DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Pdzd2

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	2115	Identity:	382/2115 - (18%)
Similarity:	628/2115 - (29%)	Gaps:	813/2115 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GTGAAA-------AEDASPAANSGPAPISTSTTPSGSNSQQHQRRR--------KKRANYN---- 65
            |||:||       :|::....:|..:..:...:|...||:...:.|        :....||
Mouse   461 GTGSAAVRGTMLGSEESQDVGSSEESKGNNLESPKQGNSKMKLKSRLSGGVHRLESVEEYNELMV 525

  Fly    66 YNG---IRTVEVRRG------------------YN------------------------------ 79
            .||   ||.:||.|.                  |:
Mouse   526 RNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISIIG 590

  Fly    80 -------GFGFTISGQQPC---RLSCII-----SSSPAEQAGLRSGDFLISVNGLNVSKLPHETV 129
                   |.||:|:|.:.|   ::...:     :.|.||...|:.||.::.|||:.:..|..:..
Mouse   591 LYKEKGKGLGFSIAGGRDCVRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 655

  Fly   130 VQLIGNSFGSIRMQI------------------AENYYSDSS---------------DEENAHAT 161
            :    ::|..||..:                  ...:.|.||               .:|...|:
Mouse   656 I----HTFKQIRSGLFVLTVRTKLLSPSLTPCSTPTHMSRSSSPSFNSSGGAPAGGGQDEGGSAS 716

  Fly   162 LRGQ--------LLAASLRHKPR-------------------FLH-------------------- 179
            |..:        ::..:|..:||                   ::|
Mouse   717 LGRKAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQI 781

  Fly   180 ---------HKA--KLHRLRNS-------------PQKKLNPPEAVEP------HKSKSSPDHPT 214
                     |.|  |:|.:.:.             |..|::..|..|.      .:||.:...|:
Mouse   782 LEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPS 846

  Fly   215 LKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVG-----YLGTIEMPKQISHSSKLQ 274
            |...|:.|.|....|..:: :.:|......|..:|...|:.|     :.|:   ..:.|....|.
Mouse   847 LGTPLKSPSLAKKDSLLSE-SELSQYFVHDGQGSLSDFVVAGSEDEDHPGS---GYETSEDGSLL 907

  Fly   275 TVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSE----------- 328
            ||.|..|:..:.:....:        :|..|..||.:....:.||...:..|.:
Mouse   908 TVPSAYRETGKARANSLV--------TLGSQRGSGLLHKQVTVARQASLPGSPQVLRNPLLRQRR 964

  Fly   329 ------------------------------------SENRFFGLVTSAVH---NTQIEEEYEPSA 354
                                                .::..|.|.||:..   |.|.|...:|
Mouse   965 VRCYDSNDGSDDEDFDGEGDCVSLPGVLPGPGRPLVQDDTRFALATSSKSIDVNKQDERLQKP-- 1027

  Fly   355 GSAAAAGHISISHSCHVFVIDTKL-IEHAQHLQRAH----------------------------- 389
                     .:|.:|.|.::.:.| .||:.|...|.
Mouse  1028 ---------LVSKACSVPLLGSSLDSEHSIHGGTAGTPPKAASLPGSVETPKNGPGGSRRKEMSG 1083

  Fly   390 -------EFRLQC-TRDPISNLCLEFPNNS----EYVVNLV-RSMYTMRILPPASRS--HQADYE 439
                   |:|:.. |:.|.|      |.|.    :...||| |.....||.|...||  .:|..|
Mouse  1084 SRSSPKLEYRVPADTQSPRS------PENGTSPPQKTENLVSRHKPVARISPHYKRSDAEEAPSE 1142

  Fly   440 AGAGAAAAGGAV--------AAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLA 496
            ...|..|....|        .|.|.|..:...|:....:..||.:..|  |...|........|.
Mouse  1143 TANGPCAQDLKVQASSVKDPVAGHQPGGTAEKELRGNPTPGDSSVPTN--CGPASTPCHPNTGLP 1205

  Fly   497 AGAGAAAAAHAGP------------PTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSS 549
            ......||...||            |..|..:|              ...||.|   .:|..:..
Mouse  1206 TENPQGAAPECGPHPGTGWDGSSDHPPSPGKSR--------------EVRPDSS---ETPAVTEQ 1253

  Fly   550 LRRPNLLASFNLIQSPATNLTSTRSCDDVLNL---------------FVDDSPRTLAAVASMDDI 599
            :.:|..|:      .|.:..||......|..:               .:.||.||.|........
Mouse  1254 VLQPESLS------QPVSPGTSEPESQGVSKMKPASQRSLSPREKASALPDSSRTWAGPGDSTPS 1312

  Fly   600 SLHSAAP-SLDEGHTFA--HPA----------------------CVPRKMR-RSLALETPTTPHK 638
            :..:|.| |:.|....|  ||:                      |||..:: |:|..||.:...|
Mouse  1313 TRRAAVPMSIGETRATAIPHPSLLGQERSRDPSGPSKALETPGHCVPTSLKDRALLEETASASGK 1377

  Fly   639 LSAQVFGQPGSRHSLGFEAIDSVQSSVSGAC----------MDQTMDTWASLQNLH---KSHKD- 689
            ||          |: |.....:...::||:.          :.:..:.|.|.....   ::|:|
Mouse  1378 LS----------HA-GPSVPVTTDGTLSGSTESPVTDIDKFIGEAPEAWLSQSPQRADCRTHQDI 1431

  Fly   690 -----RTSMSASSSSHCLLEATNSEPDLGNRALPA---NASPFRRAWGQSSFRTPRSDKVAKEQQ 746
                 .......||.|.....|.|.|.......|:   :..|.::..|..:|....|...:...:
Mouse  1432 FESQPPGGAGGGSSHHGKTGGTGSPPPPQWTFQPSVLDSVHPDKQLAGNKNFLNNYSRNFSSFHE 1496

  Fly   747 QLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTT---PAPPSAITAS 808
            . |.|.|         |.:.||       .|.:.|.|..: ||::.|:....   |||||..::.
Mouse  1497 D-GVSEP---------SPSSMY-------GDAEDSSSDPE-SLVEDPRAAARNNWPAPPSHESSR 1543

  Fly   809 VAAEGAAQDH--------GC---------PSSWAG----SFERMLQDAAG--------------- 837
            ......::|.        ||         |:..||    |.::.:::..|
Mouse  1544 KEGSSESEDEQIEICAPGGCPETPVPAQAPAQAAGGAVPSVQQTVREPVGDACEKACFMTGASNT 1608

  Fly   838 -----MQTFSEFLKKEFSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQ 897
                 .|.|| ||  :.|:.....|...:..|   |.....|:      :.||.:|:..|..|||
Mouse  1609 CIPGSSQPFS-FL--DVSSLEHETWAGVQTSR---SHMPGCAE------ETLAVSSTGSVVGDSQ 1661

  Fly   898 --------------------ARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSC 942
                                ...|.::.|.:..||..|.|.              .:.|.:|...
Mouse  1662 PSQTTRPCGNPPFVLRNPDMVNGLGQDLLDEGTPDKGADAS--------------HVMSSVYALG 1712

  Fly   943 VEAEQKNQPLPYS-----GLDLDELL---KTNFH---LGAFSKLKKSASNA-----EDRRRKSLL 991
            .|..:..:.:..:     |.:||.||   ||...   :..|..:.|.:..|     .::.:.|:|
Mouse  1713 AEGPKNGEAVLANLHIAKGGNLDGLLQKPKTTSRRPIMTWFKDINKDSQGAHLQSKSEKEQPSML 1777

  Fly   992 ------------PWHRK---------TRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLV 1035
                        |.|||         .|.||::..:        |.|..||.     |.::.:..
Mouse  1778 AMSPGSKGNTVNPSHRKGMAVPKSPPPRQKSQENKD--------LSPKSPVE-----TLSNCQKP 1829

  Fly  1036 CGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSL---------------CRVILTDGATTI 1085
            .|...|..|:|  .|.:|.:|..|:..:|..|:...||               .|:.:.|
Mouse  1830 KGSPKLKRLNS--KSKASPEAPVASPAKGGRTDHRKSLPSPQAAHKMLSKAVSHRLHIAD----- 1887

  Fly  1086 VQTRPGETVGELVERLLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLP 1150
             |..|..|.|                            |..:|.|.:...:..:....:.:....
Mouse  1888 -QEEPKNTAG----------------------------DTSKPPQCVPESKPPLAASGSLRTSAS 1923

  Fly  1151 DPKVISVKS---KPKKQLHEVIRPILSK-YNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIV 1211
            |..:.::.|   .||        |:..: .|.:......:..||..|.....|....:|   ::.
Mouse  1924 DTSIRTITSPLTSPK--------PLPEQGANNRFHMAVYLESDTSCPATSRPPRYGPEG---KVP 1977

  Fly  1212 MVNSDFQVGGGSSMPP-----------KQSKPM-----------KPLPQGHLDELTNKVFNELLA 1254
            ..||      ||..|.           :|||..           ...|||..::.|.|:.::.|
Mouse  1978 HANS------GSVSPSASRTNIALAGVRQSKQFTHSRVDLVLTEAAQPQGISEKGTEKMASDPL- 2035

  Fly  1255 SKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSE 1319
                    |::..:.:..:.|...|.....  ::.....|.||.:..|   ..::||:...:||.
Mouse  2036 --------ERTNQLKIIEISSERMPKNACG--DKPPGSDRKGGFLTQS---NCQEKSSVRLRQSA 2087

  Fly  1320 EAATTQAVADPKKPIIAKLKAGVKLQVTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDF 1384
            |::       ||:|.....:|          ::.:.|:......|:||. ......::...:||:
Mouse  2088 ESS-------PKQPHFPPSQA----------SQGEQEMRWSYSMARLAS-SSPSAPQLPSKMPDY 2134

  Fly  1385 LKNKENLSAAVSKLRKVRASLS-PVSKVPA------TPTEIPQPAPRLSITRSQ----------Q 1432
            .:.|.:         ::.||:. |.:.||.      .|...|:||.|.....:|          .
Mouse  2135 SQGKSS---------QMPASVGVPKNGVPVGLAGEEPPYFTPRPATRTYSMPAQFSSHFGREGLS 2190

  Fly  1433 PVSPMKVDQEP----------ETDLPAATQDQ--------TEFAKAPPP--------LPPKPKVL 1471
            |.||....|:|          |......|.:|        .|..:.|||        :|....::
Mouse  2191 PPSPSHSPQDPQVTAMSGSLSEKSAKGVTNEQGVYSVKPLLETLRNPPPVDVGDVSAVPEASGLI 2255

  Fly  1472 PIK----------PSNW--------GVAQ---PTGNYCNKYSPSKQVPTSP--KEASKP------ 1507
            |.|          ..:|        .|.|   ...|..|...|:.:..|||  ..:|||
Mouse  2256 PDKLKVTRRHYYCEQSWPHESTSFFSVKQRIKSFENLANSDRPAAKSATSPFLSVSSKPPVNRRS 2320

  Fly  1508 -GTFASKIPLDLGRKSLEEAGSRCAYLDEPSSSFV 1541
             |:..|..|.|...:||..:.|.|:.....:||.:
Mouse  2321 SGSITSGRPSDGTARSLRRSLSSCSENQSEASSLL 2355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	25/156 (16%)
		PTB_RGS12	251..391	CDD:269984	32/231 (14%)
		RGS_R12-like	828..941	CDD:188661	26/152 (17%)
		RGS12_RBD	1073..1145	CDD:176412	10/86 (12%)
		RBD	1144..1213	CDD:128731	11/72 (15%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492	19/84 (23%)
		PDZ_signaling	729..813	CDD:238492	8/83 (10%)
		PHA03307	1050..>1355	CDD:223039	61/335 (18%)
		PHA03247	<1197..1562	CDD:223021	77/416 (19%)
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900