DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and RGS3

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_652759.4	Gene:	RGS3 / 5998	HGNCID:	9999	Length:	1094	Species:	Homo sapiens

Alignment Length:	1060	Identity:	229/1060 - (21%)
Similarity:	355/1060 - (33%)	Gaps:	301/1060 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PSGSNSQQHQRRRKKRANYNYNGIRTVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSG 110
            |.|.:::..::.:             :.:.||.:||||||....|.|:..:.|..|||:|||:..
Human   183 PGGGDTENGKKLK-------------ITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQL 234

  Fly   111 DFLISVNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKP 175
            |.::.   ||...:.|...|:                                       |.|:.
Human   235 DTVLQ---LNERPVEHWKCVE---------------------------------------LAHEI 257

  Fly   176 RFLHHKAKLHRLRNSPQKKLNPPEAVEPHKS-KSSPDHPTLKPVLEDPPLTANLSKAADVANVSA 239
            |....:..|...|..||.|..|...|....| ||:.|       |:.||   |..:......|.|
Human   258 RSCPSEIILLVWRMVPQVKPGPDGGVLRRASCKSTHD-------LQSPP---NKREKNCTHGVQA 312

  Fly   240 MVRAVGSAALECRVIVG-YLGTIEMPKQISHSSKLQTVRSCIRKLRQEKRQPT----IVLMCITP 299
            ......|..|.|....| .||..|...:::......|:.:..|     ...||    |:|..:.|
Human   313 RPEQRHSCHLVCDSSDGLLLGGWERYTEVAKRGGQHTLPALSR-----ATAPTDPNYIILAPLNP 372

  Fly   300 DSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGL-----VTSAVHNTQIEEEYE------PS 353
            .|..|:       ..|....:...|.|......:.||     :...|...:....|:      |.
Human   373 GSQLLR-------PVYQEDTIPEESGSPSKGKSYTGLGKKSRLMKTVQTMKGHGNYQNCPVVRPH 430

  Fly   354 AGSAAAAGHISISHSC---HVFVIDTKLIEHAQHLQRAHEF------------------------ 391
            |..::...:::::...   .|||....|...|:.|..:.|.
Human   431 ATHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKAAEVTLFAYSDLLLFT 495

  Fly   392 ------RLQCTRDPISNLCLEFPNNSE--------YVVNLVRSMYTM---------RIL------ 427
                  |....|:|:....::....|.        |:......::|:         |:.
Human   496 KEDEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSEN 560

  Fly   428 ----------PPASRSHQAD--------YEAGAGAAAAGGAVAAAHSPQPSNHSEI---STTTSN 471
                      ||.|:..:.:        .|.|.|.    ||..:..|.:||...|:   .....|
Human   561 IAKQQQLAASPPDSKMFETEADEKREMALEEGKGP----GAEDSPPSKEPSPGQELPPGQDLPPN 621

  Fly   472 SDSGIGFNNDCTNISDRILVVDFLAA-----GAGAAAAAHAGPPTYPAPAR--------PLGIVG 523
            .||..|  .:.....:.:...|...:     |..|..:....|...|.||:        |.|...
Human   622 KDSPSG--QEPAPSQEPLSSKDSATSEGSPPGPDAPPSKDVPPCQEPPPAQDLSPCQDLPAGQEP 684

  Fly   524 IP--DNRLT----------VRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLT-STRSC 575
            :|  |..||          .|.:|....|   ||:..||              ||..|| .|.|.
Human   685 LPHQDPLLTKDLPAIQESPTRDLPPCQDL---PPSQVSL--------------PAKALTEDTMSS 732

  Fly   576 DDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKLS 640
            .|:| ....|.|                |||         .||.|..::|    |:: |...|..
Human   733 GDLL-AATGDPP----------------AAP---------RPAFVIPEVR----LDS-TYSQKAG 766

  Fly   641 AQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNL-HKSHKDRTSMSASSSSHCLLE 704
            |:. |..|.....  |..:.|:....|. .|:..||  |..|. .:|...|:||..:..
Human   767 AEQ-GCSGDEEDA--EEAEEVEEGEEGE-EDEDEDT--SDDNYGERSEAKRSSMIETGQ------ 819

  Fly   705 ATNSEPDLGNRALPANASPFRRAWGQSS-FRTPRSDKVAKE-----------QQQLGQSSPVRRT 757
              .:|   |..:|....|..||...:.| .:.||....|.:           ....|..||....
Human   820 --GAE---GGLSLRVQNSLRRRTHSEGSLLQEPRGPCFASDTTLHCSDGEGAASTWGMPSPSTLK 879

  Fly   758 ASMNASDNDMYIKTLM------------LDSDLKSSRSQHQLSLLQVPKVL--------TTPAPP 802
            ..:..:...|:..:|.            :..|.::||.:...:|.:..|..        .:|..|
Human   880 KELGRNGGSMHHLSLFFTGHRKMSGADTVGDDDEASRKRKSKNLAKDMKNKLGIFRRRNESPGAP 944

  Fly   803 SAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLE 867
            .|..|....:...........|..|.|::|....|:..|..||:.|||.||:.||.|||.::.::
Human   945 PAGKADKMMKSFKPTSEEALKWGESLEKLLVHKYGLAVFQAFLRTEFSEENLEFWLACEDFKKVK 1009

  Fly   868 SEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQR 932
            |::...::|::|||:::|..:...||:||..|..|::.|.......|..|||:||.||:.|||.|
Human  1010 SQSKMASKAKKIFAEYIAIQACKEVNLDSYTREHTKDNLQSVTRGCFDLAQKRIFGLMEKDSYPR 1074

  Fly   933 FIRSDLYKSCVEAEQKNQPL 952
            |:|||||...:..::.:.||
Human  1075 FLRSDLYLDLINQKKMSPPL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	22/75 (29%)
		PTB_RGS12	251..391	CDD:269984	29/158 (18%)
		RGS_R12-like	828..941	CDD:188661	47/112 (42%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
RGS3	NP_652759.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810