DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and Pdzd2

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_038959013.1 Gene:Pdzd2 / 65034 RGDID:619958 Length:2818 Species:Rattus norvegicus


Alignment Length:1961 Identity:365/1961 - (18%)
Similarity:589/1961 - (30%) Gaps:703/1961 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 TAVGTGAAAAEDASPA--ANSGPAPISTSTTPSGSNSQQHQRRRKKRANYNYNGIRTV------- 72
            |...|....:..:||:  .|||..|........||:|...:....|.        |.|       
  Rat   680 TPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGSSSLGRKAPGPKD--------RIVMEVTLNK 736

  Fly    73 EVRRGYNGFGFTISGQQPCRLSC--------IISSSPAEQAGLRS----GDFLISVNGLNV---- 121
            |.|.|. |.|       .|.|:.        |.|.:|...|.:.|    ||.::.||.:||    
  Rat   737 EPRVGL-GIG-------ACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAA 793

  Fly   122 --------SKLPHETVVQLIGN------SFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLR 172
                    ||.|...|..:||.      |...:...||.:.|.:|. |.|:...|...|.:.||.
  Rat   794 LSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESR-EANSSPGLGTPLKSPSLA 857

  Fly   173 HKPR----------FLH--------------------------------------HKAK------ 183
            .|..          |:|                                      |||:      
  Rat   858 KKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLPVPSAHKARANSLVT 922

  Fly   184 ---------LHR---------LRNSPQKKLNP---PEAVEPHKSKSSPDHPTL------------ 215
                     ||:         |..|||...||   ...|..:.|....|....            
  Rat   923 LGSQRTSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSNGGSDDEDFDGEGDCISLPGV 987

  Fly   216 -----KPVLED---PPLTANLSKAADV-----------ANVSAMVRAVGSAA-LECRVIVGYLGT 260
                 ||::||   |.||.: ||:.||           .:.:..|..:||:. .|..::.|..||
  Rat   988 LPGPGKPLVEDDTRPALTTS-SKSIDVNKQEERLQKPLVSKACSVPLLGSSLDSEHSILNGTGGT 1051

  Fly   261 I----------EMPKQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATY 315
            .          |.||.....|..:.:.......:.|.|.||        |:.|.:|..       
  Rat  1052 PPKVASLPGSGETPKNGPRGSGRKEMSGSRSSPKLEYRVPT--------DTQSPRSPE------- 1101

  Fly   316 SSARLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIE 380
                 |..|...:|||    ||:......:|...|:.|....|..|  :.:..|           
  Rat  1102 -----NHTSPPQKSEN----LVSRHKPVARISPHYKRSDAEEAPGG--TANGPC----------- 1144

  Fly   381 HAQHLQRAHEFRLQCT--RDPIS--------------NLCLEFPNNSEYVVNLVRSMYTMRILPP 429
                   |.:.::|.:  :||::              |   ..|.:|....|..         |.
  Rat  1145 -------AQDLKVQASPVKDPVTGRQPGGTAEKELQGN---PTPGDSSVPTNCG---------PA 1190

  Fly   430 ASRSHQ---ADYEAGAGAA-------AAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTN 484
            ::..|.   ...|...|||       ..|...::.|...|....|:...:|.:.:          
  Rat  1191 STPCHPNTGLPTENPQGAAPECVPHPGTGWDGSSEHLCSPGKSREVHPDSSETPT---------- 1245

  Fly   485 ISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSS 549
                            .|...|. |.:...|..|.            .:.|:...:.:..|.|..
  Rat  1246 ----------------VAEQVHQ-PESLSQPVSPR------------TSEPESQGISKMKPPSQR 1281

  Fly   550 LRRPNLLA-----SFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASM--DDISLHSAAPS 607
            ...|...|     |.....:|..:..|||..  .:.:....:|.|....||:  .:.|...:.||
  Rat  1282 CVSPREKASTPPDSSRAWAAPGDSSPSTRRI--AVPMSTGAAPATAIPQASLVSQERSRGLSGPS 1344

  Fly   608 LDEGHTFAHPACVPRKMRRSLALE-TPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMD 671
            ...|   ....|:|:.::....|| |.....|:|          |:.......:.:.::||:..:
  Rat  1345 KGLG---TKELCIPKSLKDGALLEDTAPASGKMS----------HASSPSGPVATERTLSGSPEN 1396

  Fly   672 QTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTP 736
            ...|....::...::...::...|...:|.  :...|:|..|     |.:|....|      :..
  Rat  1397 PVTDIDNFIEEASEARLSQSPQKADCRAHG--DTFESQPPGG-----AGSSSSHHA------QMV 1448

  Fly   737 RSDKVAKEQQQLGQSSPVRRTASMNAS-------DNDMYIKTLMLDSDLKSSRSQHQLSL-LQVP 793
            |||:.:..::..|..||..:..::..|       |..:.:....|::..::..:.|:.|: |..|
  Rat  1449 RSDQTSSPRKTGGTGSPPPQQWALQPSVLDSIHPDKHLAVNKTFLNNYSRNFSNFHEDSISLSGP 1513

  Fly   794 KVLTTPAPPS----AITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENI 854
            ...:.|:|.|    |..:|...|..|:|.|               ||....:|..|..|.|.:. 
  Rat  1514 GGSSEPSPSSMYGNAEDSSSDPESLAEDPG---------------AAARNNWSPPLSPESSPKE- 1562

  Fly   855 YFWTACERYRLLESEADRVAQAREIFAKHLANNSSD-----PVNVDSQARSLTEEKLADAAP--- 911
                     ...|||.:|:    ||.       |:|     ||.    |...|:..|....|   
  Rat  1563 ---------GSSESEDERI----EIC-------STDGCPGTPVT----APPPTQVALCPVLPVQQ 1603

  Fly   912 --------DI-----FAPA--------QKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYS 955
                    ||     |.|.        ..|.||.:...|.:    .:.:.| :.|.|.:.|:...
  Rat  1604 RAVCKPVGDICERACFVPGASRTSIPDSSQPFSFLDVSSEE----PETWAS-INASQNHMPVCTE 1663

  Fly   956 GLDLDELLKTNFHLGAFSKLKKSASNAEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPP 1020
            |: :|              :..::||..| .:.|.:..|.:.........:::.|:...|:    
  Rat  1664 GI-MD--------------VTSTSSNMGD-SQSSQMTRHCRNAPFVLGNPDMVNDLGRDLL---- 1708

  Fly  1021 VPQNAPLTSASLKLVC-------------GQNSLSDLH-----------------SSRSSLSSFD 1055
             .:.||...|:...|.             |:..|:|||                 |.|..|:.|.
  Rat  1709 -DEGAPKEGAAAASVMRSVFALGAEGPKNGEAVLADLHIAERGNLEDLLQKPKTISRRPILTWFK 1772

  Fly  1056 A--GTATGGQGASTESVYSLCRVILTDGA-TTIVQT---------------------------RP 1090
            .  ..:.|....||........:.|..|: ..:|.|                           .|
  Rat  1773 EINKDSQGSHLRSTSEKEQSSMLALGPGSKANMVNTGHRKGVTVPKSPPSRQKSQENKDLPPKSP 1837

  Fly  1091 GETVGELVE-------RLLEKRNLVYPYYDIVF--QGS----TKSIDVQQPSQILAGKEVVIERR 1142
            .||:|...:       :.|..:....|...:..  :||    .|::...|.|..:..|.|.....
  Rat  1838 VETLGNCQKPKCSPKLKRLNSKGKASPEVPVAISTKGSRNDHRKTLPSPQASHKMFSKAVSHRLH 1902

  Fly  1143 VAFKL-------DLPDPKVISVKSKPKK-------------QLHEVIRPILSK-------YNYKM 1180
            :|.:.       |.|.|.....:|||.:             .:.....|:.|.       .|.:.
  Rat  1903 IADQEEPKNTAGDTPKPPQCVPESKPPQAALGSLRTSASDTSIRTFTSPLTSPKLLPEQGANSRF 1967

  Fly  1181 EQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPP-----------KQSKPMK 1234
            .....:..||..|.....|.:..:|   :....||      ||:.||           :|||...
  Rat  1968 HMAVYLESDTSCPTTSRSPRSGPEG---KAPHANS------GSASPPASRASLALAGIRQSKQFT 2023

  Fly  1235 PLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLC----SMKSNEAPSETSSL---------- 1285
            |                   .:||...||.::|..:|    ..|.::.|..|:.|          
  Rat  2024 P-------------------GRADLLVSEATQPQGICEKGAEKKVSDPPQRTNQLKIVEISSERV 2069

  Fly  1286 -----FERMRRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIAKLKAGVKLQ 1345
                 .:|.....|.||.:..:   ..::||....:||||::.......|               
  Rat  2070 PKNACGDRPPESDRKGGFLTQN---NCQEKSAIRLRQSEESSPEHTPFPP--------------- 2116

  Fly  1346 VTERVAEHQDELLEGLKRAQLARLEDQRGTEINFDLPDFLKNKENLSAAVSKLRKVRASLS-PVS 1409
              .:.::.:.|:......|:.| .......::...||:..:.|.:         ::.||:. |.:
  Rat  2117 --SQASQVEREIRWSFSMAKPA-TSSSSSLQLPAKLPESFQGKSS---------QMPASVGVPKN 2169

  Fly  1410 KVP------ATPTEIPQPAPRLSITRSQ----------QPVSPMKVDQEPETDLPA--------- 1449
            .||      .:|...|:||.|.....:|          .|.||....|:|:  :||         
  Rat  2170 GVPIGLAGEESPYFTPRPATRTYSMPAQFSSHFGREGPSPHSPSHSPQDPQ--VPAMGGKLSEKT 2232

  Fly  1450 ---ATQDQTEFAKAP-------------------PP----LPPKPKVL----------PIKPSN- 1477
               .|..|..::..|                   |.    :|.|.||.          |.:.:: 
  Rat  2233 AKGVTNGQGVYSVKPLLETSKNLSPVDGRDVSADPETSCLIPDKVKVTRRQYCCEQSWPHESTSF 2297

  Fly  1478 WGVAQ---PTGNYCNKYSPSKQVPTSP--KEASKP-------GTFASKIPLDLGRKSLEEAGSRC 1530
            :.|.|   ...|..|...|:.:..|||  ..:|||       |:..|..|.|:..:||..:.|.|
  Rat  2298 FSVKQRIKSFENLANSDRPTAKCATSPFLSVSSKPPINRRSSGSIPSGSPSDMTSRSLRRSLSSC 2362

  Fly  1531 AYLDEPSSSFV 1541
            :.....:||.:
  Rat  2363 SESQSEASSLL 2373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 27/112 (24%)
PTB_RGS12 251..391 CDD:269984 28/149 (19%)
RGS_R12-like 828..941 CDD:188661 28/141 (20%)
RGS12_RBD 1073..1145 CDD:176412 17/112 (15%)
RBD 1144..1213 CDD:128731 15/95 (16%)
Pdzd2XP_038959013.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 590..671 CDD:238492
PDZ_signaling 729..813 CDD:238492 23/91 (25%)
PHA03247 <985..1446 CDD:223021 103/584 (18%)
PDZ_signaling 2603..2677 CDD:238492
PDZ_signaling 2731..2813 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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