DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Rgs12

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_006504183.1 Gene:Rgs12 / 71729 MGIID:1918979 Length:1451 Species:Mus musculus


Alignment Length:1564 Identity:431/1564 - (27%)
Similarity:648/1564 - (41%) Gaps:388/1564 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 IRTVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLI 133
            :|:|||.||..|:|||:|||.||.|||::..|||:..|||:||.::::|.:||.|..||.||:||
Mouse    19 VRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAINEINVKKASHEDVVKLI 83

  Fly   134 GNSFGSIRMQIAE---NYYSDSSDEENAHATLRGQL------LAASLRHKPRFLHH--------- 180
            |...|.:.|.|||   :..|.|||||......:|.|      .|..:....|.:..         
Mouse    84 GKCSGVLHMVIAEGTSHVESCSSDEEGGLYEGKGWLRPKLDSKALGINRAERVVEEVQSGGIFNM 148

  Fly   181 ---------------KAKLHRLRNSPQKKLNPPEA--VEPHKSKSSPDHPTLKPVLEDPPLTANL 228
                           |.|...|..|...:|:..:|  ..||.|..|.:..: |.:.:|...|..|
Mouse   149 IFESSSLCASGPEPLKLKQRSLSESAALRLDAGQAGLCAPHPSMLSKEDIS-KVINDDSVFTVGL 212

  Fly   229 SKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMP---KQISHSSKLQTVRSCIRKLRQEKRQP 290
            ....|.        .:.::.|...::|||||:||:|   ..:.|.| ||.:|.|:|:||.|::..
Mouse   213 DSHDDF--------GLDASILNVAMVVGYLGSIELPSTSSNLEHDS-LQAIRGCMRRLRAEQKIH 268

  Fly   291 TIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAG 355
            ::|.|.:..|.:.|.:...||:|.|.:.:|.| |:....:.|||||||...::.          |
Mouse   269 SLVTMKVMHDCVQLVTDRAGVVAEYPAEKLAF-SAVCPDDRRFFGLVTMQTNDD----------G 322

  Fly   356 SAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRS 420
            ..|.....::..|||||::|..|..|..|...|..|...||.||.::.|||||.:|..|:..:..
Mouse   323 GLAQEDEGALRTSCHVFMVDPDLFHHKIHQGIARRFGFACTADPDTSGCLEFPASSLPVLQFISV 387

  Fly   421 MYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIG-FNNDCTN 484
            :|          ....:...|..|.|.....|.||    .|:|    |:|||||||| ||.:  .
Mouse   388 LY----------RDMGELIEGVRARAFLDGDADAH----QNNS----TSSNSDSGIGNFNQE--E 432

  Fly   485 ISDRILVVDFLAAGAGAAAAAHAGPPTYPA----PARPLGIVGIPDNRLTVRAMPDHSALLRSPP 545
            .|:|:||||.   |.|::.......|.:.:    .::|.             :.|.:.|......
Mouse   433 KSNRVLVVDL---GGGSSRHGQGSSPGWESGGGRGSQPW-------------SAPWNGAFCHDSE 481

  Fly   546 ASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMD---DISLHSAAPS 607
            |.|.|                                 :.||.|       |   |::.||...|
Mouse   482 AGSPL---------------------------------ETSPNT-------DRFWDLTKHSGPVS 506

  Fly   608 LDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFE----AIDSVQSSVSGA 668
                    |....|..:|.|:      .|.|.     |..||  |.||.    .:..:|....|.
Mouse   507 --------HMEVPPATLRSSI------PPSKR-----GAAGS--SCGFNQRWLPVHVLQEWQCGH 550

  Fly   669 CMDQ-----TMDTWASLQ------NLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANAS 722
            ..||     :.|.|:|:.      .:.|...||..:..|.:.                   |..|
Mouse   551 ASDQESYTDSTDGWSSVNCGTLPPPMSKIPADRYRVEGSFAQ-------------------APLS 596

  Fly   723 PFRRAWGQSSF---------RTPRSDKVAKEQQQLGQSSPVRRTA---------------SMNAS 763
            ..:|.|.:.:|         |..|..|..|:..:||:...:.:|:               |:..|
Mouse   597 TQKRDWSRKAFGMQNLFGPHRNVRKTKEDKKSSKLGRGVALAQTSQRTSARRSFGRSRRFSITRS 661

  Fly   764 DNDMYIKTL----MLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSW 824
            .:|:...|:    :..:|||...|.:.||        :..:.||..:.....|...      :||
Mouse   662 LDDLESATVSDGELTGADLKDCISNNSLS--------SNASLPSVQSCRRLRERRV------ASW 712

  Fly   825 AGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLL--ESEADRVAQAREIFAKHLANN 887
            |.||||:|||..|::.||:||:||||.|||.||.|||.:..:  ..:.:...:|||||:|.|.:.
Mouse   713 AVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKKELSYRAREIFSKFLCSK 777

  Fly   888 SSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPL 952
            ::.|||:||||: |.::.|....||:|...|.|||:|||||||.||::|.||:.||.||.:.:.|
Mouse   778 ATTPVNIDSQAQ-LADDILNAPHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVEGRTL 841

  Fly   953 PYS-----------GLDLDEL-LKTNFHLGAFSKLKKSAS------NAEDRRRKSLLPWHRKTRS 999
            |.|           .:..|.. :.|...|...||..:|.:      ::|.:||.:...|   :||
Mouse   842 PDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKSGRSLNEDVGEEDSEKKRRGAFFSW---SRS 903

  Fly  1000 KSRDRTEIMADM-QHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLHSSRSSLSSFDAGTATGGQ 1063
            :|..|::...|. .||        .:||..:..|   |.:.|    ..|.||..|.|...|....
Mouse   904 RSTGRSQKKKDHGDHA--------HDAPHANGGL---CRRES----QGSVSSAGSLDLSEACRTS 953

  Fly  1064 GASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDVQQP 1128
            ....:.....|.|.|.||.:.:|..:.|.::.|::..|.|:..:.....|:...|..|.:.:.|.
Mouse   954 ALEKDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLCERHGINGAAVDLFLVGGDKPLVLHQD 1018

  Fly  1129 SQILAGKEVVIERRVAFKLDL-PDPKVISVKSKPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQV 1192
            |.|||.:::.:|:|..|:||| |..:.:.:|:||.|.:.||:||:::||...:..:.|.:...:.
Mouse  1019 SSILATRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKE 1083

  Fly  1193 PIDLNQPVTMADGQRLRIV-------MVNSDFQVGGGSSMPPKQSKPMKPLPQGHLDELTNKVFN 1250
            |:||..|::..||||:.:.       .|::|.|.|.    |.||:..:...|:.||         
Mouse  1084 PLDLGAPISSLDGQRVILEERDPSRGKVSTDKQKGA----PVKQNSAVNSSPRNHL--------- 1135

  Fly  1251 ELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSS 1315
                    |...|::..      |||..         ::|     |.|..:::.|:|.|:..|  
Mouse  1136 --------AMGEERTLG------KSNSI---------KIR-----GENGKSARDPRLSKREES-- 1170

  Fly  1316 QQSEEAATTQAVADPKKPIIAKL--KAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEIN 1378
                               |||:  |...|:.:.|     .:|..|.:.:||..|.:||||....
Mouse  1171 -------------------IAKIGKKKYQKINLDE-----AEEFFELISKAQSNRADDQRGLLRK 1211

  Fly  1379 FD--LPDFLKNKENLSAAVSKLRKVRASLSPV---SKVPAT---------PTEIPQPAPRLSITR 1429
            .|  ||:||:    |.|..|:|  ..:|..||   ||...|         ..|....:|..|...
Mouse  1212 EDLVLPEFLR----LPAGSSEL--ALSSPPPVKGYSKRAVTGHGQEGAAQTEESYSDSPATSPAS 1270

  Fly  1430 SQQPVSPMKVDQEPETDLPAATQDQTEFAKAP-PPLPPKPKVLPIKPSNWGVAQP-TGNYCNKYS 1492
            :|.|.|...         |.:..........| ||...:|...|.|||...:.|. |.....:.|
Mouse  1271 AQSPCSAYS---------PGSAHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGTTQAWRRLS 1326

  Fly  1493 PSKQ 1496
            |..:
Mouse  1327 PEME 1330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 39/75 (52%)
PTB_RGS12 251..391 CDD:269984 48/142 (34%)
RGS_R12-like 828..941 CDD:188661 58/114 (51%)
RGS12_RBD 1073..1145 CDD:176412 20/71 (28%)
RBD 1144..1213 CDD:128731 24/76 (32%)
Rgs12XP_006504183.1 PDZ_signaling 19..95 CDD:238492 39/75 (52%)
PTB_RGS12 227..358 CDD:269984 48/142 (34%)
RGS_RGS12 716..830 CDD:188696 58/114 (51%)
RGS12_us1 836..949 CDD:374670 30/130 (23%)
RBD1_RGS12 962..1031 CDD:340656 18/68 (26%)
Ubiquitin_like_fold 1032..1104 CDD:391949 25/71 (35%)
RGS12_us2 1106..1180 CDD:374668 26/135 (19%)
GoLoco 1189..1209 CDD:366965 9/19 (47%)
RGS12_usC 1238..1361 CDD:374669 22/102 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I5880
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1878
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49673
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006108
OrthoInspector 1 1.000 - - otm43409
orthoMCL 1 0.900 - - OOG6_106352
Panther 1 1.100 - - LDO PTHR45945
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R16841
SonicParanoid 1 1.000 - - X5044
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.950

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