DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and grid2ipb

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1307	Identity:	257/1307 - (19%)
Similarity:	414/1307 - (31%)	Gaps:	455/1307 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HHHHPPLPITGASGSTAV--GTGAAAAEDASPAANSGPAPISTSTTP----SGSNSQQHQRRRKK 60
            ||..|    .|:..:::|  .||      ..||.|......|.:..|    ||.|.
Zfish   289 HHERP----QGSKRASSVPRDTG------DEPAQNDRTLRKSNTMIPTQYVSGVNQ--------- 334

  Fly    61 RANYNYNGIRTVEVRRGYNGFGFTISGQQPCRLSCIISSSPAEQAGLRSGDFLISVNGLNVSKLP 125
                     ||:.|.||...||||:.|..|..:..::..||||..||::||.::.:|||::....
Zfish   335 ---------RTIRVYRGKKSFGFTLRGHAPVWIDSVMPGSPAEACGLKTGDRILFLNGLDMRNCS 390

  Fly   126 HETVVQLIGNSFGSIRMQIAE----NY-YSDSSDEENAHATLRGQLLAASLRHKPRFLHHKAKLH 185
            ||.||.::..| |::...:.|    :| .|||..||...|........:||:.....|....::|
Zfish   391 HEKVVSMLQGS-GAMPSLVVEEGPVDYPQSDSEPEETPSAPRSRSPALSSLQWVAEILPPSIRVH 454

  Fly   186 RLRNSP--------QKKLNPPEAVEPHKSKSSPDHPTL----KPVLEDPP-----------LT-- 225
            ....|.        |::....:|:|......:.|  ||    .|||:.|.           ||
Zfish   455 GRTFSQQLEHLLTLQERYTICKALETFFQHRNVD--TLIVDVFPVLDTPAKQLIWQFIYQLLTYE 517

  Fly   226 -----------------ANLSKAADVANVSAMVRAVGS---------AALECRVIVGY---LGTI 261
                             |.....|:....|:.:|..|:         ::.:|  |:|.   :||.
Zfish   518 EQEHCKTKIARFLGFKSAEPEVGAETHRRSSSMRVSGTSHKNTVRERSSDDC--IIGTHLGMGTF 580

  Fly   262 EMP-----------------KQISHSSKLQTVRSCIRKLRQEKRQPTIVLMCITPDSLSLQSSSG 309
            ..|                 ..:||.:.:.|....:..::               .|.||||.|.
Zfish   581 TDPVTPEERQCGDGTSFPESPDLSHMTGVYTELGNVYPVK---------------SSQSLQSHSS 630

  Fly   310 GVLATYSSARLNFVSSS---SESENRFFGLV---TSAVHNTQIE--EEYEPSAGSAAAAGHISIS 366
            ...|....|..|..:.|   |.:.||..||.   |.:....|.|  ::...|..|..:..::|:.
Zfish   631 PRAAGMGLAESNTYTQSFTHSTAGNRKSGLSLTWTDSFPGPQFETYQQTVASPDSVDSNPYVSLD 695

  Fly   367 HSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRDPISNLCLEFPNNSEYVVNLVRSMYTMRILPPAS 431
                                          ..|.|.|    |::....:...|.::|.. .||.|
Zfish   696 ------------------------------SPPASPL----PSDELSPLPQRRKLFTFS-RPPRS 725

  Fly   432 R---------SHQADYEAGAGAAAAGG----AVAAAHSPQPSN---HSEISTTTSNSDSGIGFNN 480
            |         |.|..:.........||    ...:....|..|   | |:|:.:|...|.   ::
Zfish   726 RDTDKFLDALSEQLGHRVNIVDDFKGGENDYEEMSFQDEQEVNMLPH-ELSSASSEDHSS---SD 786

  Fly   481 DCTNISDRILVVDFLAAGAGAAAAAHAGPP--TYPAPARPLGIVGIPDNRLTVRAMPDHSALLRS 543
            |.|::|             .::.:.|..||  :.|.|..||.....|.   .:...|:|  |.:.
Zfish   787 DSTSVS-------------YSSGSDHIPPPPQSPPPPPPPLQFTDSPS---PLPITPEH--LPQP 833

  Fly   544 PPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSL 608
            |||..  ..|       :|..|                  ...||...|    :..|||...|:.
Zfish   834 PPAFQ--HHP-------IIAPP------------------PPPPRPFLA----NRPSLHKVLPTR 867

  Fly   609 DEGHT-FAHPACVPRKMRRS---------LALETPTTPHKLSAQVFGQPGSRHSLGFEAIDSVQS 663
            :|... .:||       |||         |.|..|.....|.:.....|...|:       |.|.
Zfish   868 EELRAQHSHP-------RRSSPQPSSQPILQLHQPKAHPILQSSPHTSPQPPHT-------SAQH 918

  Fly   664 SVSGACMDQTMDTWASLQNLHKS--HKDRTSMSASSSSHCLLEATNSEPDLGNRALPANASPFRR 726
            :              .||:..:|  ...:|::..:|.|....::.:|:|
Zfish   919 T--------------RLQHPSQSIYQSQQTTVPRTSPSLTKQKSLHSQP---------------- 953

  Fly   727 AWGQSSFRTPRSDKVAK----------EQQQLGQSSPVRRTASMNASDND-MYIKTLMLDSDLKS 780
              .|.||....|.||..          :...|.:.||       .||||: |.:|.|..:
Zfish   954 --SQQSFEGTLSSKVPPPPPPPLPPPCDPPPLPKPSP-------KASDNNHMSVKRLRWE----- 1004

  Fly   781 SRSQHQLSLLQVPKVLTTPAPPSAITASVAAEGAAQDHGCPSSWAGSFERMLQDAAGMQTFSEFL 845
                      ||..                :||        :.|.     .|.|.......|:.:
Zfish  1005 ----------QVEN----------------SEG--------TIWG-----QLGDDPDYHKLSDMV 1030

  Fly   846 KKEFSAENIYFWTACERYRLLE----SEADRVAQAREIFAKHLANNSS--------DPVNVDSQA 898
            |  :...::||.|......|.|    .|..:.....||.:...|.|:|        .|..:....
Zfish  1031 K--YLDLDLYFGTQRNSISLPEPTFLPENLKKKDVVEILSHKKAYNASILIAHLKLAPKELRDIL 1093

  Fly   899 RSLTEEKLADAAPD---IFAPAQKQIFSLMKFD--------------------SYQRFIRSDLYK 940
            .:::.|:|..|...   ::||..:::.....:|                    .|:..:||.|:|
Zfish  1094 MTMSTERLEPAHIKQLLLYAPDDEEVKQFQHYDQDPAKLSEPDQFVLQMLLVPEYKTRLRSLLFK 1158

  Fly   941 SCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKK----------SASNAEDRRRKSLLPWHR 995
            :.|:.:.:.....|     :.:.|.:..|....:|.|          ..:|.:.:..|:
Zfish  1159 TTVQEKTEEMRAAY-----ECIYKASLELKNSKRLAKILEFVLAMGNYLNNGQPKTNKT------ 1212

  Fly   996 KTRSKSRDRTEI--------MADMQHALMPAPPVPQNAP--------LTSASLKLVCGQNS---- 1040
             |..|....||:        .:...|.|  |..:.|:.|        |.:..|.....|.:
Zfish  1213 -TGFKINFLTELNTTKTVDGKSTFLHIL--AKSLCQHFPELLGFSRDLITVPLAAKVNQRTITAD 1274

  Fly  1041 LSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKR 1105
            |||:||:..     |..||.....|:.|..::.......:.....||     ::..|.:|.:::.
Zfish  1275 LSDVHSTIQ-----DIRTACVKIPATAEDRFAAVMSSFLENCHPAVQ-----SLDSLQQRAMDEF 1329

  Fly  1106 NLVYPYY 1112
            :.|..|:
Zfish  1330 HKVASYF 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492	28/75 (37%)
		PTB_RGS12	251..391	CDD:269984	30/167 (18%)
		RGS_R12-like	828..941	CDD:188661	26/147 (18%)
		RGS12_RBD	1073..1145	CDD:176412	6/40 (15%)
		RBD	1144..1213	CDD:128731
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492
		HN_L-delphilin-R1_like	183..262	CDD:259820
		PDZ_signaling	335..410	CDD:238492	28/75 (37%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	14/80 (18%)
		FH2	995..1360	CDD:280362	71/412 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900