DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and PDZD7

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_001182192.1 Gene:PDZD7 / 79955 HGNCID:26257 Length:1033 Species:Homo sapiens


Alignment Length:1423 Identity:248/1423 - (17%)
Similarity:410/1423 - (28%) Gaps:572/1423 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 GYLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARL 320
            |.|.::.....:...|.....|..:||.::....|        |..:...|..|.|:...|....
Human    20 GSLSSLSSRGHLGSDSGSTATRYLLRKQQRLLNGP--------PRGIRASSPMGRVILINSPIEA 76

  Fly   321 NFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHL 385
            |    |.||:         .:|:.::|:......|.:...|.   .|...:||   ..:|.....
Human    77 N----SDESD---------IIHSVRVEKSPAGRLGFSVRGGS---EHGLGIFV---SKVEEGSSA 122

  Fly   386 QRAHEFRLQCTRDPI---SNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAA 447
            :||.    .|..|.|   :.|.||.......|          ::|..:||.|......|   ...
Human   123 ERAG----LCVGDKITEVNGLSLESTTMGSAV----------KVLTSSSRLHMMVRRMG---RVP 170

  Fly   448 G-----------------------GAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRI 489
            |                       |:..:..|.:......:...|::.|..:|||          
Human   171 GIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYTTSDDFCLGFN---------- 225

  Fly   490 LVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPN 554
                 :..|                  :..|: ||..:::      ||..|...           
Human   226 -----IRGG------------------KEFGL-GIYVSKV------DHGGLAEE----------- 249

  Fly   555 LLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPAC 619
                           ...:..|.||          .|.....|||| ||.|..:.:|.|  |...
Human   250 ---------------NGIKVGDQVL----------AANGVRFDDIS-HSQAVEVLKGQT--HIML 286

  Fly   620 VPRKMRRSLALETPTTPH----KLSAQVFGQ--PGSRHSLGFEAIDSVQSSVSGA---------- 668
            ..::..|..|.:...:.:    :||..|..|  |.|      |:..||.|..|.|          
Human   287 TIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPAS------ESSSSVSSCASSAPYSSGSLPSD 345

  Fly   669 ----CMDQ-------------------------TMDTWASLQ-------------NLHKSHKDRT 691
                |:.|                         .::||.|::             ..|...:..:
Human   346 RMDICLGQEEPGSRGPGWGRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDS 410

  Fly   692 SMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRR 756
            ::|.|..:..||..:...|            |..|:   .|:.|...:|..:::::.|  ||..:
Human   411 ALSESPKTALLLALSRPRP------------PITRS---QSYLTLWEEKQQRKKEKSG--SPGEK 458

  Fly   757 TASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQ----D 817
            .|...:       |||| :...|..|.                       ..:|.:|..:    |
Human   459 GALQRS-------KTLM-NLFFKGGRQ-----------------------GRLARDGRREAWTLD 492

  Fly   818 HGCPSSWAGSFERM-LQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFA 881
            .|   |.|.::.|: ::.|.|:....:|:.          |.       |..:.:|   .|.:.:
Human   493 SG---SLAKTYPRLDIEKAGGVGPVQKFVT----------WR-------LRRDQER---GRALLS 534

  Fly   882 KHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAE 946
            ....:.||...|||.|                                             |:|.
Human   535 ARSGSPSSQLPNVDEQ---------------------------------------------VQAW 554

  Fly   947 QKNQPLPYSGLDLDELLKTN-------------FHLGAFSKLKKSASNAEDRRRKSLLPWHRKTR 998
            :..:||..   ||.:.|.|:             .|.|....|.:......||..|.||       
Human   555 ESRRPLIQ---DLAQRLLTDDEVLAVTRHCSRYVHEGGIEDLVRPLLAILDRPEKLLL------- 609

  Fly   999 SKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRS-----SLSSFDAGT 1058
                     :.|::..:.|                        :||....|     .|.:|:|  
Human   610 ---------LQDIRSVVAP------------------------TDLGRFDSMVMLVELEAFEA-- 639

  Fly  1059 ATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYP-------YYDIVF 1116
                               |...|......||..      :....||:|:.|       :|.:..
Human   640 -------------------LKSRAVRPPALRPAR------QDTPPKRHLITPVPDSRGGFYLLPV 679

  Fly  1117 QGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPDPKVISVKSKPKKQLHEVIRPILSKYNYKME 1181
            .|..:..|..:          :.||..|.|        :|..:...:..|:.|.|:         
Human   680 NGFPEEEDNGE----------LRERLGALK--------VSPSASAPRHPHKGIPPL--------- 717

  Fly  1182 QVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTN 1246
                    ..||:|...|:.:|                    ..||.|..|:.|.|......||.
Human   718 --------QDVPVDAFTPLRIA--------------------CTPPPQLPPVAPRPLRPNWLLTE 754

  Fly  1247 KVFNE-----LLASKADAAASEKSRPVDLCSMKSNE-------------APSETSSLFERMRR-- 1291
            .:..|     .:..:|.:.:..:||.....|....:             |||.|:..:.:.|:  
Human   755 PLSREHPPQSQIRGRAQSRSRSRSRSRSRSSRGQGKSPGRRSPSPVPTPAPSMTNGRYHKPRKAR 819

  Fly  1292 ----QQRDGGNIPASKLPKLKKKSTSSSQ-QSEEAATTQAVADPKKPIIAKLKAGVKLQVT---- 1347
                :..||   .|:|:...:..|.|.:: .::|||......:.|...::|:|..:.:.::    
Human   820 PPLPRPLDG---EAAKVGAKQGPSESGTEGTAKEAAMKNPSGELKTVTLSKMKQSLGISISGGIE 881

  Fly  1348 ---------ERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENL-----SAAVSKL 1398
                     |::.......|.|..:|             .|:|  ...:.|||     ..||..:
Human   882 SKVQPMVKIEKIFPGGAAFLSGALQA-------------GFEL--VAVDGENLEQVTHQRAVDTI 931

  Fly  1399 R-----KVRASLSPVSKVPATPTEIPQPAPRLSITRSQQPVSPMKVDQEPE-TDLPAATQDQTEF 1457
            |     |.|..:..|.:||. |:..|.|:...::|....|...:...|..: ..:||      .:
Human   932 RRAYRNKAREPMELVVRVPG-PSPRPSPSDSSALTDGGLPADHLPAHQPLDAAPVPA------HW 989

  Fly  1458 AKAPPPLPPKPKVLPIKPSNWGVAQPTGNYCNKYSPSKQVPTSPKEASKPGTFASKIP 1515
            ...||..|..|      |::..:.|||.:...  ||:.|.|.| |.|..|     :||
Human   990 LPEPPTNPQTP------PTDARLLQPTPSPAP--SPALQTPDS-KPAPSP-----RIP 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492
PTB_RGS12 251..391 CDD:269984 26/134 (19%)
RGS_R12-like 828..941 CDD:188661 14/113 (12%)
RGS12_RBD 1073..1145 CDD:176412 13/78 (17%)
RBD 1144..1213 CDD:128731 11/68 (16%)
PDZD7NP_001182192.1 PDZ_signaling 84..164 CDD:238492 21/99 (21%)
PDZ_signaling 209..289 CDD:238492 26/158 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..380 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..464 5/21 (24%)
HN_PDZD7_like 554..630 CDD:259824 19/118 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 754..864 20/112 (18%)
PDZ_signaling 860..948 CDD:238492 18/102 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 943..1033 27/110 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.