DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and rgs12a

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_699097.4 Gene:rgs12a / 570516 ZFINID:ZDB-GENE-030131-2614 Length:1371 Species:Danio rerio


Alignment Length:1571 Identity:385/1571 - (24%)
Similarity:603/1571 - (38%) Gaps:482/1571 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 IRTVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLPHETVVQLI 133
            :|.||:.||..|:||||:||.||.|..||..|||...||..||.::.||..:||:..|:.||:||
Zfish    12 VRRVEMERGRAGYGFTIAGQAPCVLRGIIKGSPAHSVGLLPGDRVLRVNDTDVSEASHDVVVKLI 76

  Fly   134 GNSFGSIRMQIAENYYSD-------SSDEENAHATLRGQLLAASLRHKPRFLH------HKAKL- 184
            |.|..|:.:.:..   .|       |||||          |....:.|..:|:      ...|| 
Zfish    77 GTSSKSLCLLVTS---GDRPPMACCSSDEE----------LGCQNKSKRPWLNPGIKDPFPGKLD 128

  Fly   185 -----------------------------HRLRNSPQKKLNPPEA----VEPHKSKSSPD----H 212
                                         |:.:...|:.|:.|:.    .:..:||.:.|    .
Zfish   129 GRDLKEPILQSVGSFDTVFEISDQGTMTPHQEKQKKQRPLSEPDVSYWLQQQQRSKGNVDILSQD 193

  Fly   213 PTLKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSK--LQT 275
            .|.:.|.|| .:.::|....|:|:        .|:.|...:||||:.::|:...:|.:.:  ||.
Zfish   194 ETSRVVSED-SVFSDLQSQNDLAS--------DSSILNVAMIVGYINSMELELVMSQTEEDALQV 249

  Fly   276 VRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRFFGLVTSA 340
            :|.||.|:..|::..::|||.:..:.:.|......|||:|.:..|......:| ::||||||:  
Zfish   250 IRQCISKIGIEQKTHSLVLMKVKCNCVQLCDDRDVVLASYPAENLALCVICTE-DSRFFGLVS-- 311

  Fly   341 VHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCL 405
                 |:.......|...:    ::...||||.||.:|.||.:|......|.:.||.||.:..||
Zfish   312 -----IDSTKNIDTGRQTS----TLKTLCHVFFIDPELYEHKEHQSIIGHFGIPCTPDPDTQSCL 367

  Fly   406 EFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEISTTTS 470
            |||.....:.:.:..:|          :...||     .......:.:.:..:.|.::..|.:.|
Zfish   368 EFPQTPHSISHFISVLY----------ADMGDY-----IEKLRLKLDSENPDEGSQNARNSGSGS 417

  Fly   471 NSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHA--GPPTYPAPARPLGIVGIPDNRLTVRA 533
            .||||||  |......|.::       |..:..:.:.  .||.|           ...:|.:...
Zfish   418 GSDSGIG--NASPEERDSLI-------GQWSFTSPNICNPPPPY-----------YSQHRNSTFL 462

  Fly   534 MPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDD 598
            .|:...||..|...|:              .|||                               
Zfish   463 KPECRCLLSEPLTGSA--------------QPAT------------------------------- 482

  Fly   599 ISLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQS 663
               .|..|:..:|..|..   ||...:.:|       |.|..|   ||  .|.|:|.:|      
Zfish   483 ---PSGVPAGADGSAFTP---VPLSKQSNL-------PPKQRA---GQ--RRPSIGLKA------ 523

  Fly   664 SVSGACMDQTMDTWASLQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRRAW 728
                                      |...|..:|..||:|..|.:|......||.         
Zfish   524 --------------------------RWQKSRPNSIECLVEGDNDDPKSKCSTLPP--------- 553

  Fly   729 GQSSFRTPRSDKVAKEQQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQ------- 786
                         |.||....:..|:..|..:|      :...|.|.|...||.::.:       
Zfish   554 -------------AMEQIPTLRYKPLEHTQRIN------FTPQLELTSRFFSSAAKQKDGENKGS 599

  Fly   787 --LSLLQVPKVLTTPAPP--------------SAITASVAAEGAAQDHGCPS------------- 822
              .:|.:....:..|:.|              ||.:....:.|..|.|.|.|             
Zfish   600 LFWALTRGRSSVRRPSGPAKRLSLAHSLNDLESAASDGERSGGGVQRHDCSSVSSLDSNGSLPSV 664

  Fly   823 ------------SWAGSFERMLQDAAGMQTFSEFLKKEFSAENIYFWTACERY-RLLESEADRVA 874
                        .||.||||:|||..|::.||||||||||.|||.||.|||.: ::.|.:..:::
Zfish   665 TNHCRFTERRVALWAVSFERLLQDPVGVRYFSEFLKKEFSEENILFWQACECFSQVPEHDKKQLS 729

  Fly   875 Q-AREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDL 938
            | |:||:.:.|::.::.|||:||||: |.::.|....|::|...|.|||:|||.|||.||::|.|
Zfish   730 QKAKEIYNRFLSSKATMPVNIDSQAQ-LADDVLTAPQPNMFKQPQLQIFNLMKMDSYARFLKSTL 793

  Fly   939 YKSCVEAEQKNQPLPYSGLDLDEL--------LKTNF--HLGAFSKLK------KSASNAEDRRR 987
            |:.|:.||.:.:|||      |..        .|.:|  ....||..|      |:..:::|.|.
Zfish   794 YQECMLAEVEGRPLP------DPCPIPCSPAPSKHSFTSDRSTFSTPKKENRKPKTGRSSDDLRE 852

  Fly   988 K------SLLPWHR-KTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNSLSDLH 1045
            |      ....|:| .:..|.:.:.|           ||.:|.:.             |...:..
Zfish   853 KHSDKKNGFFSWYRYPSIGKGQKKRE-----------APDLPYHC-------------NGRRESQ 893

  Fly  1046 SSRSSLSSFDAGTATGG--------QGAS------TESVYSLCRVILTDGATTIVQTRPGETVGE 1096
            .|.||.:|.:..|:..|        :|:|      .|.....|.|.|.||::..:..|.|.::.:
Zfish   894 GSLSSGASQELNTSCSGGKNEQCELRGSSCALDKERERCSRTCTVTLPDGSSCSIPLRQGASIRQ 958

  Fly  1097 LVERLLEKRNLVYPYYDIVFQGSTKSIDVQQPSQILAGKEVVIERRVAFKLDL-PDPKVISVKSK 1160
            ::..|.:|:::.....|:...|..|.:.:.|.|..|:.:|:.:|:|..|:||| |..:.:.:|:|
Zfish   959 VLLELCQKQHINLAAVDLFLTGGEKPLVLDQDSITLSSRELRLEKRTLFRLDLVPINRSVGLKAK 1023

  Fly  1161 PKKQLHEVIRPILSKYNYKM-EQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSS 1224
            |.|.:.||:||:::||..:: :.|..|..:|:| :||..|::..||  ||:|:            
Zfish  1024 PTKPVTEVLRPVVAKYGLQLGDLVARISGETEV-LDLGVPISNLDG--LRVVL------------ 1073

  Fly  1225 MPPKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERM 1289
                                          .:||.|.:|||:.::                    
Zfish  1074 ------------------------------ERADPAKAEKSKTLN-------------------- 1088

  Fly  1290 RRQQRDGGNIPASKLPKLKKKSTSSSQQSEEAATTQAVADPKKPIIA--KLKAGVKLQVTERVAE 1352
                        ||.|..||........:......:|..:.|.|..|  :.|.|.|..:.|    
Zfish  1089 ------------SKTPAAKKGFPRERDDNSTVKPLKADVEDKHPRTAASERKKGKKNHIDE---- 1137

  Fly  1353 HQDELLEGLKRAQLARLEDQRGTEINFD--LPDFLKNKENLSAAVSKLRKVRASLSPVSKVP--- 1412
             .:|..|.|.|||.:|::||||.....|  |||||:...:     .|.:...:..:|.|..|   
Zfish  1138 -TEEFFELLSRAQSSRVDDQRGLLRKEDLVLPDFLRVNPD-----PKPQSPPSCSTPTSHKPGHT 1196

  Fly  1413 ATPTEIPQPAPRLSITRSQQ-------PVSPM-----KVDQEPETDLPAAT--------QDQTEF 1457
            .|.:..|.| |:.|.....|       |:||:     ..:||.|..|...|        ...:..
Zfish  1197 TTTSTNPHP-PKPSPCNGHQASAPFSAPLSPILRSAGAREQEEEEGLGDLTLVAEGDISSPNSTL 1260

  Fly  1458 AKAPPPLPPKP 1468
            ...|||:.|.|
Zfish  1261 LPPPPPVSPPP 1271

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 36/75 (48%)
PTB_RGS12 251..391 CDD:269984 41/141 (29%)
RGS_R12-like 828..941 CDD:188661 57/114 (50%)
RGS12_RBD 1073..1145 CDD:176412 18/71 (25%)
RBD 1144..1213 CDD:128731 27/70 (39%)
rgs12aXP_699097.4 PDZ_signaling 12..87 CDD:238492 36/74 (49%)
PTB_RGS12 223..353 CDD:269984 41/141 (29%)
RGS_R12-like 682..796 CDD:188661 57/114 (50%)
RGS12_us1 802..891 CDD:293219 21/118 (18%)
UBQ 936..1007 CDD:294102 18/70 (26%)
UBQ 1007..1075 CDD:294102 27/112 (24%)
GoLoco 1139..1160 CDD:280368 11/20 (55%)
RGS12_usC 1175..1284 CDD:293218 23/103 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 113 1.000 Domainoid score I6078
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 396 1.000 Inparanoid score I1913
OMA 1 1.010 - - QHG49673
OrthoDB 1 1.010 - - D144440at33208
OrthoFinder 1 1.000 - - FOG0006108
OrthoInspector 1 1.000 - - otm24643
orthoMCL 1 0.900 - - OOG6_106352
Panther 1 1.100 - - O PTHR45945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5044
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.980

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