Protein Alignment loco and axin1

DIOPT Version :10

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: XP_009297983.1
• Gene: axin1 / 57931
• ZFINID: ZDB-GENE-000403-1
• Length: 871
• Species: Danio rerio
• Alignment Length: 892
• Identity: 176/892 - (19%)
• Similarity: 296/892 - (33%)
• Gaps: 284/892 - (31%)

  Fly   692 SMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFR--TPRSDKVAKEQQQLGQSSPV 754
            |||.:....|.|      ||||                 |||.  .|| ..|..|:..|..|...
Zfish     2 SMSVNEKGICYL------PDLG-----------------SSFTEDAPR-PPVPGEEGDLVSSDGR 42

  Fly   755 RRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHG 819
            :...|..:|.:|    :|..::.:.:.| :..|.|...|:...:|.||..
Zfish    43 QYNHSFYSSKSD----SLKNEASIATPR-RPDLDLGYEPEGSASPTPPYL--------------- 87

  Fly   820 CPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERYRLLES---EADRVAQAREIFA 881
               .||.|...:|.|..|:..|..|||:|..|:.:.||.||..:|..|:   ....:..|:.|:.
Zfish    88 ---KWAESLHSLLDDQDGIHLFRTFLKQEECADMLDFWFACSGFRKQEANDGNEKMLKLAKAIYK 149

  Fly   882 KHLANNSSDPVNVDSQARSLTEEKLADAA------PDIFAPAQKQIFSLMKFDSYQRFIRSDLY- 939
            |::.:|:.   .|..|.:..|:..:.|..      |.:|..||.:|.::|:.::|..|::||:|
Zfish   150 KYILDNNG---IVSRQIKPATKSFIKDCVMKLHIDPAMFDQAQTEIQTMMEENTYPLFLKSDIYL 211

  Fly   940 ---------------KSCVEAEQKNQP--LPYS------GLDLDELLKTNFHLGAFSKLKKSASN 981
                           :|.|....|..|  ||..      ..|.:|           .::.:|...
Zfish   212 EYTRTGGESPKLFSDQSSVSGNGKVLPGYLPTVIEDVEWRCDQEE-----------EQIAESDPT 265

  Fly   982 AEDRRRKSLLPWHRKTRSKSRDRTEIMADMQHALMPAPPVPQN-------APLTSASLKLVCGQN 1039
            ..:|..:.||......|..:..|.:...:.:||....|..|..       ||.|||:
Zfish   266 PSNRLTQKLLLETVPQRVANSKRYQDNREYRHASWREPVNPYYVNSGYALAPATSAN-------- 322

  Fly  1040 SLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEK 1104
                 .|.:.|:|| ||.|.:                 |||.:.
Zfish   323 -----DSEQQSMSS-DADTLS-----------------LTDSSV--------------------- 343

  Fly  1105 RNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDLPD-------PKVISVKSKPK 1162
             :.|.||            ..::|.:    :|:....:|..::.||.       ||.|.|  :|:
Zfish   344 -DGVPPY------------RYRKPHR----REIHESAKVNGRVPLPHIPRTNRIPKDIHV--EPE 389

  Fly  1163 KQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSSMPP 1227
            |...|:|           .:::.::|:.:....|.:.:     :|:|:.....|..:..|.|:..
Zfish   390 KFAAELI-----------SRLEGVLREREAQEKLEERL-----KRVRLEEEGDDADISTGPSLAN 438

  Fly  1228 KQSKPMKPLPQ--GHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMR 1290
            .:..|...:..  |...|::   :|.|  ...||........:|....:..:.|...|....|..
Zfish   439 HRIPPAVHVQHYGGRYSEMS---YNGL--QLRDAHEENPESILDEHVQRVMKTPGCQSPGTGRHS 498

  Fly  1291 RQQRDGGNIPASKLPKL-------KKKSTSSSQQSEEAATTQ-----------AVADPKKPI--- 1334
            .:.|....:||.|:|.|       :.|..:......|||...           |...||:..
Zfish   499 PKSRSPDGLPAGKIPGLMMPLSGGQGKHQARQGPKGEAAHLHHHKHIHHTHYAAAGKPKEQAEAE 563

  Fly  1335 IAKLKAGVKLQVTE-----RVAEHQDELLEG---------------LKRAQLARLEDQRGTEINF 1379
            .|::..|......:     :...:.|.:..|               |.:..:.:.||.|..|:..
Zfish   564 AARMHGGFAWNTEQHHYGPKSRNYADGMSVGPNTMDPMGYSSKGSTLSKRPVRKGEDGRNFEMRE 628

  Fly  1380 DLP--DFLKNKENLSAAVSKLRKV-RASLSPVSKV----------PATPTEIPQ-----PAPRLS 1426
            .||  |..:|::.|...:...::. |...||...:          ||.|:.:.:     |.....
Zfish   629 PLPADDMERNQKILQWMMEGEKEAGRYKRSPYGSISGPKKAQGHEPARPSSVERLGAVHPWVTAQ 693

  Fly  1427 ITRSQQPVSPMKVDQEPETDLPAATQDQTEFAKAPPPLPPKPKVLPI 1473
            :..:.||..|...|                     |.:||.|...|:
Zfish   694 LRNNVQPSHPFIQD---------------------PTMPPNPAPNPL 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_RGS12-like	70..145	CDD:467194
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	34/137 (25%)
		RBD1_RGS12_like	1072..1141	CDD:340515	8/68 (12%)
		RBD2_RGS12_like	1142..1212	CDD:340587	15/76 (20%)
		GoLoco	1354..1375	CDD:214645	6/35 (17%)
axin1	XP_009297983.1	AXIN1_TNKS_BD	12..86	CDD:465215	24/102 (24%)
		RGS_Axin	93..212	CDD:188662	34/121 (28%)
		Axin_b-cat_bind	470..506	CDD:462616	5/35 (14%)
		DIX	791..867	CDD:459936