DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and PARD3

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	1152	Identity:	192/1152 - (16%)
Similarity:	362/1152 - (31%)	Gaps:	356/1152 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HHPPLPITGASGSTAVGTGAAAAEDASPAANSGPAPIS------TSTTPSGSNSQQHQRRRKKRA 62
            :|||..|...|         .....|.|:.....||.|      ::|..||.|:    ::..||.
Human   409 NHPPEQIDSHS---------RLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT----KKIGKRL 460

  Fly    63 NYNYNGIRTVEVRRGYNGFGF-------TISGQQPCRLSCIISSSPAEQAG-LRSGDFLISVNGL 119
            |        :::::|..|.||       ||.|..|..:..|:....|.|.| |::||.||.|||:
Human   461 N--------IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517

  Fly   120 NVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKL 184
            ::.....|.||.|:.::                        .:.|.:.....|.:..|  |..:|
Human   518 DLVGKSQEEVVSLLRST------------------------KMEGTVSLLVFRQEDAF--HPREL 556

  Fly   185 HRLRNSPQKKLNPPEAVEPHKSKSSPDHPTLKP------VLEDPPLTANLSKAADV--------- 234
            :         ..|.:...|.::|:..:...|.|      :..:.||..:.|....|
Human   557 N---------AEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKE 612

  Fly   235 --ANVSAMVRAV---GSAALECRVIVGYLGTIEMPKQISHSSKL-QTVRSCIRKLRQEKRQPTIV 293
              |::...|:::   |:|:.:.|:.|.     :....::..|.| :|.:..:..||:
Human   613 NHADLGIFVKSIINGGAASKDGRLRVN-----DQLIAVNGESLLGKTNQDAMETLRR-------- 664

  Fly   294 LMCITPDSLSLQSSSGGVLATYSSARLN-----------------FVSSSSESENRFFGLVTSAV 341
                   |:|.:.:..|::....:.|::                 ..::..:.|.|....:.|.:
Human   665 -------SMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGI 722

  Fly   342 HNTQIEEEYEPSAGSAAA-----AGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPIS 401
            ..  ::|  .||..:|.:     :|...:|.:.::...||.:||..:
Human   723 EG--LDE--SPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDR------------------ 765

  Fly   402 NLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAAAHSPQPSNHSEIS 466
                                  :.:|||    |.:|..:.                  |:|.::.
Human   766 ----------------------LPVLPP----HLSDQSSS------------------SSHDDVG 786

  Fly   467 TTTSN----SDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIV----- 522
            ..|::    :.:.|..:.||:...|...|:.|...|.|..:.:......: :.|..|..|
Human   787 FVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQF-SDASQLDFVKTRKS 850

  Fly   523 -----GIPDNRLTVRAMPDHSALLRSPP----ASSSLRRPNLLASFNL------------IQSPA 566
                 ||.| ...:..:.|..|  .||.    .|..|::.:.|.|...            ...|.
Human   851 KSMDLGIAD-ETKLNTVDDQKA--GSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPR 912

  Fly   567 TNLTSTRSCDDVLNLFVD---DSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSL 628
            ..:...|.|::.....:|   |.|     ....||..:.:.....:|.         .|..|.|:
Human   913 PRIIRGRGCNESFRAAIDKSYDKP-----AVDDDDEGMETLEEDTEES---------SRSGRESV 963

  Fly   629 ALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHKSHKDRTSM 693
            :..:....|.|..|:.|                 :...|...|:..|.....:...:. |::..|
Human   964 STASDQPSHSLERQMNG-----------------NQEKGDKTDRKKDKTGKEKKKDRD-KEKDKM 1010

  Fly   694 SASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQQLGQSSPVRRTA 758
            .|...   :|:........|............:...|.|| |...:::..:|:|....:..|...
Human  1011 KAKKG---MLKGLGDMFRFGKHRKDDKIEKTGKIKIQESF-TSEEERIRMKQEQERIQAKTREFR 1071

  Fly   759 SMNASDNDM-----YIKTLMLDSDL------------------KSSRSQHQLSLLQVPKVLTTPA 800
            ...|.:.|.     :.:|...|.:|                  :|.|..|.:..|.........:
Human  1072 ERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNS 1136

  Fly   801 PPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFLKKEFSAE------------- 852
            .||.:.::   .....:|.........|::..||..     .|..::.:|.|
Human  1137 KPSPVDSN---RSTPSNHDRIQRLRQEFQQAKQDED-----VEDRRRTYSFEQPWPNARPATQSG 1193

  Fly   853 --NIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIFA 915
              ::......:|.|..|.|:.:.||.:.......:..::..|:.||..::             ::
Human  1194 RHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQN-------------YS 1245

  Fly   916 PAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKSAS 980
            |.:       .|.|.:...|...|:.     .:|..|...|.:...:|:|           :...
Human  1246 PGE-------GFQSAKENPRYSSYQG-----SRNGYLGGHGFNARVMLET-----------QELL 1287

  Fly   981 NAEDRRRKSLLPWHRKTRSKSR-DRTEIMADMQHALMPAPPVPQNAP 1026
            ..|.||::..:.....:...|. |..:.:.|..:| .|..|..|:.|
Human  1288 RQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYA-PPKGPFRQDVP 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	24/83 (29%)
		PTB_RGS12	251..391	CDD:269984	24/162 (15%)
		RGS_R12-like	828..941	CDD:188661	20/127 (16%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262
		PDZ_signaling	272..347	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		11/47 (23%)
		PDZ_signaling	465..544	CDD:238492	25/102 (25%)
		PDZ_signaling	588..681	CDD:238492	18/112 (16%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		47/293 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		19/127 (15%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		74/480 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356		39/250 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810