DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Slc9a3r1

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_067605.1	Gene:	Slc9a3r1 / 59114	RGDID:	708538	Length:	356	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	93/433 - (21%)
Similarity:	153/433 - (35%)	Gaps:	154/433 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VRRGYNGFGFTISGQ-----QPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLI 133
            :.:|.||:||.:.|:     |..||  :...||||::||.:||.|:.|||.||.|..|:.||..|
  Rat    17 LEKGPNGYGFHLHGEKGKVGQFIRL--VEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRI 79

  Fly   134 GNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLHRLRNSPQKKLNPP 198
            ..:..::|:.:.:    ..:||:                                   .|||..|
  Rat    80 RAALNAVRLLVVD----PETDEQ-----------------------------------LKKLGVP 105

  Fly   199 EAVEPHKSKSSPDHPTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEM 263
            ...|..:::...:|       .:||..|:..||.|                            :.
  Rat   106 IREELLRAQEKSEH-------TEPPAAADTKKAGD----------------------------QN 135

  Fly   264 PKQISHSSKLQ-TVRSCIRK---------LRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSA 318
            ..:.||..:.: ..|.|..|         |..:|.:|...:..:.|||   .:.:.|:.|.....
  Rat   136 EAEKSHLERCELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDS---PAEASGLRAQDRIV 197

  Fly   319 RLNFVSSSSESENRFFGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQ 383
            .:|.|.    .|.:..|.|.||:           .||...|          .:.|:|
  Rat   198 EVNGVC----MEGKQHGDVVSAI-----------KAGGDEA----------KLLVVD-------- 229

  Fly   384 HLQRAHEFRLQC------------TRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQA 436
              :...||..:|            ..:|.||..::..|:.|.:|.            |||.|.:.
  Rat   230 --KETDEFFKKCRVTPSQEHLDGPLPEPFSNGEIQKENSREALVE------------PASESPRP 280

  Fly   437 DYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTSNSDSGIGFN 479
            .. |.:.::.....:.|..||:..:.:|.|:|:|:||..:.||
  Rat   281 AL-ARSASSDTSEELNAQDSPKRHDSTEPSSTSSSSDPILDFN 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	29/75 (39%)
		PTB_RGS12	251..391	CDD:269984	25/149 (17%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Slc9a3r1	NP_067605.1	PDZ_signaling	12..91	CDD:238492	29/75 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		8/63 (13%)
		PDZ_signaling	149..228	CDD:238492	21/106 (20%)
		EBP50_C	232..356	CDD:286142	25/104 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..356		19/71 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900