DRSC/TRiP Functional Genomics Resources

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Protein Alignment loco and RGS10

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:NP_001005339.1 Gene:RGS10 / 6001 HGNCID:9992 Length:181 Species:Homo sapiens


Alignment Length:159 Identity:63/159 - (39%)
Similarity:97/159 - (61%) Gaps:2/159 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly   796 LTTPAPPSAITASVAAEGAA-QDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTA 859
            |:...|||.|..|..:..:: |.....:.||.|.|.:|:|..|::.|.||||||||.||:.||.|
Human     9 LSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLA 73

  Fly   860 CERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSL 924
            ||.::.::.:.....:|:||:...|::.:|..|||:.|:| |.|:.|.:..|.:|...|.|||:|
Human    74 CEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSR-LNEKILEEPHPLMFQKLQDQIFNL 137

  Fly   925 MKFDSYQRFIRSDLYKSCVEAEQKNQPLP 953
            ||:|||.||::|||:......|::.:.||
Human   138 MKYDSYSRFLKSDLFLKHKRTEEEEEDLP 166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492
PTB_RGS12 251..391 CDD:269984
RGS_R12-like 828..941 CDD:188661 50/112 (45%)
RGS12_RBD 1073..1145 CDD:176412
RBD 1144..1213 CDD:128731
RGS10NP_001005339.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 7/22 (32%)
RGS_RGS10 42..154 CDD:188695 50/112 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 158..181 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160275
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3589
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D144440at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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