DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment loco and grip1

DIOPT Version :9

Sequence 1:NP_732773.1 Gene:loco / 42672 FlyBaseID:FBgn0020278 Length:1541 Species:Drosophila melanogaster
Sequence 2:XP_009298419.1 Gene:grip1 / 558006 ZFINID:ZDB-GENE-041210-125 Length:1191 Species:Danio rerio


Alignment Length:1457 Identity:266/1457 - (18%)
Similarity:468/1457 - (32%) Gaps:471/1457 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 RKKRANYNYNGIRTVE-VRRGYNGFGFTISG-----QQPCRLSCIISSSPAEQAG-LRSGDFLIS 115
            |::.....:.|..||| :::.....|.|:||     .:| |:|.:.....|.::. |..||::.|
Zfish    66 RRQSIPDEFKGTSTVELIKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLNVGDYIKS 129

  Fly   116 VNGLNVSKLPHETVVQLIGNSFGSIRMQIAENYYSDSSDE-------------ENAHATL--RGQ 165
            |||:|::|..|:.::.|:.|        :.|....:...|             :|...||  .|.
Zfish   130 VNGINLTKFRHDEIISLLKN--------VGERVVLEVEYELPPVSVQGSGVMFKNVEVTLHKEGN 186

  Fly   166 LLAASLR---HKPRFLHHKAKLHRLRN----------SPQKKLNPPEAVEPHKSKSSPDHPTLKP 217
            .....:|   |:.|.......:..:|.          .|..:|...:.:..|    ...|.....
Zfish   187 TFGFVIRGGAHEDRNKSRPVTITTIRPGGPADREGTIKPGDRLLSIDGIRLH----GASHAEAMS 247

  Fly   218 VLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSCIRK 282
            :|:.....|.|....||:.:.::..|.|...:|....:|          .|....|.|...|.::
Zfish   248 ILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKSMG----------SSLGLALSTSMYCNKQ 302

  Fly   283 LRQEKRQPTIVLMCITPDSLSLQSS---SGGVLATYSSARLNFVSSSSESENRFFGLVTSAVHNT 344
            :        |::..:.|.|::.:..   :|..:.:.....:.:.:.:..::     |:.||..:.
Zfish   303 V--------IIIDKVKPASIADRCGALHAGDHILSVDGTSMEYCTLAEATQ-----LLASASEHV 354

  Fly   345 QIE-EEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHA-----QHLQRAH--EFRLQCTRDPIS 401
            ::| ..:..:..:.....|:.:..|......::....::     ||....|  :...|..:...|
Zfish   355 KMEILPHHQTRLALKGPEHVKVQRSTRPLPWESGTNNNSNFLPYQHYNTYHPDQSHSQAKKTSPS 419

  Fly   402 N--LCLEFPNNSEYVVNLVRSMYTMRILP----PAS--------RSHQADYEAGAGAAA-----A 447
            |  |...|...|....:|  |...|..||    |.|        :..:.||::....|:     |
Zfish   420 NPPLGSSFSPTSMSAYSL--SSLNMNTLPRTMYPTSPRGTMMRRKLKKKDYKSSMSLASSTVGLA 482

  Fly   448 GGAVAAAHSPQPSNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTY 512
            |..|          |:|.:..|..|||.:||.              ....|...|....:.||..
Zfish   483 GQVV----------HTETTEVTLISDSIMGFG--------------IQLQGGVFATETLSSPPLI 523

  Fly   513 -----PAPARPLGIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTST 572
                 .:||...||:.|.|..|::..:|..         .|:|...|.|...:.|.|..|     
Zfish   524 AYIDPDSPAERCGILQIGDRILSINGIPTE---------DSTLEETNQLLRDSSITSKVT----- 574

  Fly   573 RSCDDVLNLFVDDSPRTLAAVASMDDISLHSAAPSLDEGHTFAHPACVPRKMRRSLA---LETPT 634
                  |.:..|.:...:.:..:. .:.| ...|.::.|.|.:.|:  .||...:|.   ::..:
Zfish   575 ------LEIEFDVAESVIPSSGTF-HVKL-PKKPGVELGITISSPS--SRKPGDALIISDIKKGS 629

  Fly   635 TPHKLSAQVFGQPGSRHSLGFEAIDSVQSSVSGACMDQTMDTWASLQNLHK----SHKDRTSM-- 693
            ..|:......|..       ..|||:::  :....|:..:......::|.|    ..:|.:.:  
Zfish   630 VAHRTGTLELGDK-------LLAIDNIR--LDNCSMEDAVQILQQCEDLVKLKIRKDEDNSGVLR 685

  Fly   694 --SASSSSHCLLEATNSEPDLGNRALPANASPFRRAWGQSSFRTPRSDKVAKEQQ--------QL 748
              |...::..||.....|.:.....:  .....:|..|      |....::..::        .|
Zfish   686 AGSVDRNARVLLACVADEQETSGAII--YTVELKRYGG------PLGITISGTEEPFDPIIISSL 742

  Fly   749 GQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSRSQHQLSLLQVP------KV-----LTTPAPP 802
            .:.....||.:::..|..:.|.:    :.||.......:.|||:.      |:     |.:|.||
Zfish   743 TKGGLAERTGAIHIGDRILAINS----NSLKGKPLSEAIHLLQMAGESVTLKIKKQGELPSPKPP 803

  Fly   803 SAITASVAAEGAAQDHG-------------CPS------SWAGSFERMLQDAAGMQTFSEFLKKE 848
            | :|..:......:|.|             .||      ||.||    ..||    |||......
Zfish   804 S-VTGRLNNLSDLEDDGQKAGKLSDIYSTTIPSVDSAVESWDGS----AIDA----TFSTQAPTG 859

  Fly   849 FSAENIYFWTACERYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDI 913
            |.|....|          .|...|.|:.        :..|..|||                    
Zfish   860 FQASGYSF----------HSHEWRNAKP--------SRGSLSPVN-------------------- 886

  Fly   914 FAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGAFSKLKKS 978
                                          .:.|:|..||..|:.:|:.            .:.|
Zfish   887 ------------------------------SSRQRNNILPDFGIGVDDW------------DRPS 909

  Fly   979 ASNAEDRRRKSLLPWHRKTRSK---SRDRTEIMADMQHALMPAPPVPQNAPLTSASLKLVCGQNS 1040
            ||.|      |.||....:.|:   ..|.||            |...:|           ....:
Zfish   910 ASGA------STLPTGLISDSRFTVGHDGTE------------PDQEEN-----------FWSQA 945

  Fly  1041 LSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGELVERLLEKR 1105
            |.||.              |.||                .|....::.:|        :|||.||
Zfish   946 LEDLE--------------TCGQ----------------SGILRELEDKP--------DRLLNKR 972

  Fly  1106 NLVYPYYDIVFQGSTKSIDVQ-QPSQILAGKEVVIERRVAFKLDLPD-------PKVISVKSKPK 1162
            ||.  ....:..||:.|::.. .|::...|::...:.|.:.|.....       |..:..|:...
Zfish   973 NLA--ILATIMSGSSLSLNHDPAPTRSHLGRQASFQERGSNKPQYSQANRSNTLPTDVGRKAFAM 1035

  Fly  1163 KQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQ-PVTMADGQRLRIVMVNSDFQVGGGSSMP 1226
            :::.:.|:.|:|....::.:|. :::|:    ||.. ..:::||...:.|.|| :.:.||     
Zfish  1036 RRMKQEIKDIMSPTPVELHKVS-LLKDS----DLEDFGFSVSDGVLEKGVYVN-NIRPGG----- 1089

  Fly  1227 PKQSKPMKPLPQGHLDELTNKVFNELLASKADAAASEKSRPVDLCSMKSNEAPSETSSLFERMRR 1291
            |.:...:||             ::.||...     ..::|..|.|.:....|.|           
Zfish  1090 PAEIGGLKP-------------YDRLLQIN-----HVRTRDFDCCLVVPLIAES----------- 1125

  Fly  1292 QQRDGGNIPASKLPKLKKKSTSSSQQSE-------EAATTQAVADPKKPIIAKLKAGVKLQVTER 1349
                 ||    ||..:..::..|||.||       |........||.:..:|.|:.|        
Zfish  1126 -----GN----KLDLVISRNPVSSQPSELNPLSNDETVNWTDTGDPLEQPVAGLEQG-------- 1173

  Fly  1350 VAEHQDELLEGLKRAQLARLEDQRGTE 1376
              :|         .:.||.|||:..|:
Zfish  1174 --QH---------NSTLAGLEDRDPTK 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
locoNP_732773.1 PDZ_signaling 69..145 CDD:238492 23/82 (28%)
PTB_RGS12 251..391 CDD:269984 18/150 (12%)
RGS_R12-like 828..941 CDD:188661 15/112 (13%)
RGS12_RBD 1073..1145 CDD:176412 15/72 (21%)
RBD 1144..1213 CDD:128731 13/76 (17%)
grip1XP_009298419.1 PDZ_signaling 79..159 CDD:238492 24/88 (27%)
PDZ_signaling 178..261 CDD:238492 14/86 (16%)
PDZ_signaling 276..359 CDD:238492 14/105 (13%)
PDZ_signaling 490..578 CDD:238492 26/121 (21%)
PDZ_signaling 591..675 CDD:238492 16/96 (17%)
PDZ_signaling 711..792 CDD:238492 14/92 (15%)
PDZ_signaling 1053..1133 CDD:238492 25/128 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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