DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Pard3

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_112514.1 Gene:Pard3 / 81918 RGDID:620374 Length:1337 Species:Rattus norvegicus


Alignment Length:1037 Identity:204/1037 - (19%)
Similarity:341/1037 - (32%) Gaps:303/1037 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 HPPLPITGASGSTAVGTGAAAAEDASPAANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGI 69
            ||.|| ..|..||...|..|.|.         |..:|||.     .|..:.:|..||.|      
  Rat   418 HPRLP-HSAHASTKPPTAPALAP---------PNVLSTSV-----GSVYNTKRVGKRLN------ 461

  Fly    70 RTVEVRRGYNGFGF-------TISGQQPCRLSCIISSSPAEQAG-LRSGDFLISVNGLNVSKLPH 126
              :::::|..|.||       ||.|..|..:..|:....|.|.| |::||.||.|||::::....
  Rat   462 --IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQ 524

  Fly   127 ETVVQLIGNS--FGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRN 189
            |.||.|:.::  .|::.:.:..       .||..|               ||             
  Rat   525 EEVVSLLRSTKMEGTVSLLVFR-------QEEAFH---------------PR------------- 554

  Fly   190 SPQKKLNPPEAVEPHKSKSSPDHPTLKP------VLEDPPLTANLSKAADV-----------ANV 237
              :....|.:...|.::|:..:...|.|      :..:.||..:.|....|           |::
  Rat   555 --EMNAEPSQMQSPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADL 617

  Fly   238 SAMVRAV---GSAALECRVIVGYLGTIEMPKQISHSSKLQTV--RSCIRKLRQEKRQPTIVLMCI 297
            ...|:::   |:|:.:.|:.|              :.:|..|  .|.:.|..||       .|..
  Rat   618 GIFVKSIINGGAASKDGRLRV--------------NDQLIAVNGESLLGKANQE-------AMET 661

  Fly   298 TPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGH 362
            ...|:|.:.:..|::....:.|:     |..:|.|..|  :.|.....||.|.:..        .
  Rat   662 LRRSMSTEGNKRGMIQLIVARRI-----SRCNELRSPG--SPAAPELPIETELDDR--------E 711

  Fly   363 ISISHSCHVFV--IDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMR 425
            ..||||.:..:  :|.....:|. |.|......:|...|..|:    |::...::...|    :.
  Rat   712 RRISHSLYSGIEGLDESPTRNAA-LSRIMGESGKCQLSPTVNM----PHDDTVMIEDDR----LP 767

  Fly   426 ILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEIS---------TTTSNSDSGIGFNND 481
            :|||    |.:|..:.                  |:|.::.         ...:.|||.     |
  Rat   768 VLPP----HLSDQSSS------------------SSHDDVGFIMTEAGTWAKATISDSA-----D 805

  Fly   482 CTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIV----------GIPDNRLTVRAMPD 536
            |:...|...|:.|...|.|..:.:......: :.|..|..|          ||.| ...:..:.|
  Rat   806 CSLSPDVDPVLAFQREGFGRQSMSEKRTKQF-SNASQLDFVKTRKSKSMDLGIAD-ETKLNTVDD 868

  Fly   537 HSALLRSP----PASSSLRRPNLLASFNL------------IQSPATNLTSTRSCDDVLNLFVD- 584
            ..|  .||    ..|..|::.:.|.|...            ...|...:...|.|::.....:| 
  Rat   869 QRA--GSPNRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDK 931

  Fly   585 --DSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQP 647
              |.|     :...||..:.:.....:|.         .|..|.|::..:....:.|..|:.|.|
  Rat   932 SYDKP-----MVDDDDEGMETLEEDTEES---------SRSGRESVSTSSDQPSYSLERQMNGDP 982

  Fly   648 GSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDL 712
            ..|        |..:.....|..|:..|          ..|::..:.|...   :|:........
  Rat   983 EKR--------DKAEKKKDKAGKDKKKD----------REKEKDKLKAKKG---MLKGLGDMFRF 1026

  Fly   713 GNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDM-----YIKTL 772
            |............|...|.|| |...|:|..:::|....:..|......|.:.|.     :.:|.
  Rat  1027 GKHRKDDKMEKMGRIKIQDSF-TSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTF 1090

  Fly   773 MLDSDL------------------KSSRSQHQLSLL--QVPKVLTT-PAPPSAITASVAAEGAAQ 816
            ..|.:|                  :|.|..|.:..|  ||.|..:: |...:..|.|        
  Rat  1091 GCDDELLYGGMSSYDGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPS-------- 1147

  Fly   817 DHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACE------RYRL-LESEADRVA 874
            :|.........|::..||..     .|..::.:|.|.  .|::..      |:.: :|.:..|..
  Rat  1148 NHDRIQRLRQEFQQAKQDED-----VEDRRRTYSFEQ--SWSSSRPASQSGRHSVSVEVQVQRQR 1205

  Fly   875 Q-AREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMK----FDSYQ 931
            | .||.|.:.....||.|......|.|:::    |:....:||.:.  |...|    :.|||
  Rat  1206 QEERESFQQAQRQYSSLPRQSRKNASSVSQ----DSWEQNYAPGEG--FQSAKENPRYSSYQ 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 25/85 (29%)
PTB_RGS12 251..391 CDD:269984 29/143 (20%)
RGS_R12-like 828..941 CDD:188661 27/116 (23%)
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
Pard3NP_112514.1 DUF3534 1..146 CDD:288873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..109
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..263
PDZ_signaling 272..347 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..441 10/32 (31%)
PDZ_signaling 465..544 CDD:238492 25/78 (32%)
PDZ_signaling 588..681 CDD:238492 20/113 (18%)
Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269|PubMed:9763423 712..936 49/263 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..888 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1015 19/114 (17%)
Interaction with FRMD4A. /evidence=ECO:0000250|UniProtKB:Q99NH2 935..1337 72/384 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1055 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1110..1271 38/173 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1337
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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