |:||.| ..:.
Human    14 PGSRHHRARDRLIHFGAVSTDVLGC-----------------------------SAHCSL-TQSP 48

  Fly   709 EPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMN-ASDNDMYIKTL 772
            :.::..:..|.:..   .::.:.:.|.|    |..|:.:|..:.|  |.||.: .|...:.||. 
Human    49 KMNIQEQGFPLDLG---ASFTEDAPRPP----VPGEEGELVSTDP--RPASYSFCSGKGVGIKG- 103

  Fly   773 MLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAG 837
              ::...:.| :..|.|...|:...:|.||..                  .||.|...:|.|..|
Human   104 --ETSTATPR-RSDLDLGYEPEGSASPTPPYL------------------KWAESLHSLLDDQDG 147

  Fly   838 MQTFSEFLKKEFSAENIYFWTACERYRLLE----SEADRVAQAREIFAKHLANNSSDPVNVDSQA 898
            :..|..|||:|..|:.:.||.||..:|.||    :|..|:..||.|:.|::.:|:.   .|..|.
Human   148 ISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNG---IVSRQT 209

  Fly   899 RSLTE--------EKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLY-----------KSCVE 944
            :..|:        ::|.|  |.:|..||.:|.:.|:.::|..|::||:|           |.|  
Human   210 KPATKSFIKGCIMKQLID--PAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC-- 270

  Fly   945 AEQKNQPLPYSGL-----------------DLDE----------------LLKTNFHLGAFSKLK 976
            ::|.:......|:                 |:||                ||:|     |..::.
Human   271 SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLET-----AAPRVS 330

  Fly   977 KSASNAEDRR------RKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLV 1035
            .|...:|.|.      |:.:.|::              .:..:||         ||.|||:    
Human   331 SSRRYSEGREFRYGSWREPVNPYY--------------VNAGYAL---------APATSAN---- 368

  Fly  1036 CGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVER 1100
                     .|.:.|||| ||.|.:                 |||                    
Human   369 ---------DSEQQSLSS-DADTLS-----------------LTD-------------------- 386

  Fly  1101 LLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVIS--------- 1156
                                .|:|...|.:|.......::..|.....:|.|.:.|         
Human   387 --------------------SSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPSCPSQRTYRV 431

  Fly  1157 ---VKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQ 1218
               |:.:|:|...|:|        :::|.|| ..|:.:..::          :||:.|.:..:.:
Human   432 PKEVRVEPQKFAEELI--------HRLEAVQ-RTREAEEKLE----------ERLKRVRMEEEGE 477

  Fly  1219 VGGGSSMPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSET- 1282
            .|..||.||.....:.|.|..|                     ....|.||:......:|..|. 
Human   478 DGDPSSGPPGPCHKLPPAPAWH---------------------HFPPRCVDMGCAGLRDAHEENP 521

  Fly  1283 -SSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSE------EAATTQAVADPKKPIIAKLKA 1340
             |.|.|.::|..|    .|..:.|....:|..|...::      .||:......||..  |||.|
Human   522 ESILDEHVQRVLR----TPGRQSPGPGHRSPDSGHVAKMPVALGGAASGHGKHVPKSG--AKLDA 580

  Fly  1341 G-------VKLQVTERVAEHQDEL-LEGLKRAQLA---RLED------QRGTEINF----DLPDF 1384
            .       |...|....|..:::: .|..:|||.:   .||.      .||...:.    :..|.
Human   581 AGLHHHRHVHHHVHHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDG 645

  Fly  1385 LKNKENLSAAVSK-LRKVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPETDLP 1448
            |.:...:..|..: .:|..:..|..::||....:          ....|.:....::.|.|....
Human   646 LAHSGKVGVACKRNAKKAESGKSASTEVPGASED----------AEKNQKIMQWIIEGEKEISRH 700

  Fly  1449 AATQDQTEFAKAPPPLP-PKPKVL-----------PIKPSNWGVAQPTGNYCNKYSPSKQVPTSP 1501
            ..|...:...:.|.|.. .:|..|           .::||:..:..||            :|  |
Human   701 RRTGHGSSGTRKPQPHENSRPLSLEHPWAGPQLRTSVQPSHLFIQDPT------------MP--P 751

  Fly  1502 KEASKPGTFASKIPLDLGRKSLEE-------AGSRCAYLDE 1535
            ..|..|.|     .|:..|:.|||       |.|:..|:.|
Human   752 HPAPNPLT-----QLEEARRRLEEEEKRASRAPSKQRYVQE 787

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492
PTB_RGS12 251..391 CDD:269984
RGS_R12-like 828..941 CDD:188661 39/135 (29%)
RGS12_RBD 1073..1145 CDD:176412 8/71 (11%)
RBD 1144..1213 CDD:128731 15/80 (19%)
AXIN1XP_011520984.1 Axin_TNKS_binding 60..129 CDD:211424 17/81 (21%)
RGS_Axin 138..258 CDD:188662 39/124 (31%)
Axin_b-cat_bind 518..574 CDD:285982 13/59 (22%)
DIX 836..911 CDD:279160
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.