DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Dlg5

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_017171686.1 Gene:Dlg5 / 71228 MGIID:1918478 Length:1931 Species:Mus musculus


Alignment Length:1372 Identity:241/1372 - (17%)
Similarity:413/1372 - (30%) Gaps:500/1372 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 RRRKKRANYNYNGIRTVEVRRGYNGFG-------FTISGQQPCR-------------LSCIISSS 100
            :::..:|..|..|...:.|||..:..|       ..:|||:..|             .:.::..|
Mouse   693 KKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKGSRPQDSGISLENGVYAAAVVPGS 757

  Fly   101 PAEQAG-LRSGDFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRG 164
            ||.:.| |..||.::::||:.:..........|:.:...|:.:.:.:.:...||        ..|
Mouse   758 PAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSS--------WSG 814

  Fly   165 QLLAASLRHKPRFL-----------HHKAKLHRLRNSPQKKLNPPEAVE---------------- 202
            |.:..:::...|.|           |:|..|.:..||.|..:...:.:|                
Mouse   815 QNIFENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLH 879

  Fly   203 -PHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEM--- 263
             |....|||..|...|...:..|.:..|..:.......:........|.....||..|.:|:   
Mouse   880 KPFSGSSSPVSPQACPSTSERSLNSFRSDTSAERGYGLVDMRSQRPLLSFETEVGPCGAVEVPLD 944

  Fly   264 -------------PKQISHSSKLQTVRSCIRKLRQEKR--------------------------- 288
                         ||.:..|:......|..:|.:|.|.                           
Mouse   945 KIDPEGSNSGGTWPKAVLGSTSGPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGLTH 1009

  Fly   289 --QPTIVLMCITP-------DSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNT 344
              ||:..:..:||       ||:..|               :.:.:|||||....|...|....:
Mouse  1010 SPQPSKRVGSLTPPKPPRRSDSIKFQ---------------HRLETSSESEATLVGSSPSTSPPS 1059

  Fly   345 QIEEEYEPSAGSAAA--------------------AGHISISHSCHVFVIDTKLIEHAQHLQR-- 387
            ......:||..:.|:                    ..::.....|...:...|:.|..|..:|  
Mouse  1060 APPPSMDPSEPTHASPPRKARVRIASSYHSEGDGDTSYLPAKKPCDEDLTSQKVDELGQKRRRPK 1124

  Fly   388 -AHEFRLQCTRDPISNLCLE----------------------------------FPNNSEYVVNL 417
             |..||.:.:...|...|||                                  :||... |..:
Mouse  1125 SAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHASRHGNPLLYPNRPS-VGTV 1188

  Fly   418 VRSM--------------YTM---RILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEI 465
            .|||              ||:   |:||..|.....|    ||:.:.        ||...:...:
Mouse  1189 PRSMTPGTTVGSILRNPIYTVRSHRVLPCGSPPVPRD----AGSQSL--------SPSVQHQGRL 1241

  Fly   466 STTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDN--- 527
            |...|        :..|::.|:               ..|..|..:.|:.||    :|...|   
Mouse  1242 SLDLS--------HRACSDYSE---------------MRASQGSNSLPSSAR----LGSSSNLQF 1279

  Fly   528 ---RLTVRAMP---------DHSALLRS----PPASSSLRRPNLLASFNLIQSPATNLTSTRSCD 576
               |:.:...|         |..:|..|    ||                 :|| .|:.:..|| 
Mouse  1280 KAERIKIPLTPRYPRSVMGSDRGSLSHSECSTPP-----------------RSP-LNIDTLSSC- 1325

  Fly   577 DVLNLFVDDSPRTLAAVASMDDISLHSAA--------PSLDEGHTFAHPACVPRKMRRSLALETP 633
                    ..|:|.|  :::..|:::.::        |.::|          ||.::    ::..
Mouse  1326 --------SQPQTTA--STLPRIAVNPSSHGERRKDRPFVEE----------PRHVK----VQKG 1366

  Fly   634 TTPHKLSAQVFGQPGS-----------RHSLGFEAID-----------SVQSSVSGACMDQTMDT 676
            :.|..:|. |.|:.|.           .|..|.|..|           |.....:...:.|..||
Mouse  1367 SEPLGISI-VSGEKGGVYVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDT 1430

  Fly   677 WASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKV 741
            ...|.. :..|..:.:..:.||||                |...|:|.....| ||..||....|
Mouse  1431 ITILAQ-YNPHIHQLNSHSRSSSH----------------LDPAATPHSTLQG-SSAGTPEHPSV 1477

  Fly   742 ---AKEQQQLGQSSPVRRTASMNASDND----------MYIKTLMLDSDLK-SSRSQHQLSLLQV 792
               ..||.:...:.|.:::||...|..|          ::||...||..:. ...:.|.:.:.:|
Mouse  1478 IDPLMEQDEGPGTPPAKQSASSTRSVGDTTKKTPDPRIVFIKKSQLDLGVHLCGGNLHGVFVAEV 1542

  Fly   793 PKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFS------A 851
            ........|...:...:..|..:.|.. ..:....:..||:....::...::..:||:      .
Mouse  1543 EDDSPAKGPDGLVPGDLILEYGSLDMR-SRTVEDVYVEMLKPKDSLRLKVQYRHEEFTRVKGLPG 1606

  Fly   852 ENIYF-----------------------------------WTACERYRLLESEADRVAQAREIFA 881
            ::.|.                                   |.|.:    |:..|.:: |..:|.:
Mouse  1607 DSFYIRALYDRLAEVEPELSFKKDDILYVDDTLPQGVFGSWMAWQ----LDENAQKI-QRGQIPS 1666

  Fly   882 KHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIF---------------SLMKFD--- 928
            |::.:...      |:..|::|.|..:.|..:.|.|::..|               .|:..|   
Mouse  1667 KYVMDQEF------SRRLSMSEVKDDNTAKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDTFS 1725

  Fly   929 -------------SYQRFIRSDLYKSCVEAEQKNQPLPYSG--LDLDELLKTNFHLGAFSK---- 974
                         :|||..:.|    |...    :|:...|  ||:.:.:..|...|.|.:    
Mouse  1726 NDSIPLFEDSVSLAYQRVQKVD----CTSL----RPVLLLGPLLDVVKEMLVNEAPGKFCRCPLE 1782

  Fly   975 LKKSASNAEDRRRKSLLPWHRKTRSKSRDRT------EIMADMQHALMPAPP-----------VP 1022
            :.|::..|.:|..|..|....|.||...|.|      ||....:|.|:...|           .|
Mouse  1783 VMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYP 1847

  Fly  1023 QNAPLTSASLKLVCGQNS---LSDLHSSRSSLSSFD-------------AGTATGGQGASTESVY 1071
            ....:...|.|.:..|..   |.|..:.|.|...|:             .|...||      ::.
Mouse  1848 IVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSKEQFETAQKIDQEYSRYFTGVVQGG------ALS 1906

  Fly  1072 SLCRVIL 1078
            |:|..||
Mouse  1907 SICTQIL 1913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 19/96 (20%)
PTB_RGS12 251..391 CDD:269984 34/214 (16%)
RGS_R12-like 828..941 CDD:188661 26/184 (14%)
RGS12_RBD 1073..1145 CDD:176412 3/6 (50%)
RBD 1144..1213 CDD:128731
Dlg5XP_017171686.1 Takusan 129..213 CDD:368141
Smc <141..564 CDD:224117
PDZ_signaling 625..712 CDD:238492 3/18 (17%)
PDZ_signaling <741..800 CDD:238492 11/58 (19%)
PDZ 1357..1439 CDD:214570 17/97 (18%)
dbPDZ_assoc 1437..1512 CDD:374667 21/91 (23%)
PDZ 1513..1594 CDD:214570 11/81 (14%)
SH3_DLG5 1610..1672 CDD:212794 8/66 (12%)
GuKc 1744..1920 CDD:214504 40/184 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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