DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment loco and Rgs7

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_062216.1	Gene:	Rgs7 / 54296	RGDID:	3570	Length:	477	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	114/505 - (22%)
Similarity:	184/505 - (36%)	Gaps:	130/505 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 GIVGIPDNRLTVRAMPDHSALLRSPPASSSLRRPNLLASFNLIQSPATNLTSTRSCDDVL----- 579
            |:.....|.|..|.|.|..|.::.......:|         .::|..:.:.|..|..|::
  Rat    13 GVAEESPNMLVYRKMEDVIARMQDEKNGIPIR---------TVKSFLSKIPSVFSGSDIVQWLIK 68

  Fly   580 NLFVDDSPRTL------AAVASMDDISLHSAAPSLDEG--HTFAHPACVP--------------- 621
            ||.::|....|      ||......||.| .....|:|  :.|..|...|
  Rat    69 NLTIEDPVEALHLGTLMAAHGYFFPISDH-VLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYL 132

  Fly   622 --RKMRRSLALETPTTPHKLSAQ-----------VFGQPGS-------RHSLGFEAIDS------ 660
              |.|:....||......:..|:           :|.|..:       |..:..:.:||
  Rat   133 CKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFW 197

  Fly   661 -VQSSVSGACMDQT-MDTWAS--LQNLHKSHKDRTSMSASSSSHCLLEATNSEPDLGNRALPANA 721
             |...|.| |::.| :|...|  ::|.||:.|....:.....||........|.
  Rat   198 DVHRPVPG-CVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPET----------- 250

  Fly   722 SPFRRAWGQSSFRTPRSDKVAKE----QQQLGQSSPVRRTASMNASDNDMYIKTLMLDSDLKSSR 782
                        :.|..|::.::    |.||               |......:.:.||.|..:.
  Rat   251 ------------KPPTEDELHRQIKYWQIQL---------------DRHRLKMSKVADSLLSYTE 288

  Fly   783 SQHQLSLLQVPKVLTTPAPP--SAITASVAAEGAAQDHGCPSS-----WAGSFERMLQDAAGMQT 840
            ...:.....||   ..|:.|  |..|.....|.:.:    ||.     |....:..|:|..|.:.
  Rat   289 QYVEYDPFLVP---PDPSNPWLSDDTTFWELEASKE----PSQQRVKRWGFGMDEALKDPVGREQ 346

  Fly   841 FSEFLKKEFSAENIYFWTACE--RYRLLESEADRVAQAREIFAKHLANNSSDPVNVDSQARSLTE 903
            |.:||:.|||:||:.||.|.|  :.|.:.....||   :||:.:.||..:...:|:||::...|.
  Rat   347 FLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRV---QEIWQEFLAPGAPSAINLDSKSYDKTT 408

  Fly   904 EKLADAAPDIFAPAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLP 953
            :.:.:.....|..||:.|:.|||.|||.|||||..|:..::|::|.:.:|
  Rat   409 QNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKRKGRNIP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	42/114 (37%)
		RGS12_RBD	1073..1145	CDD:176412
		RBD	1144..1213	CDD:128731
Rgs7	NP_062216.1	DEP_RGS7-like	29..116	CDD:239897	20/96 (21%)
		RGS_DHEX	113..214	CDD:375589	17/101 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..257		4/43 (9%)
		GGL	256..316	CDD:128520	14/77 (18%)
		RGS_RGS7	326..446	CDD:188692	43/122 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810