Protein Alignment loco and lnx2a

DIOPT Version :9

• Sequence 1: NP_732773.1
• Gene: loco / 42672
• FlyBaseID: FBgn0020278
• Length: 1541
• Species: Drosophila melanogaster
• Sequence 2: NP_001106696.2
• Gene: lnx2a / 553331
• ZFINID: ZDB-GENE-060228-2
• Length: 737
• Species: Danio rerio
• Alignment Length: 684
• Identity: 138/684 - (20%)
• Similarity: 224/684 - (32%)
• Gaps: 189/684 - (27%)

  Fly   167 LAASLRHK-PRFLHHKAKLHR--LRNSPQK--KLNPPEAVEPHKSKSSPDHP------------T 214
            |.|.|:|: |.....:.||.|  :..|..:  ..|||::.:....:.:|..|            |
Zfish   128 LEAHLKHRCPGTQSQRTKLERTQMEGSEDRVTATNPPKSPQTEIKEDTPSPPAGSNACNNVPTWT 192

  Fly   215 LKPVLEDPPLTANLSKAADVANVSAMVRAVGSAALECRVIVGYLGTIEMPKQISHSSKLQTVRSC 279
            .:|.:::|.    ..::.:..:|.         .|||.     |..::.|..          ..|
Zfish   193 EEPGIDNPA----FEESTEEDSVH---------GLECA-----LPRVKRPLS----------NPC 229

  Fly   280 IRKLRQEKRQ-------PTIVLM----CITPDSLSLQSSSGGVLATYSSARLNFVSSSSESENRF 333
            |..||.....       .|:.|.    |:     .|.|...|.:.|....|.|   ..||.....
Zfish   230 IHLLRTGSSASSGWDFVETLPLSAEEGCV-----KLPSLPEGEITTIEVHRTN---PYSEMGISI 286

  Fly   334 FGLVTSAVHNTQIEEEYEPSAGSAAAAGHISISHSCHVFVIDTKLIEHAQHLQRAHEFRLQCTRD 398
            .|...:.:.|..|:|.|...                 |...|.:|:        |.:..||....
Zfish   287 VGGNETPLINVVIQEVYRDG-----------------VIARDGRLL--------AGDQILQVNNV 326

  Fly   399 PISNLCLEFPNNSEYVVNLVRSMYTMRILPPASRSHQADYEAGAGAAAAGGAVAA----AHSPQP 459
            .|||:...|..::     |.|...|:::  ...|..:......|..|:..|:.|:    .|..:.
Zfish   327 DISNVPHNFARST-----LARPCATLQL--TVLRERRCSARPPAATASPKGSPASIRITLHKRES 384

  Fly   460 SNHSEISTTTSNSDSGIGFNNDCTNISDRILVVDFLAAGAGAAAAAHAGPPTYPAPARPLGIVGI 524
            |....|.......::|             :.::|.|..|..|
Zfish   385 SEQLGIKLVRRTDEAG-------------VFILDLLEGGLAA----------------------- 413

  Fly   525 PDNRL----TVRAMPDHSALLRSPPASSSL-----RRPNLLASFNLIQSPATNLTSTRSCDDVLN 580
            .|.||    .|.|:.:|.....:|..::.:     .|.|||.|.:..|:.|.:..||.:.|
Zfish   414 KDGRLCSNDRVLAVNEHDLRHGTPELAAQIIQASGERVNLLISRSSKQTMAVHTGSTLTRD---- 474

  Fly   581 LFVDDSPRTLAAVASMDDI-SLHSAAPSLDEGHTFAHPACVPRKMRRSLALETPTTPHK-LSAQV 643
            ::..|....|.:.|:...: |||.|..|.....:    .||..|.:.   :.....||: |...|
Zfish   475 IWSHDHIPPLPSTATPSPVPSLHLARSSTQRDLS----QCVNCKEKH---ITVKKEPHESLGMTV 532

  Fly   644 FGQPGSRHSLGFEAIDSVQSSVSGACMD-----QTMDTWASL--QNL-HKSHKDRTSMSASSSSH 700
            .|..||:.......:.|||..   .|:.     :..|...|:  |:| :.||.:......||::.
Zfish   533 AGGRGSKSGELPIFVTSVQPH---GCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLKSSATS 594

  Fly   701 C-----LLEATN-SEPDLGNRALPANASPFRRAW--------GQSSFRTPRSDKVAKEQQQLGQS 751
            |     .||.|. .||.|....||.:.:.:..:|        |..|:.....:.|.:........
Zfish   595 CSVQLKALEVTMVEEPGLDEELLPPHENDYDASWSPSWVLWLGLPSYLHSSHEIVLRRSHPGSWG 659

  Fly   752 SPVRRTASMNASDNDMYIKTLML------DSDLK 779
            ..:......|.|:...:|||::|      |..||
Zfish   660 FSIVGGYEENHSNQAFFIKTIVLGTPAYYDGRLK 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984	27/150 (18%)
		RGS_R12-like	828..941	CDD:188661
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	23/120 (19%)
		PDZ_signaling	375..455	CDD:238492	18/115 (16%)
		PDZ_signaling	515..600	CDD:238492	20/90 (22%)
		PDZ_signaling	646..730	CDD:238492	10/48 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900