DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loco and Rgs14

DIOPT Version :9

Sequence 1:	NP_732773.1	Gene:	loco / 42672	FlyBaseID:	FBgn0020278	Length:	1541	Species:	Drosophila melanogaster
Sequence 2:	NP_001347643.1	Gene:	Rgs14 / 51791	MGIID:	1859709	Length:	551	Species:	Mus musculus

Alignment Length:	556	Identity:	179/556 - (32%)
Similarity:	270/556 - (48%)	Gaps:	80/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   806 TASVAAEGAAQD-----HGCPS--------------SWAGSFERMLQDAAGMQTFSEFLKKEFSA 851
            ||...|:|..:.     |..||              |||.||||:|||..|:..|:|||||||||
Mouse    27 TAGSQAQGEGRGSSLSIHSLPSGPSSPFSTEEQPVASWAQSFERLLQDPRGLAYFTEFLKKEFSA 91

  Fly   852 ENIYFWTACERYRLL-ESEADRVAQ-AREIFAKHLANNSSDPVNVDSQARSLTEEKLADAAPDIF 914
            ||:.||.||||::.: .|:..::|| |..|:.:.|::.:..|||:|.|| .|:||.||...||:|
Mouse    92 ENVTFWKACERFQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNIDRQA-WLSEEVLAQPRPDMF 155

  Fly   915 APAQKQIFSLMKFDSYQRFIRSDLYKSCVEAEQKNQPLPYSGLDLDELLKTNFHLGA------FS 973
            ...|.|||:|||||||.||::|.||:.|:.||.:.:||...|         :.|||:      ..
Mouse   156 RAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLREPG---------SSHLGSPDTARKKP 211

  Fly   974 KLKKSAS---NAEDRRRKSLL--PWHRKTRSKSRDRTEIMADMQHALMPAPPVPQNAPLTSASLK 1033
            |||...|   ..|:..:..|.  |..|..| ||..|......|..||...   .|.:..:||||.
Mouse   212 KLKPGKSLPLGVEELGQLPLAEGPCGRPLR-KSFRREMTGGAMNSALRRE---SQGSLNSSASLD 272

  Fly  1034 L--VCGQNSLSDLHSSRSSLSSFDAGTATGGQGASTESVYSLCRVILTDGATTIVQTRPGETVGE 1096
            |  :...:|.|:.|  |.||.|        |:..|.......|.|.|.||..::...|||.|:.:
Mouse   273 LGFLAFVSSKSESH--RKSLGS--------GESESESRPGKYCCVYLPDGTASLALARPGLTIRD 327

  Fly  1097 LVERLLEKRNLVYPYYDIVFQGS-TKSIDVQQPSQILAGKEVVIERRVAFKLDLPD-PKVISVKS 1159
            ::..:.|||.|..|...:...|: .|::.:.|...:||.:||.:|.|:.|:|:|.. .:|:.:.:
Mouse   328 MLAGICEKRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISA 392

  Fly  1160 KPKKQLHEVIRPILSKYNYKMEQVQVIMRDTQVPIDLNQPVTMADGQRLRIVMVNSDFQVGGGSS 1224
            ||.|:|.|.::|||:|:...::||.:.....:.|:||..||:....|.| ::....|.::....|
Mouse   393 KPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQPMDLENPVSSVASQTL-VLDTPPDAKMSEARS 456

  Fly  1225 MPPKQSKPMKPLPQ---GHLDELTNKVFNELLASKADAAASEKSRPVDLCSMK-------SNEAP 1279
            :.|.:|:...|..|   .||...::.:..|      ||::|..:|  ..|.::       :....
Mouse   457 ISPCRSQGCLPRTQTKDSHLPPSSSSLLVE------DASSSTGNR--QTCDIEGALPGGAAESGA 513

  Fly  1280 SETSSLFERMRRQQRDG-GNIPASKLPKLKKKSTSS 1314
            .:.....||...|:..| ..|.|:..||.:....|:
Mouse   514 EQRGPRSERTSSQRGPGPSRISAASFPKTRLSGGST 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loco	NP_732773.1	PDZ_signaling	69..145	CDD:238492
		PTB_RGS12	251..391	CDD:269984
		RGS_R12-like	828..941	CDD:188661	61/114 (54%)
		RGS12_RBD	1073..1145	CDD:176412	23/72 (32%)
		RBD	1144..1213	CDD:128731	22/69 (32%)
Rgs14	NP_001347643.1	RGS_RGS14	58..186	CDD:188697	66/128 (52%)
		RBD1_RGS14	303..373	CDD:340657	21/69 (30%)
		RBD2_RGS14	374..446	CDD:340659	23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5880
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144440at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43409
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880